Experimental And Clinical Toxicokinetics
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Experimental And Clinical Toxicokinetics
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Author : Avraham Yacobi
language : en
Publisher:
Release Date : 1984
Experimental And Clinical Toxicokinetics written by Avraham Yacobi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.
Toxicokinetics And Risk Assessment
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Author : John C. Lipscomb
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Toxicokinetics And Risk Assessment written by John C. Lipscomb and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human healt
Toxicokinetics And New Drug Development
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Author : Avraham Yacobi
language : en
Publisher: Pergamon
Release Date : 1989
Toxicokinetics And New Drug Development written by Avraham Yacobi and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Toxicology Of Metals
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Author :
language : en
Publisher:
Release Date : 1987
Toxicology Of Metals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.
Experimental And Clinical Aspects Of Drug Toxicity
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Author : Gerhard Zbinden
language : en
Publisher:
Release Date : 1963
Experimental And Clinical Aspects Of Drug Toxicity written by Gerhard Zbinden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with categories.
Strategies To Protect The Health Of Deployed U S Forces
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-03-17
Strategies To Protect The Health Of Deployed U S Forces written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-17 with Medical categories.
Risk management is especially important for military forces deployed in hostile and/or chemically contaminated environments, and on-line or rapid turn-around capabilities for assessing exposures can create viable options for preventing or minimizing incapaciting exposures or latent disease or disability in the years after the deployment. With military support for the development, testing, and validation of state-of-the-art personal and area sensors, telecommunications, and data management resources, the DOD can enhance its capabilities for meeting its novel and challenging tasks and create technologies that will find widespread civilian uses. Strategies to Protect the Health of Deployed U.S. Forces assesses currently available options and technologies for productive pre-deployment environmental surveillance, exposure surveillance during deployments, and retrospective exposure surveillance post-deployment. This report also considers some opportunities for technological and operational advancements in technology for more effective exposure surveillance and effects management options for force deployments in future years.
Drug Discovery And Evaluation Methods In Clinical Pharmacology
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Author : H.Gerhard Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-15
Drug Discovery And Evaluation Methods In Clinical Pharmacology written by H.Gerhard Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-15 with Medical categories.
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Regulatory Toxicology
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Author : Franz-Xaver Reichl
language : en
Publisher: Springer
Release Date : 2014-03-27
Regulatory Toxicology written by Franz-Xaver Reichl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-27 with Medical categories.
This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.
Biomarkers In Toxicology
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Author : Ramesh C Gupta
language : en
Publisher: Academic Press
Release Date : 2014-01-25
Biomarkers In Toxicology written by Ramesh C Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-25 with Technology & Engineering categories.
Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more
Pharmacokinetics And Toxicokinetics
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Author : Mehdi Boroujerdi
language : en
Publisher: CRC Press
Release Date : 2015-02-24
Pharmacokinetics And Toxicokinetics written by Mehdi Boroujerdi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-24 with Mathematics categories.
Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different appr