Exploiting Multivalency In Protein Carbohydrate Interactions
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Exploiting Multivalency In Protein Carbohydrate Interactions
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Author : Patricia Anne Mowery
language : en
Publisher:
Release Date : 2003
Exploiting Multivalency In Protein Carbohydrate Interactions written by Patricia Anne Mowery and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Multivalency Effects In Protein Carbohydrate Interactions
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Author : Jayme Blair Corbell
language : en
Publisher:
Release Date : 2002
Multivalency Effects In Protein Carbohydrate Interactions written by Jayme Blair Corbell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Biosynthesis categories.
Towards The Molecular Basis Of Affinity In Monovalent And Multivalent Protein Carbohydrate Interactions
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Author : Andrea Elizabeth Luteran
language : en
Publisher:
Release Date : 2007
Towards The Molecular Basis Of Affinity In Monovalent And Multivalent Protein Carbohydrate Interactions written by Andrea Elizabeth Luteran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Carbohydrates categories.
Multivalent interactions are most frequently considered from an entropic perspective, attributed to entropically-assisted chelate type bonding. In order to obtain true thermodynamic parameters describing multivalency, a system must be in equilibrium and not kinetically-trapped in a non-equilibrium state. Divalent barium binding to EDTA and the conceptual fragments of EDTA serve as a powerful model of multivalency. Analysis of calorimetric data after the Jencks formalism reveals a favorable increment in interaction enthalpy of the binding for each acetate epitope; this behavior is attributed to relief of unfavorable coulombic repulsion in the unbound state. Comparison of the binding of chelates to Ca(II) and Ba(II) shows similar trends, although, the pentavalent DTPA lacks an increase in interaction energy when bound to Ca(II) due to an octahedral coordination geometry. Additionally, EDTA binds to Ba(II) with a lower affinity than Ca(II). This diminished affinity arises because the main structural elements in the Ba(II)-EDTA complex deviate significantly from the optimized geometries seen in the Ca(II)-EDTA complex.
Glycoscience
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Author : Bertram O. Fraser-Reid
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-14
Glycoscience written by Bertram O. Fraser-Reid and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-14 with Science categories.
As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.
Multivalency
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Author : Jurriaan Huskens
language : en
Publisher: John Wiley & Sons
Release Date : 2018-02-05
Multivalency written by Jurriaan Huskens and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-05 with Science categories.
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.
Carbohydrate Recognition
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Author : Binghe Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-09
Carbohydrate Recognition written by Binghe Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-09 with Medical categories.
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Fragment Based Approaches In Drug Discovery
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Author : Wolfgang Jahnke
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
Fragment Based Approaches In Drug Discovery written by Wolfgang Jahnke and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Synthesis And Biological Applications Of Glycoconjugates
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Author : Olivier Renaudet
language : en
Publisher: Bentham Science Publishers
Release Date : 2011
Synthesis And Biological Applications Of Glycoconjugates written by Olivier Renaudet and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The interactions between carbohydrates and proteins have been extensively explored in a wide range of physiological and pathological processes over several decades. The recent emergence of glycomics has strengthened this interest and notably contributed t
Carbohydrate Chemistry Chemical And Biological Approaches Volume 44
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Author : Amelia Pilar Rauter
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-10-06
Carbohydrate Chemistry Chemical And Biological Approaches Volume 44 written by Amelia Pilar Rauter and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-06 with Science categories.
Carbohydrate Chemistry is an invaluable volume demonstrating the interdisciplinary nature of modern carbohydrate research and containing analysed, evaluated and distilled information on the latest research in the area.
Essentials Of Glycobiology
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Author : Ajit Varki
language : en
Publisher: CSHL Press
Release Date : 1999
Essentials Of Glycobiology written by Ajit Varki and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
