Exploring New Findings On Amyloidosis
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Exploring New Findings On Amyloidosis
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Author : Ana Maria Fernandez-Escamilla
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-24
Exploring New Findings On Amyloidosis written by Ana Maria Fernandez-Escamilla and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-24 with Medical categories.
Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.
The Importance Of Macrophages Lipid Membranes And Seeding In Experimental Aa Amyloidosis
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Author : Aida Vahdat Shariatpanahi
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-08-15
The Importance Of Macrophages Lipid Membranes And Seeding In Experimental Aa Amyloidosis written by Aida Vahdat Shariatpanahi and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-15 with categories.
Amyloidosis is a group of protein misfolding diseases caused by tissue deposition of fibrillary protein aggregates termed amyloid. Amyloid A (AA) amyloidosis is a systemic form of amyloidosis that occurs as a complication of chronic inflammatory diseases, such as rheumatoid arthritis, familial Mediterranean fever and chronic infections, such as tuberculosis. AA amyloid is derived from the precursor protein serum amyloid A and is deposited in several organs preferably kidneys, liver and spleen. AA amyloidosis can be induced in mice by long standing inflammatory stimulation and concurrent administration of tissue extracts of AA amyloid, referred to as amyloid enhancing factor (AEF), reduces the time for amyloid deposition in the marginal zone of the spleen from 5 weeks to 2 days. The general aim of this thesis was to investigate the mechanisms involved in the development of AA amyloid in the mouse model of AA amyloidosis. Amyloid was induced in inflamed mice by injection of AEF and amyloid toxicity to splenic macrophages was investigated. We found that the marginal zone macrophages were very sensitive to amyloid formation and increasing amyloid load caused progressive depletion of these cells, whereas red pulp macrophages and metallophilic marginal zone macrophages appeared unaffected. To clarify the role of splenic macrophages in amyloidogenesis, macrophages were depleted by clodronate containing liposomes. We displayed that in the absence of splenic macrophages, especially marginal zone macrophages, amyloid formation was delayed implying a crucial role of macrophages in amyloid formation. The effect of lipid membranes on amyloid formation was studied and we showed that liposomes exhibited an amyloidogenic effect in inflamed mice although not as powerful as AEF. Following the fate of the liposomes, we showed that liposomes were rapidly cleared by uptake in the spleen and liver and colocalized with lysosomes. A tentative mechanism might be that accumulation of liposomes in lysosomes interfere with the SAA degradation process facilitating amyloid formation. Finally the conformational properties of two AEF (AEF1 and AEF2) preparations were studied using conformation sensitive luminescent-conjugated oligothiophenes (LCOs). We found that AEF1 and AEF2 displayed significantly different ultrastructure as well as conformation and consequently induced different cytotoxicity in vitro. Inducing amyloid formation in inflamed mice by AEF1 and AEF2 revealed that the polymorph of the amyloid aggregates was replicated in vivo. In summary, the results obtained in this thesis indicate an important role for macrophages for the formation of amyloid. The existence of amyloid strains has long been an in vitro finding, but the finding that AEF ultrastructure drives the morphology of newly formed amyloid in vivo opens up for new studies that can help us to understand the formation of homologous and heterologous fibrils. Thus, the fundamental mechanisms of various amyloid diseases are similar and the results presented in the thesis can increase the understanding of other amyloid diseases.
Amyloidosis New Insights For The Healthcare Professional 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Amyloidosis New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Amyloidosis: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Amyloidosis in a concise format. The editors have built Amyloidosis: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Amyloidosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Amyloidosis: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Pathologic Findings Of Amyloidosis
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Author : Jae Y. Ro
language : en
Publisher:
Release Date : 2022
Pathologic Findings Of Amyloidosis written by Jae Y. Ro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Electronic books categories.
Amyloids are aggregations of misfolded protein, which creates fibrillary structures. Unlike normally folded proteins, misfolded fibrils are insoluble and deposited extracellularly or intracellularly. The pathologic mechanism is still unclear, but resultant toxic oligomers within the tissue are known to damage the tissue via aberrant protein interactions. This condition has been known as amyloidosis. Different kinds of amyloid protein may cause similar or different clinical signs and symptoms, largely depending on the target organ it is deposited. However, because treatments and prognoses of each type are different drastically, it is critical to distinguish them and determine the specific type of amyloidosis. The confirmation and typing of amyloid heavily depend on pathologic examination of tissue. The gold standard method for the former is a Congo red staining and birefringence under polarized microscopy. The conventional way for the latter is immunohistochemistry (IHC), where most of the amyloid types can be classified. However, electron microscopy, mass spectrometry, or other molecular methods are required for typing some amyloids that are difficult to identify through IHC. In this chapter, we will describe basic concepts of amyloidosis and pathologic findings of amyloid deposition, including atypical structural deposition. Furthermore, we will review methodologies for amyloid typing briefly.
Proceedings And Predictions In Cardiac Amyloidosis Unsolved Mysteries And Challenges For The Future
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Author : Aldostefano Porcari
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-02
Proceedings And Predictions In Cardiac Amyloidosis Unsolved Mysteries And Challenges For The Future written by Aldostefano Porcari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Medical categories.
Periodontitis And Systemic Diseases
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Author : Josefine Hirschfeld
language : en
Publisher: Quintessenz Verlag
Release Date : 2021-04-19
Periodontitis And Systemic Diseases written by Josefine Hirschfeld and has been published by Quintessenz Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-19 with Medical categories.
The association between periodontitis and systemic diseases has become a hot topic in recent years. This comprehensive book reviews the clinical evidence and biological plausibility of the many systemic diseases that have been linked to periodontitis. Edited by Dr Josefine Hirschfeld and Prof Iain L.C. Chapple, experts in each field discuss the mechanisms at work, citing the available key literature and clearly summarising current knowledge and understanding of the associations between periodontitis and diabetes mellitus, cardiovascular diseases, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, respiratory diseases, pregnancy and fertility, malignancy, neurodegenerative diseases, stress and depression, and autoimmunity. Each chapter critically appraises the existing evidence, providing comprehensive, contemporary and well-considered insights into the clinical evidence and biological plausibility of each condition, as well as the limitations of existing studies and how these can be overcome in the future. Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility is an indispensable reference for both clinicians and researchers.
Mitochondria In Health And Disease
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Author : Ray Griffiths
language : en
Publisher: Singing Dragon
Release Date : 2018-04-19
Mitochondria In Health And Disease written by Ray Griffiths and has been published by Singing Dragon this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-19 with Health & Fitness categories.
What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions? This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.
Glioblastoma Resistance To Chemotherapy Molecular Mechanisms And Innovative Reversal Strategies
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Author : Ramasamy Paulmurugan
language : en
Publisher: Academic Press
Release Date : 2021-06-25
Glioblastoma Resistance To Chemotherapy Molecular Mechanisms And Innovative Reversal Strategies written by Ramasamy Paulmurugan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-25 with Science categories.
Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance
Experimental Models For Renal Diseases
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Author : G.A. Herrera
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2011-01-14
Experimental Models For Renal Diseases written by G.A. Herrera and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-14 with Medical categories.
Our understanding of the pathogenesis of renal diseases and the ability to accurately classify and diagnose them has improved considerably over the last two decades. Until now, however, this information has not been available in a single, up-to-date and succinct yet comprehensive source. The publication at hand aims at filling this gap, condensing a vast amount of information into easily accessible chapters.After a discussion of basic concepts and principles of renal tissue reactions to injurious agents using a specific cell/compartment approach, a multitude of disorders are looked at, including renal interstitial fibrosis, glomerulosclerosis, various forms of glomerulonephritis and nephropathy, amyloidosis and renal Fanconi syndrome. Some of the chapters address controversial subjects, reporting the current situation and showing areas of future potential research interest. At the end of many of the contributions, a summary is provided, often in the form of a chart to facilitate the understanding of the information and to make it most useful for didactic purposes.This book is intended for students of various disciplines, as well as clinicians and investigators and all those trying to correlate basic research information with clinical issues.
Amyloidosis
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Author : Morie A. Gertz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-14
Amyloidosis written by Morie A. Gertz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-14 with Medical categories.
An up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this complex disease.