For A Interior A Nica Fonte De Realiza O Poss Vel
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Conjugate Divergent Margins
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Author : Webster Mohriak
language : en
Publisher: Geological Society of London
Release Date : 2013
Conjugate Divergent Margins written by Webster Mohriak and has been published by Geological Society of London this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Nature categories.
The main focus of the book is the geological and geophysical interpretation of sedimentary basins along the South, Central and North Atlantic conjugate margins, but concepts derived from physical models, outcrop analogues and present-day margins are also discussed in some chapters. There is an encompassing description of several conjugate margins worldwide, based on recent geophysical and geological datasets. An overview of important aspects related to the geodynamic development and petroleum geology of Atlantic-type sedimentary basins is also included. Several chapters analyse genetic mechanisms and break-up processes associated with rift-phase structures and salt tectonics, providing a full description of conjugate margin basins based on deep seismic profiles and potential field methods.--
Course In General Linguistics
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Author : Ferdinand de Saussure
language : en
Publisher: Open Court Publishing
Release Date : 1986
Course In General Linguistics written by Ferdinand de Saussure and has been published by Open Court Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Language Arts & Disciplines categories.
Reconstructed from lecture notes of his students, these are the best records of the theories of Ferdinand De Saussure, the Swiss linguist whose theories of language are acknowledged as a primary source of the twentieth century movement known as Structuralism.
Sediment Toxicity Assessment
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Author : G.Allen Burton
language : en
Publisher: CRC Press
Release Date : 2018-05-04
Sediment Toxicity Assessment written by G.Allen Burton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.
Sediment Toxicity Assessment provides the latest information regarding how to evaluate sediment contamination and its effects on aquatic ecosystems. It presents an integrated ecosystem approach by detailing effective assessment methods, considerations, and effects to each major component of marine and freshwater systems, including the benthos, plankton, and fish communities. The approaches emphasize defining habitat conditions (physical and chemical), toxicant bioavailability, factors influencing toxicity (lab and field), biomarkers, acute and chronic toxicity, study design, collection methods, and EPA management strategies. The book also explains how to integrate the assessments. Sediment Toxicity Assessment will be useful to to all environmental managers, environmental scientists, ecotoxicologists, environmental regulators, aquatic ecologists, environmental contractors and consultants, instructors, students, conservation commissions, and environmental activist organizations.
Book Of Love And Pain The
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Author : Juan-David Nasio
language : en
Publisher: SUNY Press
Release Date : 2012-02-01
Book Of Love And Pain The written by Juan-David Nasio and has been published by SUNY Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-01 with Psychology categories.
Addresses the limits in treating pain psychoanalytically, and offers a phenomenological description of psychic pain, particularly the pain of a lost loved one.
Roots Of Brazil
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Author : Sérgio Buarque de Holanda
language : en
Publisher: University of Notre Dame Pess
Release Date : 2012-10-15
Roots Of Brazil written by Sérgio Buarque de Holanda and has been published by University of Notre Dame Pess this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-15 with History categories.
Sérgio Buarque de Holanda's Roots of Brazil is one of the iconic books on Brazilian history, society, and culture. Originally published in 1936, it appears here for the first time in an English language translation with a foreword, "Why Read Roots of Brazil Today?" by Pedro Meira Monteiro, one of the world's leading experts on Buarque de Holanda. Roots of Brazil focuses on the multiple cultural influences that forged twentieth-century Brazil, especially those of the Portuguese, the Spanish, other European colonists, Native Americans, and Africans. Buarque de Holanda argues that all of these originary influences were transformed into a unique Brazilian culture and society—a "transition zone." The book presents an understanding of why and how European culture flourished in a large, tropical environment that was totally foreign to its traditions, and the manner and consequences of this development. Buarque de Holanda uses Max Weber’s typological criteria to establish pairs of "ideal types" as a means of stressing particular characteristics of Brazilians, while also trying to understand and explain the local historical process. Along with other early twentieth-century works such as The Masters and the Slaves by Gilberto Freyre and The Colonial Background of Modern Brazil by Caio Prado Júnior, Roots of Brazil set the parameters of Brazilian historiography for a generation and continues to offer keys to understanding the complex history of Brazil. Roots of Brazil has been published in Italian, Spanish, Japanese, Chinese, German, and French. This long-awaited English translation will interest students and scholars of Portuguese, Brazilian, and Latin American history, culture, literature, and postcolonial studies.
Nature
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Author : Maurice Merleau-Ponty
language : en
Publisher: Northwestern University Press
Release Date : 2003
Nature written by Maurice Merleau-Ponty and has been published by Northwestern University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Philosophy categories.
Collected in this text are the written notes of courses on the concept of nature give by Merleau-Ponty at the College de France in the 1950s. The ideas that animated the philosopher's lectures emerge in an early, fluid form in the process of being elaborated, negotiated, critiqued and reconsidered.
The Condition Of The Working Class In England In 1844
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Author : Frederick Engels
language : en
Publisher: BookRix
Release Date : 2014-02-12
The Condition Of The Working Class In England In 1844 written by Frederick Engels and has been published by BookRix this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-12 with History categories.
The Condition of the Working Class in England is one of the best-known works of Friedrich Engels. Originally written in German as Die Lage der arbeitenden Klasse in England, it is a study of the working class in Victorian England. It was also Engels' first book, written during his stay in Manchester from 1842 to 1844. Manchester was then at the very heart of the Industrial Revolution, and Engels compiled his study from his own observations and detailed contemporary reports. Engels argues that the Industrial Revolution made workers worse off. He shows, for example, that in large industrial cities mortality from disease, as well as death-rates for workers were higher than in the countryside. In cities like Manchester and Liverpool mortality from smallpox, measles, scarlet fever and whooping cough was four times as high as in the surrounding countryside, and mortality from convulsions was ten times as high as in the countryside. The overall death-rate in Manchester and Liverpool was significantly higher than the national average (one in 32.72 and one in 31.90 and even one in 29.90, compared with one in 45 or one in 46). An interesting example shows the increase in the overall death-rates in the industrial town of Carlisle where before the introduction of mills (1779–1787), 4,408 out of 10,000 children died before reaching the age of five, and after their introduction the figure rose to 4,738. Before the introduction of mills, 1,006 out of 10,000 adults died before reaching 39 years old, and after their introduction the death rate rose to 1,261 out of 10,000.
Safe Piped Water
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Author : Ainsworth R.
language : en
Publisher: World Health Organization
Release Date : 2004-09-21
Safe Piped Water written by Ainsworth R. and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-21 with Business & Economics categories.
This publication addresses the factors affecting the presence and growth of micro-organisms in piped networks as well as the practices of water supply organisations that can directly or indirectly influence them. The book shows that there are often public health reasons for adopting a more proactive approach to many of the traditional practices used in designing, operating and maintaining distribution networks, and to modifying the composition of the water that is fed into those networks.
Curtain Call
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Author : Lisa Timpf
language : en
Publisher: JMS Books LLC
Release Date : 2021-04-10
Curtain Call written by Lisa Timpf and has been published by JMS Books LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-10 with Fiction categories.
From the first time she picked up a softball bat, Kayla has loved team games of any stripe. Now in her mid-forties, though, she is starting to come to the bitter realization that like all good things, her involvement in team sports must come to an end one day, whether she’s ready or not. When her broomball teammates start making noises about this being their final season together, Kayla sets her sights on capturing the league championship. What better way to remind them of how much fun it can be to win? The prospect of snagging the league title seems brighter with the addition of a new player, Val, who Kayla would like to get to know better. That is, if her meddlesome ex Abby will stay out of the picture long enough. Will winning the championship be enough to bring Kayla’s teammates back for one more season? If not, what can she do about it?