Galectins
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Galectins
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Author : Anatole A. Klyosov
language : en
Publisher: John Wiley & Sons
Release Date : 2008-10-17
Galectins written by Anatole A. Klyosov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-17 with Science categories.
The comprehensive guide to the current understanding of galectins and their promising potential in drug design This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes: * An overview of early galectin research * An explanation of the nature of galectins * A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell * An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity * A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance * An introduction to new approaches to designing galectin inhibitors This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.
Galectins In Cancer And Translational Medicine
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Author : Armando Bartolazzi
language : en
Publisher: MDPI
Release Date : 2018-11-29
Galectins In Cancer And Translational Medicine written by Armando Bartolazzi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-29 with Electronic books categories.
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin-glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
Galectins
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Author : Sean R. Stowell
language : en
Publisher: Humana Press
Release Date : 2014-09-25
Galectins written by Sean R. Stowell and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-25 with Science categories.
Galectins: Methods and Protocols is the first book solely dedicated to methodological approaches designed to study galectin function. The galectin family represents one of the most pleiotropic families, with individual members having been implicated in various aspects of nearly every biological process described, from RNA splicing to complex regulatory circuits that orchestrate adaptive immunity. Given the diverse roles of galectins in a variety of biological systems, studying these glycan binding proteins often requires the assimilation of diverse technical skills to fully appreciate their biological function. Their nearly ubiquitous expression and ability to bind highly modifiable carbohydrate ligands, in addition to a variety of other regulatory proteins, allows these glycan binding proteins (GBPs) to possess the capacity to regulate a wide variety of biological processes. Individual chapters are dedicated to examining salient features of galectin functions. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Galectins: Methods and Protocols seeks to serve both professionals and novices with a useful framework when examining galectin function for many years to come.
Galectins Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Galectins Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Galectins—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Galectins in a concise format. The editors have built Galectins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Galectins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Galectins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Galectins And Disease Implications For Targeted Therapeutics
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Author : Anatole Klyosov
language : en
Publisher: OUP USA
Release Date : 2013-07-04
Galectins And Disease Implications For Targeted Therapeutics written by Anatole Klyosov and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-04 with Science categories.
Provides discussion of the latest work in Galectins, stemming from the Symposium 'Galectin Functions and Therapeutics.'
Galectins In Cancer And Translational Medicine
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Author : Armando Bartolazzi
language : en
Publisher:
Release Date : 2018
Galectins In Cancer And Translational Medicine written by Armando Bartolazzi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin-glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
Galectins And Disease Implications For Targeted Therapeutics
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Author : Shawana Heaney
language : en
Publisher: States Academic Press
Release Date : 2023-09-26
Galectins And Disease Implications For Targeted Therapeutics written by Shawana Heaney and has been published by States Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Galectins are a class of carbohydrate-binding proteins characterized by the presence of b-galactoside-binding sites. They are also referred to as S-type lectins. These molecules are involved in many physiological and biological functions of the body such as inflammation, immune responses, cell migration, autophagy, RNA splicing, gene transcription, apoptosis, signaling and differentiation. Galectins have also been linked to diseases such as fibrosis, cancer and heart disease. Galectin-3 plays a considerable role in cancer progression and the processes associated with tumorigenesis such as transformation to a malignant form, metastasis, and increased invasive properties of tumor cells. It has also been researched as a potential biomarker of rheumatic diseases. Galectins have a unique mechanism to intracellularly as well as extracellularly regulate cell death. This book is compiled in such a manner, that it will provide in-depth knowledge about the role of galectins in disease. It includes contributions of experts and scientists, which will provide innovative insights into this area of study. The extensive content of this book provides the readers with a thorough understanding of the subject.
Cell Biology Of Galectins
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Author : Alexander Timoshenko
language : en
Publisher:
Release Date : 2022
Cell Biology Of Galectins written by Alexander Timoshenko and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Galectins are a family of soluble beta-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions outside and inside the cell. There are sixteen recognized mammalian galectin genes, and their expression profiles are very different between cell types, tissues, and species. This Special Issue covers recent progress in the field of the cell biology of galectins, relevant concepts of galectin regulatory mechanisms, and biomedical aspects of these unique multifunctional proteins.
Nuclear Galectins And Their Role In Pre Mrna Splicing
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Author : Weizhong Wang
language : en
Publisher:
Release Date : 2006
Nuclear Galectins And Their Role In Pre Mrna Splicing written by Weizhong Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Messenger RNA. categories.
Small Molecule Galectin Ligands
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Author : Sjors van Klaveren
language : en
Publisher:
Release Date : 2024
Small Molecule Galectin Ligands written by Sjors van Klaveren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with categories.
In the body, all cell surfaces are covered with glycans, and many regulatory components have carbohydrates attached to them, which can aid in their function. Galectins are a family of proteins which can bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellular processes. The members of the galectin family are structurally similar and can be involved in the same processes. Inside the cell, galectins have been observed assisting in the detection of exposed glycans on damaged intracellular vesicles, initiating autophagy which helps to clear out damaged cells and bacterial infections. Some galectins have a role in promoting angiogenesis and lymphangiogenesis. This is associated with the repair of damaged tissue and with the growth of tumours. Studies have also implicated galectins in autoimmune disorders and neurodegenerative diseases. The research in this doctoral dissertation focused on the discovery and development of selective, high-affinity ligands for several galectins, with a special focus on galectin-8. Several structurally diverse libraries of compounds were synthesised as part of ligand-based and structure-based approaches. From these libraries, several novel hits for galectin-1, -3, and -8N were discovered and structure-activity relationships identified. These hits were optimised to produce galectin ligands with sub-micromolar affinities and analogues with almost complete selectivity for galectin-8N over all other tested galectins. Such highly selective compounds may help to study the biological roles of galectins and the pathologies in which they are involved. This may also, in turn, lead to galectin-8N inhibitors with a pharmaceutical potential.