Gene Therapy Of Cochlear Deafness
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Gene Therapy Of Cochlear Deafness
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Author : Allen F. Ryan
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2009-01-01
Gene Therapy Of Cochlear Deafness written by Allen F. Ryan and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Medical categories.
This volume reviews current concepts and recent research findings of the application of gene therapy to the inner ear. Various forms of gene therapy, disorders that are potential targets for gene therapy, techniques for gene delivery, and mechanisms of gene targeting, and also obstacles that have yet to be overcome are discussed.
Outstanding Features Of Recent Advances In Cochlear Gene Therapy
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Author : DR. HAKIM. SABOOWALA
language : en
Publisher: Dr.Hakim Saboowala
Release Date : 2019-11-12
Outstanding Features Of Recent Advances In Cochlear Gene Therapy written by DR. HAKIM. SABOOWALA and has been published by Dr.Hakim Saboowala this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-12 with Medical categories.
Cochlear gene therapy has undergone tremendous advances over the past decade. Beginning with some groundbreaking work in 2005 documenting hair cell regeneration using virally mediated delivery of the mouse atonal 1 gene, gene therapy is now being explored as a possible treatment for a variety of causes of hearing loss. Recent advances in cochlear gene therapy include improved methods of gene delivery with a better delineation of viral vectors that are suitable for this purpose, additional improvements in hair cell regeneration, and directed research towards: · Autoimmune hearing loss, · Ototoxicity, · Spiral ganglion survival, and · Genetic forms of hearing loss. If successful, cochlear gene therapy will dramatically alter our ability to treat a variety of forms of acquired and genetic hearing loss. An attempt has been made in this Booklet to highlight recent advances in cochlear gene therapy over the past several years. ….. Dr. H.K.Saboowala.M.B.(Bom) M.R.S.H.(London)
Genetics Of Deafness
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Author : B. Vona
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2016-04-21
Genetics Of Deafness written by B. Vona and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Genetics of Deafness offers a journey through areas crucial for understanding the causes and effects of hearing loss. It covers such topics as the latest approaches in diagnostics and deafness research and the current status and future promise of gene therapy for hearing restoration. The book begins by bringing attention to how hearing loss affects the individual and society. Methods of hearing loss detection and management throughout the lifespan are highlighted as is a particularly new development in newborn hearing screening. The challenges of hearing loss, an extremely heterogeneous impairment, are addressed. Additional topics include current research interests, ranging from novel gene identification to their functional validation in the mouse and zebrafish. The book ends with a chapter on the state of the art of gene therapy—an area that is certain to gain increasing attention as molecular mechanisms of deafness are better understood. Genetics of Deafness, written by leading authors in the field, is a must read for clinicians, researchers, and students. It provides much needed insight into the diagnosis and research of hereditary hearing loss.
Gene Therapy For Hearing Loss From Mechanism To Clinic Volume Ii
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Author : Zuhong He
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-23
Gene Therapy For Hearing Loss From Mechanism To Clinic Volume Ii written by Zuhong He and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Science categories.
Gene Therapy For Hearing Loss From Mechanism To Clinic
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Author : Zuhong He
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-02
Gene Therapy For Hearing Loss From Mechanism To Clinic written by Zuhong He and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Science categories.
Genes Hearing And Deafness
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Author : Alessandro Martini
language : en
Publisher: CRC Press
Release Date : 2007-06-13
Genes Hearing And Deafness written by Alessandro Martini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-13 with Medical categories.
The field of generic hearing impairment is one where rapid advances are taking place, and it can often be difficult for Audiologists to keep track of the broader picture. In this important new text the authors take a synoptic approach and summarize the causes and basis of hearing impairments, the impact on the individual and the therapies available
Molecular Mechanisms Of Sensorineural Hearing Loss And Development Of Inner Ear Therapeutics
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Author : Srdjan M Vlajkovic
language : en
Publisher:
Release Date : 2021
Molecular Mechanisms Of Sensorineural Hearing Loss And Development Of Inner Ear Therapeutics written by Srdjan M Vlajkovic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of age-related and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs.
Gene Therapy And Therapeutic Interventions In The Auditory System
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Author : Gary D. Housley
language : en
Publisher:
Release Date : 2002
Gene Therapy And Therapeutic Interventions In The Auditory System written by Gary D. Housley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Audiology categories.
This special issue represents the third of three issues containing papers arising from the 'Auditory Function and Dysfunction: Molecular and Physiological Mechanisms' symposium held in Auckland, New Zealand in August 2001. It reflects on the exciting advances that are being made in our understanding of the molecular basis of cochlear development, neurodegeneration and the attempts to provide otoprotective strategies. One group of papers deals with some of the genetic aspects of cochlear development and hearing loss. In a second group the advances being made in strategies to protect the inner ear from stress and ototoxic drugs that may ultimately form the basis of treatments for inner ear disorders are being discussed. The last group of papers considers the delivery of compounds to the inner ear for its genetic or pharmacological manipulation. This and the other two issues stemming from the symposium will be valuable contributions to the communication between the wide-ranging disciplines within the hearing sciences and the clinic.
Regenerative Medicine For The Inner Ear
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Author : Juichi Ito
language : en
Publisher: Springer
Release Date : 2014-08-05
Regenerative Medicine For The Inner Ear written by Juichi Ito and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-05 with Medical categories.
The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
Hearing Loss Mechanisms Prevention And Cure
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Author : Huawei Li
language : en
Publisher: Springer
Release Date : 2019-03-26
Hearing Loss Mechanisms Prevention And Cure written by Huawei Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-26 with Medical categories.
This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients’ ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialists and researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.