Genetic Analysis Of Neurite Branching Development In Caenorhabditis Elegans
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Genetic Analysis Of Axon Guidance And Branching In C Elegans
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Author : Joe C. Hao
language : en
Publisher:
Release Date : 2003
Genetic Analysis Of Axon Guidance And Branching In C Elegans written by Joe C. Hao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Png 1 A Peptide
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Author : Nasrin Habibi-Babadi
language : en
Publisher:
Release Date : 2014
Png 1 A Peptide written by Nasrin Habibi-Babadi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Genetic Analysis Of The Neuronal Integrated Stress Response In Developmental Plasticity And Organismal Physiology Of C Elegans
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Author : Warakorn Kulalert
language : en
Publisher:
Release Date : 2017
Genetic Analysis Of The Neuronal Integrated Stress Response In Developmental Plasticity And Organismal Physiology Of C Elegans written by Warakorn Kulalert and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
The genetic study of the C. elegans dauer developmental decision has served as an experimental paradigm for understanding how environmental cues influence organismal physiology through evolutionarily conserved neuroendocrine signaling mechanisms. My genetic characterization of the previously isolated daf-28(sa191) mutant that enters dauer constitutively has revealed cell-nonautonomous roles of conserved stress signaling pathways-the Unfolded Protein Response (UPR) and translational control mediated by eIF2[alpha] phosphorylation. While the cell-autonomous functions of these stress-responsive mechanisms in maintaining cellular homeostasis have been examined, their organismal effects on remodeling development and stress responses remain largely unexplored. Chapter II will highlight the hypotheses and approaches that led to identification of the PEK-1/PERK branch of the UPR, functioning in a pair of chemosensory neurons, as a novel regulator of the dauer developmental decision. Chapter III will examine the systemic effects of eIF2[alpha] phosphorylation, downstream of PERK/PEK-1 activation, in the sensory nervous system on larval development and stress responses. Specifically, the identification of the C. elegans translational regulatory factors that function as molecular determinants of cellular and systemic sensitivity to eIF2[alpha] phosphorylation will be described. Subsections of Chapter III and IV will also highlight genes whose functions can modify the organismal effects of the UPR and eIF2[alpha] phosphorylation: these genes are involved in modulation of ER proteostasis or function in the dauer neuroendocrine pathways that interact with the UPR or eIF2[alpha] phosphorylation. Finally, we proceed to show that alterations in the neuronal eIF2[alpha] phosphorylation status may modulate sensory processing to influence diverse physiological outputs, mimicking the effects of starvation or unfavorable microbial environment. Collectively, results from my study indicate that modulation of the UPR and eIF2[alpha]-mediated translational control in the sensory nervous system confers substantial cell-nonautonomous effects on animal physiology. These findings underscore how molecular events underlying cellular homeostasis, which can be perturbed by fluctuating environmental and developmental conditions, may be co-opted to systemically reprogram organismal stress responses in C. elegans.
Ageing Lessons From C Elegans
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Author : Anders Olsen
language : en
Publisher: Springer
Release Date : 2016-12-06
Ageing Lessons From C Elegans written by Anders Olsen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-06 with Medical categories.
This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.
Genomic Regulatory Systems
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Author : Eric H. Davidson
language : en
Publisher: Elsevier
Release Date : 2001-01-24
Genomic Regulatory Systems written by Eric H. Davidson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-24 with Science categories.
The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Genetic Analysis Of Axon Outgrowth In Caenorhabditis Elegans
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Author : Nehal Mehta
language : en
Publisher:
Release Date : 2004
Genetic Analysis Of Axon Outgrowth In Caenorhabditis Elegans written by Nehal Mehta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
A Molecular And Genetic Analysis Of The Developing Visual System In Drosophila Melanogaster
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Author : Allen James Ebens (Jr.)
language : en
Publisher:
Release Date : 1995
A Molecular And Genetic Analysis Of The Developing Visual System In Drosophila Melanogaster written by Allen James Ebens (Jr.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Nematode Models Of Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-05-13
Nematode Models Of Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-13 with Science categories.
Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology
Cellular Migration And Formation Of Axons And Dendrites
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Author : Bin Chen
language : en
Publisher: Academic Press
Release Date : 2020-05-29
Cellular Migration And Formation Of Axons And Dendrites written by Bin Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Medical categories.
Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Microtubule Dynamics
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Author : Anne Straube
language : en
Publisher: Humana Press
Release Date : 2017-04-30
Microtubule Dynamics written by Anne Straube and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-30 with Science categories.
Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.