Genetic Approaches To Mental Disorders
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Genetic Approaches To Mental Disorders
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Author : Elliot S. Gershon
language : en
Publisher: American Psychiatric Pub
Release Date : 1994
Genetic Approaches To Mental Disorders written by Elliot S. Gershon and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Since the 1940s, the American Psychopathological Association has been a driving force in psychiatric genetic research. Having studied the Kallmann and Kety Hoch Award papers, many researchers have attempted to advance psychiatric genetic knowledge from epidemiological findings to biological findings. Genetic Approaches to Mental Disorders provides the latest information on the relationship between genetics and mental disorders. Divided into four sections, this book presents analysis of the genetic data, linkage mapping and association, debate over genetic Kraepelinian dichotomy, and mapping and association results in psychiatry.
Genetic Approaches In The Prevention Of Mental Disorders
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Author : Victor Bulyzhenkov
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Genetic Approaches In The Prevention Of Mental Disorders written by Victor Bulyzhenkov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
At least 40 million people in the worId suffer from the most severe forms of mental disorder such as schizophrenia and some 300 million more are affected by less severe but still incapacitating forms of these conditions, including, for example, drug and alcohol dependence and the consequences of brain trauma. The enor mous magnitude of human suffering and the economic losses usually linked of these disorders make them a problem of major public health importance. Recent years have brought with them scientific discoveries which have made it possible to successfully treat most mental disorders and to prevent many others. Some of them, however, cannot be prevented on the basis of today's knowledge, and their treatment remains palliative: further progress in their management awaits an improvement in our understanding of mechanisms by which they come into existence and of factors which influence their course. Recent years have also seen a significant increase in knowledge about genetic factors influencing the occurrence and course of a variety of diseases, for example, cystic fibrosis, Duchenne type muscular dystrophy, thalassemia, and hyperten sion. Some of this knowledge and some of the methods that have been developed to obtain it could have direct relevance to the search for a c1earer comprehension of the pathogenesis of mental disorder.
Genetic Approaches To Mental Disorders In Humans
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Author : Haiyan Xu
language : en
Publisher:
Release Date : 2006
Genetic Approaches To Mental Disorders In Humans written by Haiyan Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Ethical Issues Of Molecular Genetics In Psychiatry
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Author : Radim J. Sram
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Ethical Issues Of Molecular Genetics In Psychiatry written by Radim J. Sram and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Over the past few years, genetics research has been in a phase of remarkably sustained and continuous revolution. The advent of "new genetics" of recombinant DNA has resulted in new discoveries occurring at a breath taking pace, many of which have important clinical implications, for example, in new approaches to the diagnosis and treatment of hemoglobinopathies, cystic fibrosis and some forms of muscular dystrophies. Recent findings of psychiatric relevance have included the localization of the genes for Huntington's chorea and the use of DNA probes in predictive testing. Advances have been achieved in the understanding of the molecular biology of Alzheimer's disease, and at least some familiar forms of the condition appear to be linked to a gene of chromosome 21. Taking into account current achievements in molecular genetics as well as future findings, it can be predicted that the application of new genetic technologies is likely to lead to ethical problems in practical psychiatry. In order to initiate discussions aiming to generate ideas and develop the background for future consensus in the complex area of ethics relating to the application of molecular approaches in the study of psychiatric disorders, the World Health Organization, in collaboration with the IPSEN Foundation, organized in Brno, Czechoslovakia, June 11-12, 1990, an international conference to review knowledge related to molecular genetic studies in psychiatry, with particular reference to ethical problems.
Behavior Genetics Of Psychopathology
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Author : Soo Hyun Rhee
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-03
Behavior Genetics Of Psychopathology written by Soo Hyun Rhee and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-03 with Psychology categories.
As a dynamic, interdisciplinary field, behavior genetics and its evolution are being followed closely by scientists across the psychological and medical domains. The discoveries surrounding the human genome and the advancement in molecular genetic technologies have led to studies becoming increasingly sophisticated and yielding yet more conclusive and useful results. This is certainly the case in the area of child and adult psychopathology. Behavior Genetics of Psychopathology summarizes the state of the field, examining the role of genes and environment as they affect common neurodevelopmental and psychiatric conditions. Emphasizing key research areas (comorbidities, twin studies, the integration of methods), the book assesses the current literature, offers up-to-date findings, sorts through lingering controversies, and identifies a clear future agenda for the field. Expertly-written chapters focus on issues of both general salience that shape behavior genetics of psychopathology, to specific disorders of major clinical importance, among them: ADHD: the view from quantitative genetic research. Autism spectrum disorders and their complex heterogeneity Genetic influences on anxiety and depression in childhood and adolescence. Evidence for etiologically-defined subgroups within the construct of antisocial behavior. Sleep and psychopathology: the reasons for their co-occurrence. Behavioral genetic approaches to the etiology of comorbidity. Epigenetics of psychopathology. This combination of timeliness and depth of coverage make Behavior Genetics of Psychopathology a frontline resource for behavior geneticists, psychologists, psychiatrists, and neuroscientists, and is perfectly suited to graduate students looking to join these fields.
Molecular Genetics Of Mental Disorders
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Author : Mike Briley
language : en
Publisher: CRC Press
Release Date : 2000-01-01
Molecular Genetics Of Mental Disorders written by Mike Briley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-01 with Science categories.
The field of molecular genetics is undergoing an explosion, not only in its fundamental understanding of the genetic processes but also in the potential applications as research tools and therapeutic approaches to many disease areas. Mental disorders are no exception and it is likely that most new psychotropic drugs will in future be derived through molecular genetic approaches. This book examines the place of molecular genetics in our understanding of the basic mechanisms of mental disorders and their role in highlighting new drug targets.
Psychiatric Genetics
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Author : Michael Arribas-Ayllon
language : en
Publisher: Routledge
Release Date : 2019-02-21
Psychiatric Genetics written by Michael Arribas-Ayllon and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-21 with Social Science categories.
Psychiatric genetics has become ‘Big Biology’. This may come as a surprising development to those familiar with its controversial history. From eugenic origins and contentious twin studies to a global network of laboratories employing high-throughput genetic and genomic technologies, biological research on psychiatric disorders has become an international, multidisciplinary assemblage of massive data resources. How did psychiatric genetics achieve this scale? How is it socially and epistemically organized? And how do scientists experience this politics of scale? Psychiatric Genetics: From Hereditary Madness to Big Biology develops a sociological approach of exploring the origins of psychiatric genetics by tracing several distinct styles of scientific reasoning that coalesced at the beginning of the twentieth century. These styles of reasoning reveal, among other things, a range of practices that maintain an extraordinary stability in the face of radical criticism, internal tensions and scientific disappointments. The book draws on a variety of methods and materials to explore these claims. Combining genealogical analysis of historical literature, rhetorical analysis of scientific review articles, interviews with scientists, ethnographic observations of laboratory practices and international conferences, this book offers a comprehensive and detailed exploration of both local and global changes in the field of psychiatric genetics.
Nature And Nurture In Mental Disorders Second Edition
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Author : Joel Paris, M.D.
language : en
Publisher: American Psychiatric Pub
Release Date : 2020-10-06
Nature And Nurture In Mental Disorders Second Edition written by Joel Paris, M.D. and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-06 with Medical categories.
Over the last two decades, spurred particularly by the decoding of the genome, neuroscience has advanced to become the primary basis of clinical psychiatry, even as environmental risk factors for mental disorders have been deemphasized. In this thoroughly revised, second edition of Nature and Nurture in Mental Disorders, the author argues that an overreliance on biology at the expense of environment has been detrimental to the field--that, in fact, the "nature versus nurture" dichotomy is unnecessary. Instead, he posits a biopsychosocial model that acknowledges the role an individual's predisposing genetic factors, interacting with environmental stressors, play in the etiology of many mental disorders. The first several chapters of the book provide an overview of the theories that affect the study of genes, the environment, and their interaction, examining what the empirical evidence has revealed about each of these issues. Subsequent chapters apply the integrated model to a variety of disorders, reviewing the evidence on how genes and environment interact to shape disorders including: - Depressive disorders- PTSD- Neurodevelopmental disorders- Eating disorders- Personality disorders By rejecting both biological and psychosocial reductionism in favor of an interactive model, Nature and Nurture in Mental Disorders offers practicing clinicians a path toward a more flexible, effective treatment model. And where controversy or debate still exist, an extensive reference list provided at the end of the book, updated for this edition to reflect the most current literature, encourages further study and exploration.
Neurogenetics Of Psychiatric Disorders
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Author : Akira Sawa
language : en
Publisher: CRC Press
Release Date : 2007-05-11
Neurogenetics Of Psychiatric Disorders written by Akira Sawa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-11 with Medical categories.
Translating bench-based research into effective bedside practice, this source provides a clear understanding of the neurobiology and neurogenetics of psychiatric disorders, the genes responsible for specific psychiatric disorders, and the implications of genetic roots and underlying biology on the development of new diagnostic approaches and treatment therapies.
The Behavioral Genetics Of Psychopathology
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Author : Kerry L. Jang
language : en
Publisher: Routledge
Release Date : 2005-03-23
The Behavioral Genetics Of Psychopathology written by Kerry L. Jang and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-23 with Medical categories.
New discoveries about the genetic underpinnings of many kinds of human experience are now continually being made. This book explores the impact of these discoveries on the ways in which the common mental disorders are best conceptualized and treated. Most people think of research in genetics as the search for genes. This is only one focus of effort, and even with the reliable identification of susceptibility genes, the clinical applications of their discovery, such as gene therapies and new drug development, are a long way off. For the present, the impact of genetic research on our understanding of mental illness is tied to our ability to estimate the effect of all genes by means of family, twin, and adoption studies. The results of these studies challenge some deeply cherished ideas and theories, and support others. Of course, the effect of genes is only half the equation. The role of experience, environment, and living conditions accounts for as much, often considerably more, of the variability in psychopathology. In this book, Kerry Jang attempts not to answer questions about what is "genetic" and what is not, but about what a knowledge of the relative influence of genes versus environment means at a psychological level of analysis--to show how it changes common assumptions about classification, etiology, diagnosis, and intervention. He first offers an overview of contemporary behavioral genetics, dispels common misconceptions, responds to the criticisms that have been leveled at this new field, and describes in basic terms how genetic and environmental effects are estimated and how susceptibility genes are pinpointed. He then points to new directions in which standard nosological systems are likely to evolve as new information about vulnerabilities and covariances emerges. Finally, he synthesizes and evaluates the consistency of the last decade's findings for the most common categories of psychopathology that have been studied by behavior geneticists: mood, personality, and anxiety disorders, substance abuse; and schizophrenia and the psychotic disorders. Clinicians and researchers alike need to understand the genetic influences on the feelings and behaviors they are seeking to change or study if they are to be effective in their work. The Behavioral Genetics of Psychopathology: A Clinical Guide empowers them with this understanding.