Genetic Risk Factors In Alzheimer S Disease

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Genetic Risk Factors In Alzheimer S Disease

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Author : Ágnes Fehér
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2011-01

Genetic Risk Factors In Alzheimer S Disease written by Ágnes Fehér and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01 with categories.

Alzheimer s disease is a progressive neurodegenerative disorder representing the most common type of dementia in the elderly population. According to the complex genetic model of late- onset, non-familial Alzheimer s disease, several heterogeneous susceptibility sets of genes may converge on the pathological processes that underlie the disease. Despite decades of intensive research the gene coding for apolipoprotein E is so far the only widely confirmed genetic risk factor for late- onset Alzheimer s disease. In this book we report the results of association studies investigating candidate gene variants supposed to be involved in Alzheimer s disease aetiology. Hypotheses regarding the role of the genes in the pathogenic pathways are discussed, taking into account the chromosomal localizations and the functions of the encoded proteins. As a long-term goal, identifying the genetic risk factors would help develop new strategies in the fields of prevention, diagnostics or genetics based pharmacology that can contribute to extend the lifespan and mental health of the elderly.

Identification And Functional Characterization Of Genetic Risk Factors In Alzheimer S Disease

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Author : Kerstin Eckart
language : en
Publisher:
Release Date : 2009

Identification And Functional Characterization Of Genetic Risk Factors In Alzheimer S Disease written by Kerstin Eckart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese

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Author : Lu-Hua Chen
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese written by Lu-Hua Chen and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.

This dissertation, "Genetic Risk Factors for Late-onset Alzheimer's Disease in Chinese" by Lu-hua, Chen, 陈璐华, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with genetic factors playing critical roles in its pathogenesis. Mutations in APP, PSEN1 and PSEN2 genes are confirmed to be causative risk factors for early-onset Alzheimer's disease (EOAD). For late-onset Alzheimer's disease (LOAD), growing evidence suggests it is caused by multiple genetic risk factors in corporation with the environmental exposures. Although, so far, APOE is the most well recognized common genetic risk factor for LOAD, other susceptible candidate genes, such as CR1, CLU and PICALM, have recently been identified in Caucasians using genome-wide association approach. In order to have a better understanding on the genetic components of LOAD in Chinese as well as identify other potential genetic risk factors for Chinese ethnic population, we conducted a case-control study using candidate gene association approach. In view of increasing evidence on the neural protective effects of sex steroid hormones both in vivo and in vitro, we hypothesized variations on sex steroid metabolic pathway genes were associated with LOAD. Four candidate genes (ESR1, ESR2, CYP19A1, CYP11A1) were evaluated based on 462 cases and 350 non-demented controls. Apart from consistent result for APOE, polymorphisms in ESR2 and CYP11A1 were found to be significantly associated with the disease. When stratification according to gender, marginally significant associations were detected for ESR1 and ESR2 variants in men while CYP11A1 variants relevant to LOAD risk were detected exclusively in women. Additionally, genotypic and phenotypic correlation analysis revealed CYP19A1 was significantly relevant to serum 17-estradiol (E2) levels in 689 subgroup participants, especially in 400 LOAD patients of subgroup. Further gene-level analyses based on whole sample confirmed above disease association for ESR2 and CYP11A1 and pathway-level analyses highlighted the impact of sex steroid metabolic pathway on disease predisposition. The independent follow-up study for CR1, CLU and PICALM previously reported by genome-wide association study (GWAS) in Caucasians was conducted in the same Chinese cohort. Similar to the Caucasian cohort, polymorphisms in CR1 and CLU were found to be significantly different between cases and non-demented controls. However, significant disease association for PICAML was detected only in the APOE ε4 (-) subgroup of our Chinese cohort. In conclusions, genetic abnormalities were founded in Chinese LOAD patients. In addition to confirmation disease susceptibility for APOE, CR1, CLU and PICALM, we were first to report the associations between several sex steroid metabolic pathway genes and LOAD. This valuable genetic information obtained from Chinese patients may lead to the development of novel diagnostic strategies and therapeutic interventions in LOAD. DOI: 10.5353/th_b4961758 Subjects: Alzheimer's disease - Genetic aspects

Identification Of Genetic Risk Factors For Alzheimer S Disease In The Chinese Population By Whole Genome Sequencing

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Author : Xiaopu Zhou
language : en
Publisher:
Release Date : 2018

Identification Of Genetic Risk Factors For Alzheimer S Disease In The Chinese Population By Whole Genome Sequencing written by Xiaopu Zhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

Characterising The Effects Of Genetic Risk Factors Of Alzheimer S Disease On Synaptic Transmission

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Author : Luca Biasetti
language : en
Publisher:
Release Date : 2020

Characterising The Effects Of Genetic Risk Factors Of Alzheimer S Disease On Synaptic Transmission written by Luca Biasetti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese

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Author : Lu-hua Chen
language : en
Publisher:
Release Date : 2012

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese written by Lu-hua Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Alzheimer's disease categories.

Genetic Risk Factors In Sporadic Alzheimer S Disease

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Author : Louise Tilley
language : en
Publisher:
Release Date : 2000

Genetic Risk Factors In Sporadic Alzheimer S Disease written by Louise Tilley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese

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Author : Lu-hua Chen
language : en
Publisher:
Release Date : 2012

Genetic Risk Factors For Late Onset Alzheimer S Disease In Chinese written by Lu-hua Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Alzheimer's disease categories.

Genetic Risk Factors In Alzheimer S Disease A Hypothesis Based Candidate Gene Approach

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Author :
language : en
Publisher:
Release Date : 2002

Genetic Risk Factors In Alzheimer S Disease A Hypothesis Based Candidate Gene Approach written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Alzheimer S Disease

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Author : Zaven S Khachaturian
language : en
Publisher: CRC Press
Release Date : 2019-06-04

Alzheimer S Disease written by Zaven S Khachaturian and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.

Published in 1996: Alzheimer's disease is characterized by memory disturbances and changes in personality and is associated with aging, although it can occur in people under 65. It is a progressive disease, painful to witness as the patient's health declines. Alzheimer's Disease: Cause(s), Diagnosis, and Care, with its complete and authoritative discussions, will help you understand all facets of this complex disease. This book addresses a broad spectrum of topics ranging from diagnosis, causes, treatment, epidemiology, genetics, risk factors, and care and management. Alzheimer's Disease: Cause(s), Diagnosis, and Care is intended for a diverse audience, including practitioners and students, family members, and everyone who is concerned about this disease.