Genetically Engineered Bone Marrow Stromal Cells And Collagen Mimetic Scaffold Modification For Healing Critically Sized Bone Defects
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Genetically Engineered Bone Marrow Stromal Cells And Collagen Mimetic Scaffold Modification For Healing Critically Sized Bone Defects
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Author : Abigail M. Wojtowicz
language : en
Publisher:
Release Date : 2009
Genetically Engineered Bone Marrow Stromal Cells And Collagen Mimetic Scaffold Modification For Healing Critically Sized Bone Defects written by Abigail M. Wojtowicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Bone regeneration categories.
Non-healing bone defects have a significant socioeconomic impact in the U.S. with approximately 600,000 bone grafting procedures performed annually. Autografts and allografts are clinically the most common treatments; however, autologous donor bone is in limited supply, and allografts often have poor mechanical properties. Therefore, tissue engineering and regenerative medicine strategies are being developed to address issues with clinical bone grafting. The overall objective of this work was to develop bone tissue engineering strategies that enhance healing of orthotopic defects by targeting specific osteogenic cell signaling pathways. The general approach included the investigation of two different tissue engineering strategies, which both focused on directed osteoblastic differentiation to promote bone formation. In the first cell-based strategy, we hypothesized that constitutive overexpression of the osteoblast-specific transcription factor, Runx2, in bone marrow stromal cells (BMSCs) would promote orthotopic bone formation in vivo. We tested this hypothesis by delivering Runx2-modified BMSCs on synthetic scaffolds to critically-sized defects in rats. We found that Runx2-modified BMSCs significantly increased orthotopic bone formation compared to empty defects, cell-free scaffolds and unmodified BMSCs. This gene therapy approach to bone regeneration provides a mineralizing cell source which has clinical relevance.
Bone Tissue Engineering
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Author : Jeffrey O. Hollinger
language : en
Publisher: CRC Press
Release Date : 2004-10-14
Bone Tissue Engineering written by Jeffrey O. Hollinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-14 with Medical categories.
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Functional Tissue Engineering
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Author : Farshid Guilak
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-09
Functional Tissue Engineering written by Farshid Guilak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-09 with Science categories.
-Softcover reprint of a successful hardcover reference (370 copies sold) -Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering -Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology
Advanced Healthcare Materials
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Author : Ashutosh Tiwari
language : en
Publisher: John Wiley & Sons
Release Date : 2014-05-09
Advanced Healthcare Materials written by Ashutosh Tiwari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Technology & Engineering categories.
Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Regenerative Pharmacology
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Author : George J. Christ
language : en
Publisher: Cambridge University Press
Release Date : 2013-04-15
Regenerative Pharmacology written by George J. Christ and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Medical categories.
Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.
Polymer Based Additive Manufacturing
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Author : Declan M. Devine
language : en
Publisher: Springer Nature
Release Date : 2019-09-16
Polymer Based Additive Manufacturing written by Declan M. Devine and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-16 with Medical categories.
This book aims to give readers a basic understanding of commonly used additive manufacturing techniques as well as the tools to fully utilise the strengths of additive manufacturing through the modelling and design phase all the way through to post processing. Guidelines for 3D-printed biomedical implants are also provided. Current biomedical applications of 3D printing are discussed, including indirect applications in the rapid manufacture of prototype tooling and direct applications in the orthopaedics, cardiovascular, drug delivery, ear-nose-throat, and tissue engineering fields. Polymer-Based Additive Manufacturing: Biomedical Applications is an ideal resource for students, researchers, and those working in industry seeking to better understand the medical applications of additive manufacturing.
Stem Cells And Biomaterials For Regenerative Medicine
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Author : Marek J. Los
language : en
Publisher: Academic Press
Release Date : 2018-11-07
Stem Cells And Biomaterials For Regenerative Medicine written by Marek J. Los and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-07 with Science categories.
Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials
Developments And Applications Of Calcium Phosphate Bone Cements
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Author : Changsheng Liu
language : en
Publisher: Springer
Release Date : 2017-10-20
Developments And Applications Of Calcium Phosphate Bone Cements written by Changsheng Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-20 with Technology & Engineering categories.
This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Cutting Edge Enabling Technologies For Regenerative Medicine
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Author : Heung Jae Chun
language : en
Publisher: Springer
Release Date : 2018-10-24
Cutting Edge Enabling Technologies For Regenerative Medicine written by Heung Jae Chun and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Medical categories.
This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
Biomaterial Supported Tissue Reconstruction Or Regeneration
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Author : Mike Barbeck
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-05-22
Biomaterial Supported Tissue Reconstruction Or Regeneration written by Mike Barbeck and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-22 with Technology & Engineering categories.
This book is a collection of chapters from different biomaterial experts, including their design, new insights into the molecular basis of their interaction with the organism, and their successful application. The chapters have been organized to illustrate different aspects of multidisciplinary biomaterial science. Thus, this book should give readers a view into the different biomaterial disciplines and methodologies that are needed for specific clinical applications.