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Genetics Of Hypertension


Genetics Of Hypertension
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Genetics Of Hypertension


Genetics Of Hypertension
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Author : Anna F. Dominiczak
language : en
Publisher: Elsevier Health Sciences
Release Date : 2007-01-01

Genetics Of Hypertension written by Anna F. Dominiczak and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.


Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.



Genetics Of Hypertension


Genetics Of Hypertension
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Author : Xi Cheng
language : en
Publisher: Biota Publishing
Release Date : 2015-08-01

Genetics Of Hypertension written by Xi Cheng and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-01 with Medical categories.


Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Essential Hypertension is heritable and, thereby, classical genetic approaches have been applied on both human and other mammalian models of hypertension to map the locations of the allelic variants within quantitative trait loci for blood pressure. The post genome era has further elevated this area of research into large-scale genome-wide association studies of hypertension in humans. Collectively, these studies have resulted in the prioritization and cataloging of several genomic regions containing allelic variants as candidates linked or associated with essential hypertension. Further, they are providing evidence to suggest that the inheritance of hypertension is rather complex, encompassing multiple variants both within protein-coding and non-coding annotations, each of which may act independently or interactively with other genes and/or environmental factors to differentially regulate blood pressure. This book provides an overview of the various methods employed to study the genetics of hypertension and discuss the progress and prospects of this area of research that may contribute towards individualized clinical management of hypertension in the future.



Genetics And Pathophysiology Of Essential Hypertension


Genetics And Pathophysiology Of Essential Hypertension
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Author : Madhu Khullar
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-09

Genetics And Pathophysiology Of Essential Hypertension written by Madhu Khullar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-09 with Medical categories.


This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.



Molecular Genetics Of Hypertension


Molecular Genetics Of Hypertension
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-10-06

Molecular Genetics Of Hypertension written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-06 with Science categories.


This is a rapidly expanding research area, with most current publications existing as journal articles, or as single chapters in larger volumes. This will be one of the first books to bring all this information together into a comprehensive review volume, aimed at both researchers and clinicians. Hypertension is a condition in humans which is characterized by persistently high arterial blood pressure (over 140/90 mm Hg). Affected individuals are at risk from heart disease, stroke and kidney failure. This important disease affects a huge number of people worldwide, and therefore the study of the disease is of vital clinical importance. Hypertension is a genetically determined disease, with many other contributing factors. Research has expanded rapidly in this area, particularly over the last decade, and there are continuing advances in our understanding of the disease.



Role Of Genomics In The Management Of Hypertension


Role Of Genomics In The Management Of Hypertension
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Author : Paolo Mulatero
language : en
Publisher: MDPI
Release Date : 2021-01-21

Role Of Genomics In The Management Of Hypertension written by Paolo Mulatero and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Science categories.


Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.



Experimental And Genetic Models Of Hypertension


Experimental And Genetic Models Of Hypertension
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Author : Wybren de Jong
language : en
Publisher:
Release Date : 1994

Experimental And Genetic Models Of Hypertension written by Wybren de Jong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.


Hardbound. This volume is a worthy successor to volume 4 by virtue of its focus on the recent conceptual revolution in fundamental hypertension research. Without neglecting the heritage of earlier achievements, it highlights such brilliant breakthroughs in molecular genetics as the creation of transgenic animals as a source of a new pathogenesis of hypertension.A core of (patho)physiological mechanisms operative in experimental hypertension is provided, including several which act to maintain a normotensive state. The volume provides background and technical information on the use of different models of hypertension in a variety of animal species. A wealth of new information regarding the several different complications observed in genetic and other models of hypertension, as well as new animal models dedicated to these aspects, are also presented. Furthermore, new chapters addressing genotyping and the use of transgenics in hypertension are included.



Report Of The Hypertension Task Force Current Research And Recommendations From The Task Force Subgroups On Pediatrics Genetics


Report Of The Hypertension Task Force Current Research And Recommendations From The Task Force Subgroups On Pediatrics Genetics
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Author : National Heart, Lung, and Blood Institute. Hypertension Task Force
language : en
Publisher:
Release Date : 1979

Report Of The Hypertension Task Force Current Research And Recommendations From The Task Force Subgroups On Pediatrics Genetics written by National Heart, Lung, and Blood Institute. Hypertension Task Force and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Hypertension categories.


Abstract: The current state of hypertension research is reviewed, focusing on 12 special hypertension concerns and covering each concern with the following: an evaluation of the current literature, recommendations for future research, and a comprehensive list of references. Volume 1, written for the public, examines hypertension as both a public health and a research problem, and Volume 2, written for the biomedical community, explores general recommendations, and summaries of scientific reports are covered in volumes 3 through 9.



Genes And Genetics In Hypertension And Vascular Disease


Genes And Genetics In Hypertension And Vascular Disease
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Author : Hermann Haller
language : en
Publisher:
Release Date : 1998

Genes And Genetics In Hypertension And Vascular Disease written by Hermann Haller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.




Genetics Of Hypertension


Genetics Of Hypertension
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Author : Anna F. Dominiczak
language : en
Publisher: Elsevier Health Sciences
Release Date : 2007

Genetics Of Hypertension written by Anna F. Dominiczak and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.


Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.



Genetic Immune And Molecular Predisposition To Hypertension


Genetic Immune And Molecular Predisposition To Hypertension
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Author : P. M. Frossard
language : en
Publisher: VSP
Release Date : 1999-01-01

Genetic Immune And Molecular Predisposition To Hypertension written by P. M. Frossard and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Medical categories.