Gerhard Domagk And The Discovery Of Sulfa
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Gerhard Domagk And The Discovery Of Sulfa
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Author : John Bankston
language : en
Publisher: Mitchell Lane Publishers
Release Date : 2003
Gerhard Domagk And The Discovery Of Sulfa written by John Bankston and has been published by Mitchell Lane Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Juvenile Nonfiction categories.
A biography of the German scientist responsible for developing the use of sulfa as an antibiotic in the early twentieth century.
The First Miracle Drugs
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Author : John E. Lesch
language : en
Publisher:
Release Date : 2007
The First Miracle Drugs written by John E. Lesch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
The Demon Under The Microscope
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Author : Thomas Hager
language : en
Publisher: Harmony
Release Date : 2006
The Demon Under The Microscope written by Thomas Hager and has been published by Harmony this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Biography & Autobiography categories.
Fast-paced, suspenseful, and utterly satisfying, this is the sweeping historyof the discovery of the first antibiotic and its dramatic effect on the worldof medicine and beyond.
Physiology Or Medicine 1922 1941
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Author : Jan Lindsten
language : en
Publisher: World Scientific
Release Date : 1999
Physiology Or Medicine 1922 1941 written by Jan Lindsten and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Phenotypic Drug Discovery
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Author : Beverley Isherwood
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-09
Phenotypic Drug Discovery written by Beverley Isherwood and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Medical categories.
Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.
Antibiotic Discovery And Development
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Author : Thomas J. Dougherty
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-18
Antibiotic Discovery And Development written by Thomas J. Dougherty and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-18 with Medical categories.
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
The Antibiotic Paradox
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Author : Stuart B. Levy
language : en
Publisher: Springer
Release Date : 2013-11-11
The Antibiotic Paradox written by Stuart B. Levy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The discovery of antibiotics heralded medicine's triumph over previously fatal diseases that once destroyed entire civilizations - thus earning their reputation as miracle drugs. But today, the terrifying reality of antibiotic-resistant bacteria resulting from our widespread misuse of antibiotics forewarns us that the miracle may be coming to an end. The seemingly innocent consumer who demands antibiotics to treat nonbacterial diseases such as the common cold or plays doctor by saving old prescriptions for later use is paving the way for a future of antibiotic failure. "What harm can it do?" is a popular refrain of people worldwide as they pop another antibiotic pill. Dr. Stuart Levy - the leading international expert on hazards of antibiotic misuse - reveals how this cavalier and naive attitude about the power of antibiotics can have deadly consequences. He explains that we are presently witnessing a massive evolutionary change in bacteria. This build-up of new antibiotic-resistant bacteria in individuals and the environment worldwide is an insidious and silent process. Thus, unwittingly consumers encounter resistant bacteria in their meat, poultry, fish, and vegetables. Unregulated dispensing of antibiotics in poorer countries breeds countless more resistant strains. Since bacteria recognize no geographical boundaries, resistant forms can travel the globe. If this trend continues to grow unchecked, we may someday find that all of our antibiotics are obsolete. Today doctors can no longer expect that their first choice of antibiotic for women's urinary tract infections or children's ear infections will work. Similarly, cancer therapy is rendered useless if patients are unable to fight infections that are sometimes resistant to eight to ten different drugs. In developing countries, people are now dying of previously treatable diseases that are no longer responsive to traditional antibiotics. These problems are just a harbinger of what will come if we do not act now. Dr. Levy, recognized by The New Yorker for his superb contributions to this field, is sending out an urgent message that the world cannot afford to ignore any longer. The goal of this unprecedented investigation into the dangers of antibiotic misuse is to protect the world community from resistant infections and ensure the success of antibiotics for generations to come
Nature At War
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Author : Thomas Robertson
language : en
Publisher: Cambridge University Press
Release Date : 2020-04-02
Nature At War written by Thomas Robertson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-02 with History categories.
"World War II was the largest and most destructive conflict in human history. It was an existential struggle that pitted irreconcilable political systems and ideologies against one another across the globe in a decade of violence unlike any other. There is little doubt today that the United States had to engage in the fighting, especially after the Japanese attack on Pearl Harbor on December 7, 1941. The conflict was, in the words of historians Allan Millett and Williamson Murray, "a war to be won." As the world's largest industrial power, the United States put forth a supreme effort to produce the weapons, munitions, and military formations essential to achieving victory. When the war finally ended, the finale signaled by atomic mushroom clouds over Hiroshima and Nagasaki, upwards of 60 million people had perished in the inferno. Of course, the human toll represented only part of the devastation; global environments also suffered greatly. The growth and devastation of the Second World War significantly changed American landscapes as well. The war created or significantly expanded a number of industries, put land to new uses, spurred urbanization, and left a legacy of pollution that would in time create a new term: Superfund site"--
Essential Microbiology
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Author : Stuart Hogg
language : en
Publisher: John Wiley & Sons
Release Date : 2013-06-10
Essential Microbiology written by Stuart Hogg and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-10 with Science categories.
Essential Microbiology 2nd Edition is a fully revised comprehensive introductory text aimed at students taking a first course in the subject. It provides an ideal entry into the world of microorganisms, considering all aspects of their biology (structure, metabolism, genetics), and illustrates the remarkable diversity of microbial life by devoting a chapter to each of the main taxonomic groupings. The second part of the book introduces the reader to aspects of applied microbiology, exploring the involvement of microorganisms in areas as diverse as food and drink production, genetic engineering, global recycling systems and infectious disease. Essential Microbiology explains the key points of each topic but avoids overburdening the student with unnecessary detail. Now in full colour it makes extensive use of clear line diagrams to clarify sometimes difficult concepts or mechanisms. A companion web site includes further material including MCQs, enabling the student to assess their understanding of the main concepts that have been covered. This edition has been fully revised and updated to reflect the developments that have occurred in recent years and includes a completely new section devoted to medical microbiology. Students of any life science degree course will find this a concise and valuable introduction to microbiology.
The Burdens Of Disease
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Author : J. N. Hays
language : en
Publisher: Rutgers University Press
Release Date : 2009-10-15
The Burdens Of Disease written by J. N. Hays and has been published by Rutgers University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-15 with Medical categories.
A review of the original edition of The Burdens of Disease that appeared in ISIS stated, "Hays has written a remarkable book. He too has a message: That epidemics are primarily dependent on poverty and that the West has consistently refused to accept this." This revised edition confirms the book's timely value and provides a sweeping approach to the history of disease. In this updated volume, with revisions and additions to the original content, including the evolution of drug-resistant diseases and expanded coverage of HIV/AIDS, along with recent data on mortality figures and other relevant statistics, J. N. Hays chronicles perceptions and responses to plague and pestilence over two thousand years of western history. Disease is framed as a multidimensional construct, situated at the intersection of history, politics, culture, and medicine, and rooted in mentalities and social relations as much as in biological conditions of pathology. This revised edition of The Burdens of Disease also studies the victims of epidemics, paying close attention to the relationships among poverty, power, and disease.