Glial Plasticity In Depression
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Glial Plasticity In Depression
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Author : João F. Oliveira
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-24
Glial Plasticity In Depression written by João F. Oliveira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-24 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.
Glial Plasticity In Depression
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Author :
language : en
Publisher:
Release Date : 2016
Glial Plasticity In Depression written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.
Major Depressive Disorder
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Author : Yong-Ku Kim
language : en
Publisher: Springer Nature
Release Date : 2021-04-08
Major Depressive Disorder written by Yong-Ku Kim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-08 with Medical categories.
This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.
The Hippocampus
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Author : Ales Stuchlik
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-07-11
The Hippocampus written by Ales Stuchlik and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-11 with Medical categories.
The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
Cognitive Enhancement In Schizophrenia And Related Disorders
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Author : Matcheri Keshavan
language : en
Publisher: Cambridge University Press
Release Date : 2019-03-21
Cognitive Enhancement In Schizophrenia And Related Disorders written by Matcheri Keshavan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-21 with Medical categories.
A practical guide on how to assess and treat schizophrenia and related disorders using cognitive rehabilitation.
The Neurobiological Basis Of Suicide
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Author : Yogesh Dwivedi
language : en
Publisher: CRC Press
Release Date : 2012-06-25
The Neurobiological Basis Of Suicide written by Yogesh Dwivedi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-25 with Medical categories.
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment
Rapid Acting Antidepressants
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-06-29
Rapid Acting Antidepressants written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-29 with Medical categories.
The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Brain Plasticity And Behavior
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Author : Bryan Kolb
language : en
Publisher: Psychology Press
Release Date : 1995
Brain Plasticity And Behavior written by Bryan Kolb and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Brain categories.
First Published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.
Translational Research In Traumatic Brain Injury
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Author : Daniel Laskowitz
language : en
Publisher: CRC Press
Release Date : 2015-12-01
Translational Research In Traumatic Brain Injury written by Daniel Laskowitz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Medical categories.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Neuroplasticity
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Author : Jean-Paul Macher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-02
Neuroplasticity written by Jean-Paul Macher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-02 with Medical categories.
New research into neuroplasticity is a fascinating new research angle that could lead to improvements in therapy for the depressive disorders. In this volume, researchers in the field contribute chapters examining different aspects of this phenomenon. Figures and tables help explain complicated concepts This book provides a new angle on the treatment of depressive disorders