Glioblastoma

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Glioblastoma Multiforme

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Author : James Markert
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2005

Glioblastoma Multiforme written by James Markert and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Brain Neoplasms categories.

Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more.

Glioblastoma A Guide For Patients And Loved Ones

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Author : Glioblastoma – A Guide for Patients and Loved Ones
language : en
Publisher: Gideon Burrows
Release Date : 2021-04-01

Glioblastoma A Guide For Patients And Loved Ones written by Glioblastoma – A Guide for Patients and Loved Ones and has been published by Gideon Burrows this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.

Glioblastoma and anaplastic astrocytoma are two of the most common form of brain tumours in adults. Too often they can be life changing, even life limiting for patients, wreaking devastation on their families. This readable, moving and non technical guide is your comprehensive patient focussed guide to these obstinate brain cancers. It covers everything from getting an accurate diagnosis, to dealing with the physical, mental and emotional impact of the disease. From treatment options and how to cope with their side effects, to newly developing techniques and future research. This book presents an honest and realistic picture, with a personal approach. Featuring dozens of personal testimonies from those with these high grade brain tumours and their loved ones, the book offers information, reassurance and support on these, the most complex of brain tumours.

Fast Facts Glioblastoma

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Author : Mairéad McNamara
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2020-02-26

Fast Facts Glioblastoma written by Mairéad McNamara and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-26 with Medical categories.

Glioblastoma (also known as glioblastoma multiforme) is a malignant intrinsic tumor thought to arise from populations of stem/progenitor cells in the brain. It is the most common aggressive intrinsic brain tumor in adults, with the potential to spread rapidly within the brain. Patients with glioblastoma face a poor prognosis, with median overall survival of approximately 15 months. However, our growing understanding of the molecular biology of gliomas means that this outlook may be improving. The identification of clinically relevant subgroups defined by specific genetic mutations is challenging the traditional delineation between low- and high-grade gliomas that has been based on histological appearance and imaging. Indeed, it is becoming clear that, as a molecular entity, a glioblastoma, which by traditional classification is a grade IV glioma, may present with a lower grade initially and then become more aggressive – an important addition to the established concept. The care of a patient with a glioblastoma requires a coordinated approach delivered by a multidisciplinary team, with the aim of maintaining quality of life for as long as possible. Here, we provide a concise overview of the diagnosis and management of glioblastoma, as well as discussion of our emerging understanding of the molecular drivers that are helping us to delineate different patient subgroups. These subgroups will, hopefully, allow more targeted treatments in the future. This resource will be of interest to all those involved in caring for patients with this aggressive brain tumor, including neurologists, neurosurgeons, neuro-oncologists, radiation oncologists, palliative care specialists, specialist nurses and medical students. Contents: • Epidemiology, pathophysiology and classification • Clinical presentation • Diagnosis • Management • Treatment of associated conditions • Emerging research and treatment

A Statistic Of One

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Author : Stephen Hatrak
language : en
Publisher: iUniverse
Release Date : 2012-05-11

A Statistic Of One written by Stephen Hatrak and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-11 with Biography & Autobiography categories.

A Statistic of One: My Walk with Glioblastoma Multiforme traces Stephen Hatraks life from his diagnosis of glioblastoma multiforme, the deadliest of malignant brain tumors, to the present. He chronicles the trials and tribulations he faced and the losses he suffered along his journey. Faith and inner strength are formidable allies in overcoming any tragedy in ones life, and they played vital roles in his struggle. He was told from the start that the he might have twelve months to live; even so, he defi ed the odds and, six years later, is telling his own story. Despite the dire statistics associated with a diagnosis of glioblastoma, there are several stories of long-term survival; these stories gave him hope that this cancer could be tamed. To overcome this challenge in his life, he had to believe in himself and fi nd his inner sixth sense to strengthen his resolve. Along the way, he learned that life with brain cancer could be tough, but that he could be even tougher. What cancer cannot do.separate me from my soul, squash my spirit, and stop the sun from rising in the east and setting in the west; creating new tomorrows and new opportunities. A Statistic of One is an uplifting story of faith and perseverance; how we cope with challenge will determine how we move forward and live life to its fullest.

Tumors Of The Central Nervous System Volume 1

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Author : M. A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-23

Tumors Of The Central Nervous System Volume 1 written by M. A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-23 with Medical categories.

The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.

Glioblastoma

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Author : Swapan K. Ray
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-31

Glioblastoma written by Swapan K. Ray and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-31 with Medical categories.

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Glioblastoma Part Ii Molecular Targets And Clinical Trials An Issue Of Neurosurgery Clinics Of North America

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Author : Linda M. Liau
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-04-08

Glioblastoma Part Ii Molecular Targets And Clinical Trials An Issue Of Neurosurgery Clinics Of North America written by Linda M. Liau and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-08 with Medical categories.

This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include—but are not limited to—Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

Tumors Of The Central Nervous System Volume 2

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Author : M.A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-03

Tumors Of The Central Nervous System Volume 2 written by M.A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-03 with Medical categories.

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.

Glioblastoma Resistance To Chemotherapy Molecular Mechanisms And Innovative Reversal Strategies

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Author : Ramasamy Paulmurugan
language : en
Publisher: Academic Press
Release Date : 2021-06-25

Glioblastoma Resistance To Chemotherapy Molecular Mechanisms And Innovative Reversal Strategies written by Ramasamy Paulmurugan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-25 with Science categories.

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

New Insights Into Glioblastoma

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Author : Carla Vitorino
language : en
Publisher: Elsevier
Release Date : 2023-05-17

New Insights Into Glioblastoma written by Carla Vitorino and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Science categories.

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment. Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma Includes overviews to help readers apply information in their research Encompasses summarizing diagrams and real-world examples to facilitate comprehension and enhance the applicability of the content