Growth Factors And Alzheimer S Disease

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Growth Factors And Alzheimer S Disease

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Author : Franz Hefti
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08

Growth Factors And Alzheimer S Disease written by Franz Hefti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.

The study of the relationships between neurotrophic factors (NGF, FGF, amyloid) and neurodegenerative disorders (especially Alzheimer's disease) is of major importance not only for understanding the pathogenesis of the latter, but also for the pharmacological approach to this disease. Information on the subject stemming from the symposium in Strasbourg in April, 1990, organized by the Fondation IPSEN is presented in this book. It provides stimulating hypotheses about the possible role of growth factors in the generation of senile plaques, the process of degeneration and regeneration in Alzheimer's disease, the expression of the gene of NGF and the possible use of NGF in treatment.

Growth Factors As Drugs For Neurological And Sensory Disorders

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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30

Growth Factors As Drugs For Neurological And Sensory Disorders written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.

Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.

Nerve Growth Factor Aging And Alzheimer S Disease

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Author : Martin A. Bruno
language : en
Publisher:
Release Date : 2007

Nerve Growth Factor Aging And Alzheimer S Disease written by Martin A. Bruno and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Growth Factors And Psychiatric Disorders

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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15

Growth Factors And Psychiatric Disorders written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.

Quantification Of Nerve Growth Factor In Alzheimer S Disease

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Author : Kathleen Helen Andersen
language : en
Publisher:
Release Date : 1991

Quantification Of Nerve Growth Factor In Alzheimer S Disease written by Kathleen Helen Andersen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Alzheimer's disease categories.

Aging And Alzheimer S Disease

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Author : International Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting
language : en
Publisher:
Release Date : 1991

Aging And Alzheimer S Disease written by International Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.

These 66 papers and poster presentations deal with sensory systems in Alzheimer's disease; neuronal metabolic failure; signals for neuronal growth; disordered amyloid metabolism; new topics in dementia; therapeutics; epidemiology; behaviour and neuro-imaging; chemistry; neuropathology; molecular biology; human pharmacology; and animal pharmacology.

Treatment Of Dementias

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Author : Edwin M. Meyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Treatment Of Dementias written by Edwin M. Meyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Alzheimer's disease is one the foremost health problems facing every society fortunate enough to attain a level of medical care that ensures an average lifespan of over 70 years of age. The cause of the disease remains unknown, and no single therapeutic approach has yet been found highly efficacious. Indeed, as the complexity of its effects on brain neuronal systems becomes elucidated, the concept emerges that Alzheimer's disease may be an umbrella term for multiple Alzheimer's-type syndromes that can be differentiated based on etiology (hereditary versus sporadic), neurochemical deficits, and extent of pathology. Whether one or more disease processes is involved, it seems increasingly unlikely that any single drug will provide efficacious relief across the broad spectrum of symptoms reflected in large subject populations. Rational therapeutic approaches may yield long term amelioration of many symptoms in selected groups of patients; and individual symptoms may be ameliorated in larger populations. Multiple approaches may be combined to optimize therapeutic effects. For example, a variety of approaches remain focused on restoration of cholinergic neurodegeneration and enhancing cholinergic neurotransmission, whereas other approaches attempt to retard the of the brain that occurs during Alzheimer's disease. Chapters cover continuous degeneration topics from growth factor secretion of proteases, which could modify amyloid processing, to neuronal gene delivery using viral vectors. The breadth and thoroughness of the chapters truly embrace a broad spectrurn of models, pathological mechanisms and therapeutic approaches.

Molecular Aspects Of Development And Aging Of The Nervous System

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Author : Jean Lauder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21

Molecular Aspects Of Development And Aging Of The Nervous System written by Jean Lauder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.

The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.

Novel Approaches To The Treatment Of Alzheimer S Disease

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Author : E. Meyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Novel Approaches To The Treatment Of Alzheimer S Disease written by E. Meyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.

Alzheimer's disease afflicts up to 1 in 5 people over the age of 65 years and causes untold suffering of the patient and their family. The cause of this disease is unknown; indeed, evidence increasingly suggests that there may be multiple Alzheimer-type syndromes with different etiologies, analogous to different types of psychosis. Currently there are no means to prevent the disease, slow its progress or reverse its neurodegenerative consequences. With few exceptions, clinical trials of a variety of compounds have resulted in patient responses that are disappointing with respect to both the proportion of responders and the magnitude of the responses. Novel approaches to the treatment of Alzheimer's disease are clearly warranted. For this reason, we organized the First Suncoast Workshop on the Neurobiology of Aging in St. Petersburg, Florida, which took place from February 26-March 1, 1989. This workshop focused on novel treatments and models for Alzheimer's disease and represented a cooperative venture among academia, government and industry, both in its participants and sponsorship. The Center for the Neurobiology of Aging at the University of Florida, the National Institute on Aging and Taiho Pharmaceutical Corporation in Japan sponsored the workshop in which scientists from the North America, Europe, Japan and other parts of Asia participated.

Clinical Applications Of Neurotrophic Factors

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Author : Stuart C. Apfel
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1997

Clinical Applications Of Neurotrophic Factors written by Stuart C. Apfel and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.