Guia A Hist Ria Ed 05 Navio
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Snakes Of The World
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Author : Jeff Boundy
language : en
Publisher: CRC Press
Release Date : 2020-08-27
Snakes Of The World written by Jeff Boundy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with Nature categories.
Snakes of the World: A Catalogue of Living and Extinct Species, published in 2014, was the first catalogue of its kind and covered all living and fossil snakes described between 1758 and 2012. This new volume will be a supplement to this important herpetological reference and will include new published data on snakes named and recognized since 2012. Key Features Supplements and updates Wallach et al. – Snakes of the World – the only work to cover all living snakes in the world. Includes updates for fossil snakes named since the publication of Wallach et al. Summarizes the systematic snake literature published since the appearance of Wallach et al. Genera and species are listed alphabetically for ease of reference. Related Titles Wallach, V., K. L. Williams, and J. Boundy. Snakes of the World: A Catalogue of Living and Extinct Species (ISBN 978-1-138-03400-6) Aldridge, R. D. and D. M. Sever, eds. Reproductive Biology and Phylogeny of Snakes (ISBN 978-1-57808-701-3) Caldwell, M. W. The Origin of Snakes: Morphology and the Fossil Record (ISBN 978-1-4822-5134-0)
Biodiversity Of Angola
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Author : Brian J. Huntley
language : en
Publisher: Springer
Release Date : 2019-02-20
Biodiversity Of Angola written by Brian J. Huntley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-20 with Science categories.
This open access multi-authored book presents a 'state of the science' synthesis of knowledge on the biodiversity of Angola, based on sources in peer-reviewed journals, in books and where appropriate, unpublished official reports. The book identifies Angola as one of the most biologically diverse countries in Africa, but notes that its fauna, flora, habitats and the processes that drive the dynamics of its ecosystems are still very poorly researched and documented. This 'state of the science' synthesis is for the use of all students of Angola's biodiversity, and for those responsible for the planning, development and sustainable management of the country's living resources. The volume brings together the results of expeditions and research undertaken in Angola since the late eighteenth century, with emphasis on work conducted in the four decades since Angola's independence in 1975. The individual chapters have been written by leaders in their fields, and reviewed by peers familiar with the region.
Fundamentals Of Analytical Chemistry
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Author : Douglas A. Skoog
language : en
Publisher: Cengage Learning
Release Date : 2013-01-01
Fundamentals Of Analytical Chemistry written by Douglas A. Skoog and has been published by Cengage Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-01 with Chemistry, Analytic categories.
Known for its readability and systematic, rigorous approach, this fully updated FUNDAMENTALS OF ANALYTICAL CHEMISTRY, 9E, International Edition offers extensive coverage of the principles and practices of analytic chemistry and consistently shows students its applied nature. The book's award-winning authors begin each chapter with a story and photo of how analytic chemistry is applied in industry, medicine, and all the sciences. To further reinforce student learning, a wealth of dynamic photographs by renowned chemistry photographer Charlie Winters appear as chapter-openers and throughout the text. Incorporating Excel spreadsheets as a problem-solving tool, the Ninth Edition is enhanced by a chapter on Using Spreadsheets in Analytical Chemistry, updated spreadsheet summaries and problems, an "Excel Shortcut Keystrokes for the PC" insert card, and a supplement by the text authors, EXCEL® APPLICATIONS FOR ANALYTICAL CHEMISTRY, which integrates this important aspect of the study of analytical chemistry into the book's already rich pedagogy. New to this edition is OWL, an online homework and assessment tool that includes the Cengage YouBook, a fully customizable and interactive eBook, which enhances conceptual understanding through hands-on integrated multimedia interactivity.
Manual For Activities Directed At Underwater Cultural Heritage
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Author : Thijs J. Maarleveld
language : en
Publisher: UNESCO
Release Date : 2013
Manual For Activities Directed At Underwater Cultural Heritage written by Thijs J. Maarleveld and has been published by UNESCO this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Convention on the Protection of Underwater Cultural Heritage categories.
Host Bibliographic Record For Boundwith Item Barcode 30112044669122 And Others
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Author :
language : en
Publisher:
Release Date : 2013
Host Bibliographic Record For Boundwith Item Barcode 30112044669122 And Others written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Chinese Porcelain In Colonial Mexico
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Author : Meha Priyadarshini
language : en
Publisher: Springer
Release Date : 2018-01-14
Chinese Porcelain In Colonial Mexico written by Meha Priyadarshini and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-14 with History categories.
This book follows Chinese porcelain through the commodity chain, from its production in China to trade with Spanish Merchants in Manila, and to its eventual adoption by colonial society in Mexico. As trade connections increased in the early modern period, porcelain became an immensely popular and global product. This study focuses on one of the most exported objects, the guan. It shows how this porcelain jar was produced, made accessible across vast distances and how designs were borrowed and transformed into new creations within different artistic cultures. While people had increased access to global markets and products, this book argues that this new connectivity could engender more local outlooks and even heightened isolation in some places. It looks beyond the guan to the broader context of transpacific trade during this period, highlighting the importance and impact of Asian commodities in Spanish America.
Asylums
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Author : Erving Goffman
language : en
Publisher: Routledge
Release Date : 2017-09-08
Asylums written by Erving Goffman and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-08 with Social Science categories.
A total institution is defined by Goffman as a place of residence and work where a large number of like-situated, individuals, cut off from the wider society for an appreciable period of time, together lead an enclosed, formally administered round of life. Prisons serve as a clear example, providing we appreciate that what is prison-like about prisons is found in institutions whose members have broken no laws. This volume deals with total institutions in general and, mental hospitals, in particular. The main focus is, on the world of the inmate, not the world of the staff. A chief concern is to develop a sociological version of the structure of the self. Each of the essays in this book were intended to focus on the same issue--the inmate's situation in an institutional context. Each chapter approaches the central issue from a different vantage point, each introduction drawing upon a different source in sociology and having little direct relation to the other chapters. This method of presenting material may be irksome, but it allows the reader to pursue the main theme of each paper analytically and comparatively past the point that would be allowable in chapters of an integrated book. If sociological concepts are to be treated with affection, each must be traced back to where it best applies, followed from there wherever it seems to lead, and pressed to disclose the rest of its family.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Conjugate Divergent Margins
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Author : Webster Mohriak
language : en
Publisher: Geological Society of London
Release Date : 2013
Conjugate Divergent Margins written by Webster Mohriak and has been published by Geological Society of London this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Nature categories.
The main focus of the book is the geological and geophysical interpretation of sedimentary basins along the South, Central and North Atlantic conjugate margins, but concepts derived from physical models, outcrop analogues and present-day margins are also discussed in some chapters. There is an encompassing description of several conjugate margins worldwide, based on recent geophysical and geological datasets. An overview of important aspects related to the geodynamic development and petroleum geology of Atlantic-type sedimentary basins is also included. Several chapters analyse genetic mechanisms and break-up processes associated with rift-phase structures and salt tectonics, providing a full description of conjugate margin basins based on deep seismic profiles and potential field methods.--