Herpesvirus Latency
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Herpesvirus Latency
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Author : Benedikt B. Kaufer
language : en
Publisher: Frontiers Media SA
Release Date : 2020-09-14
Herpesvirus Latency written by Benedikt B. Kaufer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-14 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Latency Strategies Of Herpesviruses
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Author : Janos Minarovits
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-12-13
Latency Strategies Of Herpesviruses written by Janos Minarovits and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Medical categories.
This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.
The Conserved Biology Of Herpesvirus Latency
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Author : Aimee N. Reed
language : en
Publisher:
Release Date : 2014
The Conserved Biology Of Herpesvirus Latency written by Aimee N. Reed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Cyprinus categories.
Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish that survive KHV infection are latently infected lifelong carriers. Latency is a conserved mechanism among known herpesviruses and is under the control, in part, of viral gene and protein expression. Our previous study demonstrated that KHV becomes latent in peripheral white blood cells (WBC) of koi. In this study, KHV latency was further investigated in IgM WBC. The presence of the KHV genome in IgM WBC was about 20-fold more abundant than in IgM-WBC. To determine if KHV expressed genes during latency, transcription from all 8 open reading frames (ORFs) in the terminal repeat was investigated in IgM WBC from koi with latent KHV infection. Only a spliced ORF6 was found to be abundantly expressed in IgM+ WBC from KHV latently infected koi. The spliced ORF6 transcript was also detected in vitro during productive infection as early as 1 day post-infection. The ORF6 transcript from in vitro infection begins -127 bp upstream of the ATG and ends +188 bp downstream of the stop codon, +20 bp downstream of the polyadenylation signal. The hypothetical protein of ORF6 contains a consensus sequence with homology to a conserved domain of EBNA-3B and ICP4 from Epstein Barr virus and herpes simplex virus 1, respectively and both members of the Herpesviridae. This is the first report of latent KHV in B cells and identification of gene transcription during latency for a member of the Alloherpesviridae. To identify and collect an enriched population of KHV+ latently infected cells, a nanoflare probe was generated specific to ORF6 RNA and used to separate live KHV latently infected cells from total peripheral white blood cells. Using the nanoflare ORF6 probe, about 1% of peripheral WBC from latently infected koi were identified and collected by their expression of ORF6. When this enriched population of KHV+ latently infected cells was examined by RNA-seq, the ORF6 transcript was found to be the only viral transcript that consistently mapped to the KHV reference genome. This study demonstrated that a nanoflare RNA probe could be used to enrich latently infected cells, which can subsequently be used to characterize gene expression during KHV latency. Little is known about the molecular mechanisms and control of latency for KHV. In this study, the expression of viral protein from ORF6 mRNA was investigated by a polyclonal antibody specific to a synthetic peptide derived from predicted ORF6 protein (anti-ORF6). Using an immunofluorescence assay (IFA), positive staining to the anti-ORF6 was observed in both KHV-infected common carp brain (CCB) cells in vitro and IgM+ B cells from koi latently infected with KHV. No IFA staining was observed in uninfected CCB cells nor from IgM-B cells from KHV+ latently infected koi. The ORF6 protein expressed during productive infection was detected around 140 kDa, which is bigger than the ~80 kDa predicted protein. ORF6 protein at a similar size as the predicted protein was identified from cloned ORF6 protein in an expression vector pet6XHN transformed in E. coli. Based on an analysis using software GPS-SUMO, 5 potential sumoylation sites were identified in the ORF6 protein sequence. This study demonstrated that ORF6 protein is expressed during KHV latency in koi and may be sumoylated in infected cells. These works have unveiled molecular strategies of herpesvirus latency for KHV; the identification of a latency associated transcript as well as viral protein expression during latency, which demonstrate conserved mechanisms as other herpesvirus latency programs. Through these discoveries, it is possible to further investigate the conserved biology of herpesvirus latent infections by using the koi and KHV model for human herpesvirus associated diseases and therapies.
Molecular Aspects Of Turkey Herpesvirus Latency In Chickens
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Author : Margo Steele Holland
language : en
Publisher:
Release Date : 1994
Molecular Aspects Of Turkey Herpesvirus Latency In Chickens written by Margo Steele Holland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Chickens categories.
Human Herpesviruses
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Author : Ann Arvin
language : en
Publisher: Cambridge University Press
Release Date : 2007-08-16
Human Herpesviruses written by Ann Arvin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Latency Of Bovine Herpesvirus 1
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Author : Elisabeth Jane Homan
language : en
Publisher:
Release Date : 1980
Latency Of Bovine Herpesvirus 1 written by Elisabeth Jane Homan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Herpesviruses categories.
Latent Herpes Virus Infections In Veterinary Medicine
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Author : G. Wittmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Latent Herpes Virus Infections In Veterinary Medicine written by G. Wittmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This seminar referred to latent herpes virus infections in veterinary medicine, with emphasis on the domestic animals. The phenomenon of latency is of particular importance in veterinary medicine because it can jeopardize the successful control and eradication of diseases such as Aujeszky's disease and infectious bovine rhinotracheitis, diseases which are often the cause of great economic losses. For this reason, the Commission of the European Communities (CEC) realized the importance of summarizing the present state of knowledge on latent herpes virus infections in veterinary medicine. A seminar was therefore organized by the Federal Research Institute for Animal Virus Diseases in Ttibingen, Federal Republic of Germany, from September 21 to 23, 1982, as a part of the 'Animal Pathology Programme' of the CEC. The seminar was attended by 50 participants not only from the countries of the CEC, and 38 papers were selected for presentation. In veterinary medicine, more intensive investigations on the latency of animal herpes viruses have only relatively recently been initiated. In contrast, great efforts have been made for many years to elucidate latency in human and primate herpes viruses, and consequently the most considerable advances have been made in this field. Some of the most experienced scientists working on both systems were therefore invited. As a result, this seminar was the first occasion on which scientists from different countries and faculties investigating herpes virus latency had the opportunity to present and exchange their latest results. The.
Human Herpes Virus 8 New Insights For The Healthcare Professional 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-10
Human Herpes Virus 8 New Insights For The Healthcare Professional 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-10 with Medical categories.
Human Herpes Virus 8: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Human Herpes Virus 8 in a concise format. The editors have built Human Herpes Virus 8: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Human Herpes Virus 8 in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Human Herpes Virus 8: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
The Relationship Between Immune Competence And Latency With Marek S Disease Herpesvirus
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Author : Celina Buscaglia
language : en
Publisher:
Release Date : 1988
The Relationship Between Immune Competence And Latency With Marek S Disease Herpesvirus written by Celina Buscaglia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Immunocompetent cells categories.
Human Herpes Virus New Insights For The Healthcare Professional 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Human Herpes Virus New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Human Herpes Virus: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Human Herpes Virus in a compact format. The editors have built Human Herpes Virus: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Human Herpes Virus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Human Herpes Virus: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.