Hormesis

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Hormesis

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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-01

Hormesis written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Medical categories.

Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

The Science Of Hormesis In Health And Longevity

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Author : Suresh I. S. Rattan
language : en
Publisher: Academic Press
Release Date : 2018-10-23

The Science Of Hormesis In Health And Longevity written by Suresh I. S. Rattan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-23 with Medical categories.

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Hormesis In Health And Disease

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Author : Suresh I. S. Rattan
language : en
Publisher: CRC Press
Release Date : 2014-05-16

Hormesis In Health And Disease written by Suresh I. S. Rattan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-16 with Medical categories.

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.

Hormesis With Ionizing Radiation

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Author : T. D. Luckey
language : en
Publisher: CRC Press
Release Date : 2019-06-04

Hormesis With Ionizing Radiation written by T. D. Luckey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.

First published in 1980: The purpose of this Monograph, Hormesis With Ionizing Radiation, are to crystalize scattered information into an accepted subject of science and to awaken our society to new potential uses of ionizing radiation.

Hormesis

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Author : Mark Paul Mattson
language : en
Publisher:
Release Date : 2007

Hormesis written by Mark Paul Mattson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Low-level radiation categories.

Radiobiology And Radiation Hormesis

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Author : Charles L. Sanders
language : en
Publisher: Springer
Release Date : 2017-08-08

Radiobiology And Radiation Hormesis written by Charles L. Sanders and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-08 with Medical categories.

This book presents new information on radiobiology that more clearly refutes the linear no-threshold (LNT) assumption and supports radiation hormesis. Fresh light is cast on the mechanisms of radiation hormesis and the potential benefits of low-dose ionizing radiation in preventing and treating a wide variety of inflammatory and proliferative diseases. It is proposed that these effects may derive from cellular communication via electromagnetic waves directed by DNA, with each cell acting as a quantum computer. Readers will also find close analysis of the negative impacts of radiophobia on many aspects of modern life, including attitudes to imaging technologies, licensing of nuclear power reactors, and preparedness for survival of nuclear war. The book will be of interest to researchers and scientists in radiobiology, radiation protection, health physics, medical physics, and radiology. Specifically, it will provide medical physicians, radiation oncologists, radiation epidemiologists, gerontologists, cell biologists, toxicologists, and nuclear engineers with a wide range of interesting facts and enlightening novel perspectives.

Challenging Aging The Anti Senescence Effects Of Hormesis Environmental Enrichment And Information Exposure

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Author : Marios Kyriazis
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-08-30

Challenging Aging The Anti Senescence Effects Of Hormesis Environmental Enrichment And Information Exposure written by Marios Kyriazis and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-30 with Science categories.

Age-related degeneration may be reduced or even eliminated, by positively challenging the human being, physically or cognitively, to up-regulate somatic repair functions. Exposure to meaningful information and a challenging environment act as hormetic stressors which, in the context of an increasingly technological setting, may invoke evolutionary mechanisms that lead to a persistent maintenance of homeostasis. Thus, there is a strong link between environmental factors and ongoing health, leading to an individual’s ability to continually adapt to age related challenges. Challenging Ageing: The Anti-senescence Effects of Hormesis, Environmental Enrichment, and Information Exposure explains the role of hormesis in anti-aging processes followed by information on vitagenes, epigenetics, environmental enrichment and germlines. The monograph also brings newer concepts and theories to the fore, such as ‘environmental enrichment’ and ‘technoculture.’ Medical professionals and general readers, alike, will gain a a new perspective on the processes that counter aging processes in the human being.

Oxidative Stress And Hormesis In Evolutionary Ecology And Physiology

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Author : David Costantini
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-03-27

Oxidative Stress And Hormesis In Evolutionary Ecology And Physiology written by David Costantini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-27 with Science categories.

This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. In the first of ten chapters, general historical information, definitions, and background of research on oxidative stress physiology, hormesis, and life history are provided. Chapters 2-10 highlight the different solutions that organisms have evolved to cope with the oxidative threats posed by their environments and lifestyles. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms. The book offers fascinating insights into how organisms work and how they evolve to sustain their physiological functions under a vast array of environmental conditions.

Should Hormesis Be The Default Model In Risk Assessment

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Author : Edward J. Calabrese
language : en
Publisher: DIANE Publishing
Release Date : 2008-10

Should Hormesis Be The Default Model In Risk Assessment written by Edward J. Calabrese and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10 with Health & Fitness categories.

Hormesis

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Author : John Francois
language : en
Publisher:
Release Date : 2014

Hormesis written by John Francois and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Environmental toxicology categories.

The field of ecotoxicology has traditionally used monotonic relationships to study dose-responses, such as the linear, threshold or quadratic models. However, hormesis describes the dose-response relationship of toxicants as a biphasic curve, with low-dose stimulation, followed by high-dose inhibition. This phenomenon is hypothesized to be the result of an overcompensation response to a disturbance in homeostasis. In this manuscript, several aspects of hormesis were investigated. The first portion of this work tested the phenomenon itself with two anthropogenic toxicants (sulfosulfuron and glyphosate, growth-inhibiting herbicides) applied individually on the grass Bromus madritensis ssp. rubens. Numerous growth parameters and fitness indicators were measured to test whether a stimulatory effect in one parameter causes a tradeoff in a different parameter. Finally, the two toxicants were combined at individual hormetic doses to test whether hormesis is cumulative. Results support the hormesis hypothesis in all cases, with toxicants applied individually and in combination. In most experiments, there was no evidence of a tradeoff associated with the stimulation, but in one case, the stimulation was accompanied by a tradeoff in seed quality. The combination of toxicants at hormetic doses does not appear to be cumulative in terms of stimulation; however, the doses needed to achieve stimulation may be cumulative. In addition, different low doses caused stimulatory effects in different parameters, underlining the importance of parameter selection when studying hormesis. Finally, the timing of toxicant application can drastically alter hormetic responses. The second portion of this work tested the phenomenon using naturally-occurring toxicants. Two similar toxicants were used (caffeic acid and p-coumaric acid, both phenolic allelopathic chemicals), on two closely related grasses (Bromus madritensis ssp. rubens and Briza maxima). Both toxicants were applied to B. madritensis ssp. rubens to test whether similar toxicants generate comparable responses at similar doses. p-coumaric acid was also applied to B. maxima to test whether closely related grasses demonstrate a similar hormetic response at similar doses of a toxicant. Hormesis was detected in all three experiments. However, while the hormetic dose was comparable for both toxicants applied to B. madritensis ssp. rubens, the magnitude of stimulation was different. Conversely, the maximum stimulatory dose for both plants treated with p-coumaric acid differed considerably, while the stimulation itself was fairly consistent. In short, the data indicate that the hormetic concentration (but not the response) is generalizable across similar toxicants for a given species, and that the hormetic response (but not the concentration) is generalizable across similar species for a given toxicant. The final phase of this work attempted to elaborate a model system to study hormesis in plants. This system should be highly reproducible, and could be used to correlate stimulatory morphological effects to underlying molecular changes, namely gene expression profiles, and eventually protein expression as well. This may eventually lead to a mechanistic understanding of the hormesis phenomenon. Arabidopsis thaliana Col-0 was treated with imazapyr, a growth-inhibiting herbicide which targets the CSR1 subunit of AHAS, the first enzyme in the pathway for the biosynthesis of leucine, isoleucine and valine. Hormesis was successfully identified at a low dose of imazapyr. However, the stimulatory effect could not be reproduced in two subsequent repeats. Nonetheless, total RNA extractions were successfully performed on individual seedlings at various stages of growth to test whether sufficient RNA could be extracted from individual seedlings at all time points. Since hormesis is widely hypothesized to be an overcompensation response to a stressor agent, a logical starting place to assess the hormetic response in this system is to determine if the target of imazapyr is being upregulated when hormesis is present. Although live specimens from a hormetic treatment group were not harvested here, the primers designed to amplify the genes expressing the target enzyme, as well as reference genes, were successfully tested on non-hormetic specimens. If hormesis can be induced reproducibly in this system, the current methodology can effectively assess changes in gene expression. A more tightly controlled protocol, and the inclusion of more doses in the future, may increase the reproducibility of the hormetic phenomenon. The hormesis phenomenon has important implications for a number of fields. It has been suggested to play a role in ecological risk assessment, agriculture, pharmacology, medicine, pest management and others. As the number of examples of hormesis increases, and with a greater understanding of the phenomenon, the acceptance and usefulness of hormesis is likely to increase as well. Hence, while hormesis has often been overlooked, it is a topic which needs to be much more heavily investigated.