Humanized Mice
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Humanized Mice
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Author : Tatsuji Nomura
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-11
Humanized Mice written by Tatsuji Nomura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-11 with Medical categories.
The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.
Humanized Mice
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Author : Tatsuji Nomura
language : en
Publisher: Springer
Release Date : 2009-09-02
Humanized Mice written by Tatsuji Nomura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Medical categories.
The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.
Development Of Humanized Mouse Models For Infectious Diseases And Cancer
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Author : Moriya Tsuji
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-19
Development Of Humanized Mouse Models For Infectious Diseases And Cancer written by Moriya Tsuji and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-19 with categories.
Humanized Mice For Hiv Research
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Author : Larisa Y. Poluektova
language : en
Publisher: Springer
Release Date : 2015-02-18
Humanized Mice For Hiv Research written by Larisa Y. Poluektova and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-18 with Medical categories.
Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.
Humanized Mouse Models To Study Immune Responses To Human Infectious Organisms
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Author : Qingfeng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-28
Humanized Mouse Models To Study Immune Responses To Human Infectious Organisms written by Qingfeng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Medical categories.
A Novel Humanized Mouse Model For Evaluating Mechanisms Of Self Tolerance And Induced Pluripotent Stem Cell Immunogenicity
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Author : Matthew E. Brown
language : en
Publisher:
Release Date : 2016
A Novel Humanized Mouse Model For Evaluating Mechanisms Of Self Tolerance And Induced Pluripotent Stem Cell Immunogenicity written by Matthew E. Brown and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Two fundamental considerations in the development of effective regenerative medicine therapies are A) in vivo function of the therapy, and B) the patient-specific immune response to the therapy i.e. immunogenicity. As human pluripotent stem cell (PSC) differentiation protocols more reliably yield cells which accurately mimic primary cell function, PSC immunogenicity will increasingly be a key consideration for translation of these therapies to the clinic. This dissertation focuses on this second question of immunogenicity, specifically regarding a PSC type known as induced pluripotent stem cells (iPSCs). First, we examine the current research in the field and explore the use of humanized mouse models for regenerative medicine applications. Humanized mouse models allow us to experimentally test immunological hypotheses regarding PSC and other regenerative medicine therapies, and are very effective tools for evaluating pre-clinical therapies when combined with complementary in vitro assays of immunogenicity. Next, we detail the development of a novel humanized model, called the "NeoThy," which provides significant biological advantages for studies of human immune function, and bypasses certain ethical controversies associated with this area of research. The NeoThy incorporates neonatal thymus and cord blood tissues, which are much more abundant than the fetal sources currently used for conventional humanized mouse models. The use of non-fetal tissue allows for humanization of large numbers of NeoThy animals compared to fetal controls. This enables in-depth characterization of donor specimens and greater experimental consistency vs fetal tissue-based models. The NeoThy has equivalent human immune cell engraftment compared to fetal tissue humanized mice and exhibits T cell functionality in multiple assays. The dissertation next demonstrates reprogramming of iPSC lines from neonatal donors and creation of NeoThy mice to investigate the immune reaction to iPSC cell transplants. Lastly, we explore additional data related to humanized mice, PSC immunogenicity, and mechanisms of self-tolerance including Graft vs Host Disease, differential human cell engraftment in male vs female immune-deficient mice, thymic cellular composition and the impact of thymic developmental status on T cell development.
Humanized Mouse Models For Xenotolerance And Autoimmunity
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Author : Grace Ann Nauman
language : en
Publisher:
Release Date : 2019
Humanized Mouse Models For Xenotolerance And Autoimmunity written by Grace Ann Nauman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
APC reconstitution tends to be suboptimal in humanized mice and is even more so in mice transplanted with patient-derived CD34+ cells. Better characterization of human APC populations and their progenitors could allow us to develop approaches to improve long-term human APC reconstitution in patient-derived humanized mice, allowing us to more fully model patient peripheral T cell function.
Advances In Human Immune System His Mouse Models For Studying Human Hematopoiesis And Cancer Immunotherapy
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Author : Yasuyuki Saito
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10
Advances In Human Immune System His Mouse Models For Studying Human Hematopoiesis And Cancer Immunotherapy written by Yasuyuki Saito and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.
Topic Editor Prof. Aimin Xu receives financial support from Servier Laboratories. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
Humanized Mice For The Study Of Hiv Infection
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Author : Luca Baroncini
language : en
Publisher:
Release Date : 2023
Humanized Mice For The Study Of Hiv Infection written by Luca Baroncini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Humanized Mice As A Model To Study Human Viral Pathogenesis And Novel Antiviral Drugs
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Author : Freddy M. Sanchez
language : en
Publisher:
Release Date : 2012
Humanized Mice As A Model To Study Human Viral Pathogenesis And Novel Antiviral Drugs written by Freddy M. Sanchez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.