I M Studies

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Advancing Im Politeness Studies

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Author : Chaoqun Xie
language : en
Publisher: Springer Nature
Release Date : 2023-10-28

Advancing Im Politeness Studies written by Chaoqun Xie and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-28 with Language Arts & Disciplines categories.

This volume pushes forward research on (im)politeness by focusing on interpersonal interaction's cultural, digital and emotional aspects. With contributions by established and emerging scholars in the field, this collection explores and expounds, with the combination of solid theoretical foundation and up-close empirical demonstration, how (im)politeness not only gives but also gives off communicative and interpersonal meaning in diverse cultural contexts. Included are chapters on how (im)politeness contributes to the construction of social reality online and in social media and how (im)politeness prompts and is prompted by emotional sensitivities. This book is of interest and value to students and researchers in the field and those keen to know how effective human existence and essence are possible through the lens of (im)politeness.

International Journal Of Language Studies Ijls Volume 12 4

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Author : Mohammad Ali Salmani Nodoushan
language : en
Publisher: Lulu.com
Release Date :

International Journal Of Language Studies Ijls Volume 12 4 written by Mohammad Ali Salmani Nodoushan and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Social Im Mobilities In Africa

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Author : Joël Noret
language : en
Publisher: Berghahn Books
Release Date : 2019-11-08

Social Im Mobilities In Africa written by Joël Noret and has been published by Berghahn Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-08 with Social Science categories.

Grounded in both theory and ethnography, this volume insists on taking social positionality seriously when accounting for Africa’s current age of polarizing wealth. To this end, the book advocates a multidimensional view of African societies, in which social positions consist of a variety of intersecting social powers - or ‘capitals’ – including wealth, education, social relationships, religion, ethnicity, and others. Accordingly, the notion of social im/mobilities emphasizes the complexities of current changes, taking us beyond the prism of a one-dimensional social ladder, for social moves cannot always be apprehended through the binaries of ‘gains’ and ‘losses’.

The Philosophy Of Im Politeness

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Author : Chaoqun Xie
language : en
Publisher: Springer Nature
Release Date : 2021-12-14

The Philosophy Of Im Politeness written by Chaoqun Xie and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-14 with Language Arts & Disciplines categories.

This book explores what new light philosophical approaches shed on a deeper understanding of (im)politeness. There have been numerous studies on linguistic (im)politeness, however, little attention has been paid to its philosophical underpinnings. This book opens new avenues for both (im)politeness and philosophy. It contributes to a fruitful dialogue among philosophy, pragmatics, and sociology. This volume appeals to students and researchers in these fields.

Biobetters

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Author : Amy Rosenberg
language : en
Publisher: Springer
Release Date : 2015-08-21

Biobetters written by Amy Rosenberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Medical categories.

“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.

Library List

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Author : National Agricultural Library (U.S.)
language : en
Publisher:
Release Date : 1968

Library List written by National Agricultural Library (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Agriculture categories.

Studies

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Author : Rockefeller Institute for Medical Research
language : en
Publisher:
Release Date : 1911

Studies written by Rockefeller Institute for Medical Research and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1911 with Medicine categories.

Old And Middle English Language Studies

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Author :
language : en
Publisher: John Benjamins Publishing
Release Date : 1988-01-01

Old And Middle English Language Studies written by and has been published by John Benjamins Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Language Arts & Disciplines categories.

Since the publication of Kennedy's monumental Bibliography of Writings on the English Language, no bibliography has systematically surveyed the Old and Middle English scholarship accumulated over the past 60 years. Tajima's work aims to meet the need for an updated bibliography of Old and Middle English language studies; it lists books, monographs, dissertations, articles, notes, and reviews on Old and Middle English language. The items have been listed into fourteen fairly broad categories: (1) Bibliographies, (2) Dictionaries, glossaries and concordances, (3) Histories of the English language, (4) Grammars (historical, Old English and Middle English), (5) General and miscellaneous studies, (6) Language of individual authors or works, (7) Orthography and punctuation, (8) Phonology and phonetics, (9) Morphology, (10) Syntax, (11) Lexicology, lexicography and word-formation, (12) Onomastics, (13) Dialectology, (14) Stylistics.

First Generation College Student Research Studies

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Author : Terence Hicks
language : en
Publisher: Rowman & Littlefield
Release Date : 2019-07-15

First Generation College Student Research Studies written by Terence Hicks and has been published by Rowman & Littlefield this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-15 with Education categories.

First-Generation College Student Research Studies brings together research from a group of dynamic scholars from a variety of institutions across the United States. This extraordinary edited volume examines the first-generation college student population and analyzes topics such as college choice, social experiences, dual credit on academic success, lifestyles and health status, and professional identity/teaching practices. The empirical studies in this book contribute greatly to the research literature regarding the role that educational leaders have in educating first-generation college students.

Cscw

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Author :
language : en
Publisher:
Release Date : 2002

Cscw written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Microcomputer workstations categories.