Ige Receptor Fc Ri Function In Mast Cells And Basophils

DOWNLOAD

Download Ige Receptor Fc Ri Function In Mast Cells And Basophils PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Ige Receptor Fc Ri Function In Mast Cells And Basophils book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Ige Receptor Fc Ri Function In Mast Cells And Basophils

DOWNLOAD
Author : Majed M. Hamawy
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Ige Receptor Fc Ri Function In Mast Cells And Basophils written by Majed M. Hamawy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Ige Receptor Fceri Function In Mast Cells And Basophils

DOWNLOAD
Author : Majed M. Hamawy
language : en
Publisher:
Release Date : 1997-01-01

Ige Receptor Fceri Function In Mast Cells And Basophils written by Majed M. Hamawy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Fc receptors categories.

Mast Cells And Basophils

DOWNLOAD
Author : Gianni Marone
language : en
Publisher: Academic Press
Release Date : 2000-05-25

Mast Cells And Basophils written by Gianni Marone and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-25 with Medical categories.

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Ige Receptor Fceri Function In Mast Cells And Basophils

DOWNLOAD
Author : Majed M. Hamawy
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-01-01

Ige Receptor Fceri Function In Mast Cells And Basophils written by Majed M. Hamawy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Fc receptors categories.

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Ige Mast Cells And The Allergic Response

DOWNLOAD
Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30

Ige Mast Cells And The Allergic Response written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.

Reviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique in the IgE field for its breadth of coverage and interdisciplinary nature, and it shows the benefits from the current rapid expansion of knowledge in cell biology, immunology, and molecular genetics, as well as the potential clinical significance of this research to clinical immunologists and allergologists.

Immunopharmacology Of Mast Cells And Basophils

DOWNLOAD
Author : John C. Foreman
language : en
Publisher: Academic Press
Release Date : 1993-11-29

Immunopharmacology Of Mast Cells And Basophils written by John C. Foreman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-11-29 with Medical categories.

There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

Ige Antibody Dynamics And Its Role In Receptor Binding And Inhibition

DOWNLOAD
Author : Beomkyu Kim
language : en
Publisher:
Release Date : 2013

Ige Antibody Dynamics And Its Role In Receptor Binding And Inhibition written by Beomkyu Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.

IgE antibodies interact with the high affinity IgE Fc receptor (Fc [epsilon] RI) expressed on mast cells and basophils, and the low affinity IgE Fc receptor (CD23) on B cells. These interactions are directly involved in triggering the allergen-specific activation of inflammatory responses. The IgE-Fc region, comprising the C-terminal domains of the IgE heavy chain, binds Fc [epsilon] RI and the crystal structures of the human IgE-Fc alone and IgE-Fc complexes exhibited IgE-Fc conformational flexibility. In addition, the crystal structure of IgE-Fc bound to CD23 indicated a preference of CD23 for a closed conformation of the IgE-Fc incompatible with Fc [epsilon] RI binding. These observations suggested the importance of IgE conformational dynamics for its receptor binding mechanism and the potential to identify non-classical or allosteric inhibitors for IgE-receptor interactions. To investigate IgE dynamics and its role in receptor binding and inhibition, I have employed 5 experimental approaches: 1) IgE-Fc mutants trapped by an engineered disulfide bond, blocking Fc [epsilon] RI but not IgE inhibitor binding, 2) a fluorescence assay for IgE-Fc:Fc [epsilon] RI binding and inhibition that can distinguish IgE-inhibitors based on their proximity to the Fc [epsilon] RI binding site, 3) the determination of the E2_79 crystal structure showing that the IgE inhibitor E2_79 binds IgE-Fc outside the Fc [epsilon] RI-binding site and acts through a facilitated dissociation mechanism to block receptor binding, 4) the development of a TR-FRET assay suitable for high-throughput screening for small molecule inhibitors of IgE-receptor binding, and 5) a single-molecule FRET approach to characterize the conformational states of the IgE-Fc3-4 and observe changes upon Fc [epsilon] RI, CD23, and E2_79. These experiments revealed different conformational requirements for IgE binding, identified a disruptive inhibitor that actively dissociates preformed receptor complexes, and provided direct observation of receptor binding-induced IgE-Fc conformational changes. This work provides a new perspective on the role of IgE dynamics in receptor binding and inhibition, and makes possible the development of new disruptive inhibitors for IgE-receptor binding acting through non-classical or allosteric mechanisms.

Mast Cells And Basophils

DOWNLOAD
Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2006-01-04

Mast Cells And Basophils written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-04 with Medical categories.

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.

Signal Transduction In Mast Cells And Basophils

DOWNLOAD
Author : Ehud Razin
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-05-11

Signal Transduction In Mast Cells And Basophils written by Ehud Razin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-11 with Medical categories.

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.

Understanding Ige Receptor Signaling Through Computational Modeling And Quantitative Experiments

DOWNLOAD
Author : Lily Ann Chylek
language : en
Publisher:
Release Date : 2016

Understanding Ige Receptor Signaling Through Computational Modeling And Quantitative Experiments written by Lily Ann Chylek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Fc[epsilon]RI is a multi-subunit receptor found on the surface of mast cells and basophils and binds immunoglobulin E (IgE) with high affinity. Stimulation of this receptor, typically via antigen-mediated crosslinking of IgE, can lead to release of histamine and other mediators that are involved in the allergic immune response. Thus, understanding the workings of Fc[epsilon]RI-mediated signaling brings us closer to understanding one of the most widespread health conditions in the developed world. Fc[epsilon]RI-mediated signaling processes are inherently complex, involving highly interconnected systems in which quantitative factors can play a decisive role. Such systems can be difficult to decipher using intuition alone, but computational models can extend our reasoning abilities and enable us to develop nontrivial hypotheses that generate experimentally testable predictions. To develop a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated to impact cellular decisionmaking, we developed a computational interaction library. The library consists of executable rules for protein-protein and protein-lipid interactions. The library is visualized to facilitate understanding of network circuitry and identification of network motifs. Using this library, we investigated branching pathways from the adaptor protein Lat, which influence production of the phospholipid phosphatidylinositol (3,4,5)trisphosphate (PIP3) at the plasma membrane and the soluble second messenger inositol trisphosphate (IP3). We found that inclusion of a positive feedback loop gives rise to a bistable switch, which may ensure robust responses to stimulation above a threshold level. Such robustness has been observed experimentally for some readouts. We also developed a model that proposes an explanation for experimentally observed oscillations in Ca2+ concentration, which is an important outcome of Fc[epsilon]RI stimulation. To investigate Fc[epsilon]RI signaling from another angle, we modeled interactions between the receptor and a structurally defined ligand for IgE. We parameterized the model for consistency with kinetic fluorescence data as well as super-resolution imaging measurements of antigen-induced receptor aggregation. To facilitate this study, we developed a specialized tool for fitting biochemical models to experimental data. Finally, we examined how patterns of exposure to stimulatory and non-stimulatory ligands affect mast cells' secretory responses. Through iterative modeling and experimental tests, we learned that a tug-of-war between positive signals from the tyrosine kinase Syk and negative signals from the lipid phosphatase Ship-1 govern the magnitude of responses, with the adaptor protein Shc1 influencing how the balance of positive and negative signals changes with time.