Imaging Drug Action In The Brain
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Imaging Drug Action In The Brain
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Author : Edythe D. London
language : en
Publisher: Routledge
Release Date : 2017-11-22
Imaging Drug Action In The Brain written by Edythe D. London and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Medical categories.
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Imaging In Cns Drug Discovery And Development
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Author : David Borsook
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Imaging In Cns Drug Discovery And Development written by David Borsook and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Medical categories.
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Brain Imaging In Substance Abuse
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Author : Marc J. Kaufman
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-09-29
Brain Imaging In Substance Abuse written by Marc J. Kaufman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-29 with Medical categories.
The last two decades have seen prodigious growth in the application of brain imaging methods to questions of substance abuse and addiction. Despite considerable advances in our understanding of the central effects of drugs provided by preclinical data, relatively little direct evidence was known of how substances of abuse affect the brain and other eNS processes in humans. Brain imaging techniques have allowed access to the human brain and enabled the asking of questions never before imagined. The positron emission tomography (PET) data ofVolkow and her colleagues in the late 1980s, showing the uptake and time course of cocaine's binding in the human brain, revealed for the first time the distinct sites of action of this drug. This work was extremely important because it showed clearly, through imaging a drug in the brain of a living human, that the time course of its action paralleled the behavioral state of "high. " This study marked a turning point in our understanding of drug-brain-behav ior interactions in humans. Many more investigations of drug effects on the structure and function of the human brain were soon to follow, leading to much better insights into brain systems. Brain imaging allowed for the direct assessment of structural and functional anatomy, biology, and chemistry in substance abusers.
Sites Of Drug Action In The Human Brain
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Author : Anat Biegon
language : en
Publisher: CRC Press
Release Date : 2020-02-06
Sites Of Drug Action In The Human Brain written by Anat Biegon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-06 with Medical categories.
Sites of Drug Action in the Human Brain uses the results of recent analyses of the regional brain distribution and binding pattern of drugs in the human brain. This new book specifically addresses drugs of abuse and treats the effects of various drugs on behavior and mood, as well as on metabolism and blood flow in the human brain. It also presents the methodological aspects of investigating the sites of drug action in the human brain. Because it focuses on the living human brain, this book differs from other books on the subject, which primarily use the results of postmortem studies. Sites of Drug Action in the Human Brain therefore provides valuable information on the clinical aspects of drug intoxification, addiction, and toxicity.
Imaging Of The Human Brain In Health And Disease
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Author : Philip Seeman
language : en
Publisher: Elsevier
Release Date : 2013-11-15
Imaging Of The Human Brain In Health And Disease written by Philip Seeman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Science categories.
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
In Vivo Imaging In Pharmacological Research
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Author : Nicolau Beckmann
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-08
In Vivo Imaging In Pharmacological Research written by Nicolau Beckmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-08 with Electronic book categories.
The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.
Imaging Drug Action In The Brain
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Author : Edythe D. London
language : en
Publisher: Routledge
Release Date : 2017-11-22
Imaging Drug Action In The Brain written by Edythe D. London and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Medical categories.
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Neuroimaging Pharmacopoeia
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Author : Daniel Thomas Ginat
language : en
Publisher: Springer
Release Date : 2016-10-08
Neuroimaging Pharmacopoeia written by Daniel Thomas Ginat and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-08 with Medical categories.
This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.
Imaging In Drug Discovery And Early Clinical Trials
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Author : Markus Rudin
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25
Imaging In Drug Discovery And Early Clinical Trials written by Markus Rudin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.
This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.
Simultaneous Positron Emission Tomography Functional Magnetic Resonance Imaging For Imaging Neuroreceptor Dynamics
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Author : Christin Yen-Ming Sander
language : en
Publisher:
Release Date : 2014
Simultaneous Positron Emission Tomography Functional Magnetic Resonance Imaging For Imaging Neuroreceptor Dynamics written by Christin Yen-Ming Sander and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Whole-brain neuroimaging is a key technique for studying brain function and connectivity. Recent advances in combining two imaging modalities - magnetic resonance imaging (MRI) and positron emission tomography (PET) - into one integrated scanner, have created the opportunity to explore the underlying neurochemistry of brain function in more detail. Imaging these dynamics plays an important role for understanding drug action and function of neurochemical pathways in the brain and is crucial, yet largely unexplored, for creating and evaluating treatment of neurological and psychiatric disorders. In this thesis, we first address technological challenges in simultaneous PET/MRI by designing, building and evaluating PET compatible MR probes for brain imaging, which enable highly sensitive dual modality imaging. We then develop simultaneous imaging methods with PET and functional MRI to assess and validate relationships between receptor occupancy and changes in brain activity due to pharmacological challenges targeting the dopamine system. Our results indicate that dopamine receptor occupancies and vascular responses are correlated in anatomical space and with pharmacological dose. Moreover, the temporal dynamics of the signals show that a direct neurovascular coupling between receptor occupancy and hemodynamics exists and that a temporal divergence between PET and fMRI can be used to investigate previously unexplored neurochemical parameters and adaptation mechanisms in vivo. Overall, our findings provide insight into dopaminergic receptor dynamics and their effects on high-level brain function, paving a way to address receptor-specific brain dysfunction effectively.