Immunoglobulins
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The Immunoglobulins
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Author : Roald Nezlin
language : en
Publisher: Academic Press
Release Date : 1998-05-06
The Immunoglobulins written by Roald Nezlin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-06 with Science categories.
This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated
Immunoglobulins In Health And Disease
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Author : M. French
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunoglobulins In Health And Disease written by M. French and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Rapid advances continue to be made in all areas of immunology, not least the biology of the immunoglobulins. This knowledge has resulted in a better understanding of antibody responses and helped to clarify pathogenic mechanisms in many diseases, particularly autoimmune and allergic diseases, as well as expand our comprehension of antibody deficiency diseases and mechanisms in therapeutic immunization. In addition, the recognition that diverse disease states may result in abnormalities of the amount of immunoglobulins in body fluids has resulted in the use of immunoglobulin assays for disease diagnosis and management. The aim of this book has been to condense both the established and recent aspects of this knowledge, particularly that pertaining to clinical immunology. The contributions of different authors hopefully provide a comprehensive review of their particular field of interest as well as a discussion of how this information can be applied to clinical medicine. Immunological terms and concepts have been explained where appropriate so that the book can be read by those with only a basic knowledge of immunology. In producing a book on this one area of immunology some duplication of information has been accepted so that topics can be considered in different contexts. I hope the book will be of value to those in training or already pursuing a career in clinical or laboratory medicine by providing a basic and short text on immunoglobulins. M.A.H.F.
Immunoglobulins
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Author : Ezio Merler
language : en
Publisher:
Release Date : 1970
Immunoglobulins written by Ezio Merler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Medical categories.
Immunoglobulins
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Author : Gary W. Litman
language : en
Publisher: Springer
Release Date : 1978-10
Immunoglobulins written by Gary W. Litman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978-10 with Medical categories.
Since the discovery more than thirty years ago that antibody actlvlty could be localized to discrete plasma protein fractions, the study of immunoglobulin struc ture and function has dominated the field of immunochemistry. During this time, sources of homogeneous immunoglobulin molecules have been discovered, the subunit nature of the proteins has been defined, and the three-dimensional struc tures of the antigen-recognition portion of several antibody molecules have been elucidated. Insights into the complicated genetic control of these proteins are being gained rapidly through analysis of amino acid sequences of naturally occurring and induced homogeneous immunoglobulins. Immunoglobulins have been analyzed by protein chemists as models of complex multimeric systems, examined by geneticists studying serum protein polymorphisms, and employed by molecular biologists as highly selective probes capable of distinguishing minor features of molecular topog raphy. Clinical applications have ranged from the now routine quantitation of immunoglobulin levels to the use of antibodies to detect trace levels of a variety of natural products and drug metabolites. All these applications have depended ulti mately on a thorough understanding of the immunoglobulin and its antigen-combin ing site. To cover the entire field of immunoglobulin structure and function would require many volumes this size; therefore, subjects presented in this volume represent those which we felt contribute most to our current understanding of this protein family. The first chapters deal with the structure and function of the immunoglobulin molecule.
Cell Mediated Effects Of Immunoglobulins
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Author : Wolf H. Fridman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Mediated Effects Of Immunoglobulins written by Wolf H. Fridman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Interaction of antigen-antibody complexes with cells via specific immunoglobulin Fc receptors (FcR) triggers major immunological reactions such as efficient uptake of antigen, phagocytosis of microorganisms, cytotoxicity towards tumor or virus infected cells, mast cell degranulation and inflammation, etc. This book reviews the FcR for the different immunoglobulin isotypes, focusing on the structural bases of their biological functions, and on the regulation of their expression in physiology and pathology.
Immunoglobulins Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Immunoglobulins Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Immunoglobulins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Immunoglobulins. The editors have built Immunoglobulins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunoglobulins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Immunoglobulins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Immunoglobulins Cell Bound Receptors And Humoral Antibodies
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Author : Federation of European Biochemical Societies
language : en
Publisher:
Release Date : 1973
Immunoglobulins Cell Bound Receptors And Humoral Antibodies written by Federation of European Biochemical Societies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medical categories.
Discusses common plant families and airs such botanical scandals as the bar sinister of the Sumac family, the villainous daisy, the potato's poisonous relatives and others.
Immunoglobulins Magic Bullets And Therapeutic Antibodies
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Author : Manzoor Ahmad Mir
language : en
Publisher: Nova Science Publishers
Release Date : 2020-02-19
Immunoglobulins Magic Bullets And Therapeutic Antibodies written by Manzoor Ahmad Mir and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-19 with Medical categories.
The book "Immunoglobulins, Magic Bullets and Therapeutic Antibodies" comprises of ten chapters and it describes the origin, history, timeline, production and scope of immunoglobulins which are the central molecules of the immune system around which the field of immunology revolves. This book describes how the immune system responds to injuries and insults by foreign antigens (bacteria, viruses etc) and produces immunoglobulins, which then through various immune response mechanisms protect the body against pathogenic invasions. Further, it discusses how these antigens are involved in the differentiation and maturation of immune cells, how lymph nodes are involved in concentrating the antigens, how immunogenicity of an antigen is affected and how antigenicity of immunogens is related to the immune response. Classification of immunoglobulins and the organization and expression of immunoglobulin genes is described separately. The antigen antibody interactions and antibody dependent cell mediated cytotoxicity are also discussed in separate chapters. The magic bullets or monoclonal antibodies, which have revolutionized the field of immunology, are described in greater detail, their production by hybridoma technology and the important role played by these antibodies in research, diagnostics and therapeutics is also discussed in the book. Lastly the immunodiagnostic techniques like radioimmunoassay (RIA), Enzyme Linked Immunosorbent Assay (ELISA), flowcytometry and their importance in the detection of various kinds of diseases like cancer, HIV-AIDS, tuberculosis, malaria, etc. are discussed in detail as well in the book. The book contains a large number of flow charts, diagrams, depictions and tables highlighting the properties, characteristic features, functions and roles played by these immunoglobulins in various fields of biosciences.
The Genetic Markers Of Human Immunoglobulins
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Author : Rune E. Grubb
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Genetic Markers Of Human Immunoglobulins written by Rune E. Grubb and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema leading to suffocation and death from anaphylaxis. An approach to the understanding of immunoglobulin polymorphism based upon "a knowledge of genetic markers of immunoglobulin structure is not biased by the question of whether or not this polymorphism is related to combining site diversity. Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources. Several of the human genetic im~unoglobulin markers are well understood at the molecular level. The Gm system may serv~ as a model for other immuno genetic systems. The published data on the human immunoglobulin factors are widely scattered in journals of different perspectives. There is a need for a systematic presentation of these data and for their critical evaluation.
Maternofoetal Transmission Of Immunoglobulins
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Author : W. A. Hemmings
language : en
Publisher: CUP Archive
Release Date : 1976-03-25
Maternofoetal Transmission Of Immunoglobulins written by W. A. Hemmings and has been published by CUP Archive this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976-03-25 with Health & Fitness categories.