Immunologic Approaches For The Treatment Of Lymphoid Malignancies
DOWNLOAD
Download Immunologic Approaches For The Treatment Of Lymphoid Malignancies PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Immunologic Approaches For The Treatment Of Lymphoid Malignancies book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Precision Cancer Therapies Volume 2 Immunologic Approaches For The Treatment Of Lymphoid Malignancies
DOWNLOAD
Author : Owen A. O'Connor
language : en
Publisher: John Wiley & Sons
Release Date : 2024-04-29
Precision Cancer Therapies Volume 2 Immunologic Approaches For The Treatment Of Lymphoid Malignancies written by Owen A. O'Connor and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-29 with Medical categories.
Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.
Immunologic Approaches For The Treatment Of Lymphoid Malignancies
DOWNLOAD
Author : Owen A. O'Connor
language : en
Publisher: Wiley-Blackwell
Release Date : 2024-02
Immunologic Approaches For The Treatment Of Lymphoid Malignancies written by Owen A. O'Connor and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02 with Medical categories.
Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.
Immunologic Approaches To The Classification And Management Of Lymphomas And Leukemias
DOWNLOAD
Author : John M. Bennett
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunologic Approaches To The Classification And Management Of Lymphomas And Leukemias written by John M. Bennett and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general on cology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Therapeutic Strategies In Lymphoid Malignancy
DOWNLOAD
Author : P. Hillmen
language : en
Publisher: CRC Press
Release Date : 2005-08-15
Therapeutic Strategies In Lymphoid Malignancy written by P. Hillmen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-15 with Medical categories.
Targeted therapies are the focus of much research in oncology. Encouraging results from the development of new monoclonal antibodies are revolutionizing clinical therapies and this is particularly the case for haematologic malignancies. The advent of immunotherapy heralds a new era particularly for patients who are refractory to more traditional therapies. Impressive results are evident using monoclonal antibodies (mAb) that a) bind with high specificity to cell-surface antigens, resulting in targeted killing of the malignant cells or b) are conjugated to radioisotopes, toxins, enzymes or drugs that have the potential to reach high concentration at the tumour site. Not only do these agents improve remission and overall survival, but also many new studies have shown that they can be even more effective when used in combination with more traditional therapies. This unique book brings together a series of topical discussions of how the new immunotherapeutic agents can be used successfully to treat lymphoid malignancies. The contributors are prestigious clinicians and researchers working at the cutting edge of the field. This will be an invaluable resource for the haematologist or oncologist who will find up-to-date data and clinical advice regarding the latest immunotherapeutic options in haematology.
Follicular Lymphoma
DOWNLOAD
Author : Nathan H. Fowler
language : en
Publisher: Springer Nature
Release Date : 2019-12-02
Follicular Lymphoma written by Nathan H. Fowler and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-02 with Medical categories.
This book provides a comprehensive, state-of-the-art overview of follicular lymphoma. The first section of the text explores the current understanding of the biology and pathogenesis of follicular lymphoma, through reviewing recent changes in the WHO classification of low-grade lymphomas, current diagnostic techniques, and emerging research on the importance of the immune microenvironment. The second section focuses on current treatment for localized disease, advanced stage disease, and transformed follicular lymphomas, and details currently FDA approved regimens and evolving radiation techniques for early stage and advanced disease. The last section of the text presents emerging approaches in targeted, immunologic, and vaccine therapy. Written by experts in the field, Follicular Lymphoma: Current Management and Novel Approaches is a valuable resource for practicing clinicians, practitioners, and researchers who manage and have an interest in follicular lymphoma.
Non Hodgkin Lymphomas
DOWNLOAD
Author : James O. Armitage
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2009-11-01
Non Hodgkin Lymphomas written by James O. Armitage and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-01 with Medical categories.
Thoroughly updated for its Second Edition, Non-Hodgkin Lymphomas is the definitive textbook on the biology, diagnosis, staging, and treatment of all forms of non-Hodgkin lymphomas. With backgrounds in medical and radiation oncology, molecular biology, and pathology, the editors and contributors provide an international, multidisciplinary approach to the topic. This edition is the first text using the new World Health Organization classification of non-Hodgkin lymphomas. The book offers complete coverage of the most current techniques for diagnosis, staging, and treatment, the approach to specific types of lymphoma, and special problems common to the management of patients with these disorders. A companion Website includes the fully searchable text and downloadable images.
Malignant Lymphomas And Hodgkin S Disease Experimental And Therapeutic Advances
DOWNLOAD
Author : Franco Cavalli
language : en
Publisher: Springer
Release Date : 1986-01-31
Malignant Lymphomas And Hodgkin S Disease Experimental And Therapeutic Advances written by Franco Cavalli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-01-31 with Medical categories.
Malignant lymphomas remain a fascinating research topic for clinicians as well as basic scientists. Rapidly increasing technical sophistication, ex panded knowledge and broader implications of new findings underline the need for a forum to integrate the latest developments in the multiple areas involved in the challenging study of lymphoid malignancies. This volume includes contributions of renowned experts and is based on a selection of papers presented at the Second International Conference on Malignant Lymphomas that was held in Lugano, Switzerland, in June 1984. Updated information is provided on various experimental fields including cell biolo gy, immunology, genetics and cell biochemistry. Particular attention has been given to special clinical entities such as the lymphomas associated with the Acquired Immune Deficiency Syndrome. Recent advances in the treat of Hodgkin's disease, ncin-Hodgkin's lymphomas and childhood lym ment phomas are highlighted with emphasis on growing experience with new therapeutic approaches including monoclonal antibodies and bone marrow transplantation. The contents of the volume reflect and translate numerous avenues of exploration. While there might be some unavoidable overlap, most appear essentially complementary. The intent of the Program Committee of the Second International Conference on Malignant Lymphomas was to promote further interactions between all those who are devoting major efforts to elucidate the nature of these diseases or their optimal therapy. This volume will hopefully amplify this objective. The Editors wish to thank the contributors for delivering the manuscripts on schedule.
Essential Oncology Of The Lymphocyte
DOWNLOAD
Author : Ian J. Forbes
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Essential Oncology Of The Lymphocyte written by Ian J. Forbes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book has been written from two points of view: firstly, from the viewpoint of those who are involved in the diagnosis and treatment of lymphoid malignancies, who must meet the challenge of integrating the new biological insights into their knowledge of these diseases; and secondly, from the viewpoint of those who are involved in basic biological approaches to malignancy and immunology, who wish to know more about the function of the lymphoid tissues and their malignant diseases. Neoplasia of lymphocytes is a focus for considering many of the most important biological advances impinging on cancer in the past two or three decades, because malignant lymphoproliferative diseases offer unequalled opportunities for studying many aspects of cancer. We probably know more about lymphocytes than other normal cells because of the ease with which they can be obtained. For the same reason we probably know more about malignant lymphocytes. One or other aspect of most of the momentous advances in biology of the past two or three decades has implications for lymphoid malignancies: hybridoma technology and the use of monoclonal antibodies, gene technology, the understanding of oncogenes and growth factors in the control of growth and differentiation, insights into causation of cancer by potent tumour promoters such as the phorbol esters and by viruses, and knowledge of the control of growth function of lymphocytes themselves. Conversely, many of the advances in understanding lym phocytic leukaemias and lymphomas have implications for other cancers.
Novel Immunotherapeutic Approaches To The Treatment Of Cancer
DOWNLOAD
Author : Paul D. Rennert
language : en
Publisher: Springer
Release Date : 2016-05-30
Novel Immunotherapeutic Approaches To The Treatment Of Cancer written by Paul D. Rennert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-30 with Medical categories.
Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Human Malignancies
DOWNLOAD
Author : D. Drahovsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Malignancies written by D. Drahovsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
To scientists, oncology means research on the disease of cancer. The connection between basic research and clinical oncology, however, is not always very clear. Basic research sometimes appears to be an art that is practiced for its own sake and admired for its perfection. The clinician wishes to interpret the issues addressed by basic research, as he is eager to obtain answers to the questions that clinical oncology leaves open. These are, among others, questions as to the etiology and pathogenesis of neoplasma in human beings. In spite of all the technological advances during the past 10 years, the guidelines for new treatments of human leukemias and tumors are still unsatisfactory. The dialogue between researchers and clinicians must never cease, so that these questions can be formulated in such a way that science may be able to answer them. Both parties should cooperate whenever this is useful and possible. Prospectively planned clinical trials on the diagnosis and therapy of neoplasias offer a good opportunity for research involving patients. Tumor and/or blood tests run by reference laboratories on a great number of patients with the same diagnosis can lead to clinically relevant basic research. Using clinical studies in basic research programs permits us to trace missing pieces in the puzzle of cancer and put them into place.