Immunotherapy In Asthma
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Immunotherapy In Asthma
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Author : Jean Bousquet
language : en
Publisher: CRC Press
Release Date : 1999-08-24
Immunotherapy In Asthma written by Jean Bousquet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-24 with Medical categories.
This massive reference thoroughly analyzes the mechanisms implicated in the pathophysiology of asthma, such as T helper lymphocyte subsets, and the consequences of various extrinsic and intrinsic factors, and IgE receptor expression-reviewing current concepts in immunotherapeutic approaches for the treatment of this and other allergic diseases. Investigates the only category of treatment showing the potential to affect the natural course of allergic diseases and prevent the onset of asthma. Written by more than 80 internationally renowned pulmonary experts, allergic disease specialists, and basic researchers, Immunotherapy in Asthma discusses the efficacy of new medications examines the role of metachromatic cells, lymphocytes, macrophages, and other cell types present in bronchial biopsies presents basic topics such as the functional and phenotypic properties of Th1 and Th2 cells and their role in allergic disease and the regulation of IgE-mediated inflammatory responses addresses the deleterious effects of smoking and passive exposure to cigarette smoke in children and adults assesses differences and similarities between intrinsic and antigen-induced asthma describes the effects of immunogenic peptides on the cytokine production profile of allergen-specific CD4+ T cells explains the different clinical aspects of allergic responses, such as bronchial hyperreactivity and eosinophilic inflammation of the airways reviews the genetic basis of allergy, as well as risk factors for asthma explores oral, sublingual, local nasal, and local bronchial routes for noninjective immunotherapies evaluates various agents with modulatory effects on normal and pathogenic immune responses focuses on strategies for the prevention of childhood asthma and more! Containing over 3000 references, drawings, and tables, Immunotherapy in Asthma is an indispensable resource for pulmonologists, immunologists, allergists, and medical school students in these disciplines.
Immunotherapies For Allergic Disease
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Author : Linda S. Cox
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-11-19
Immunotherapies For Allergic Disease written by Linda S. Cox and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-19 with Medical categories.
Get a quick, expert overview of the use of current and novel immunotherapies for use in the management and treatment of allergic reactions and diseases. This concise resource by Dr. Linda Cox covers the full range of allergic disease, including aeroallergens, asthma, food allergies, atopic dermatitis, and stinging insects. With essential coverage of allergen immunotherapies in addition to key topics on emerging allergen-associated immunomodulators, this succinct, comprehensive reference consolidates today’s available information on this timely topic into a single convenient resource. Discusses timely topics such as food tolerance, allergy, and allergen unresponsiveness; biologics for COPD and pediatric asthma; and adherence and pharmacoeconomics. Summarizes practical guidelines and recommendations for use of immunotherapies in clinical practice. Provides insight into the background and history of immunotherapies as a treatment for allergic disease. Includes developments on the horizon, including alternative immunotherapy routes and modified allergens.
Allergy And Allergen Immunotherapy
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Author : A.B. Singh
language : en
Publisher: CRC Press
Release Date : 2017-03-16
Allergy And Allergen Immunotherapy written by A.B. Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-16 with Medical categories.
Allergy and Allergen Immunotherapy: New Mechanisms and Strategies is a valuable and comprehensive book that covers allergy and causative allergens and provides diagnostic and therapeutic aspects as well. With chapters from internationally recognized experts in the field, the book provides a balanced approach to enumerating pollen allergens as well as allergy diagnosis and therapeutic management and safety assessment of genetically engineered food allergens. The book features a special section on allergic diseases and allergens from tropical countries, including such countries such as India, Sri Lanka, Iran, and South Korea, giving the book a global appeal. The book is broken in the following sections: Epidemiology, Pathophysiology, and Diagnosis of Allergy Aerobiology and Allergic Diseases Pollen Allergy in the Tropics and Temperate Regions Allergy in Children Food Allergy Evaluation Allergen Immunotherapy and Anti IgE The book deals not only on basics of allergy and allergen immunotherapy but also discusses indoor environments and safety considerations of genetically modified food allergens. The first of its kind volume from the Indian subcontinent that caters to the needs of clinicians, aerobiologists, environmentalists, and regulatory agencies as well, the volume will be of immense interest for clinicians and patients of allergy as well as diagnostic and therapeutic management of allergy in tropics.
Allergen Specific Immunotherapy For The Treatment Of Allergic Rhinoconjunctivitis And Or Asthma Comparative Effectiveness Review
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Author : U. S. Department of Health and Human Services
language : en
Publisher: Createspace Independent Pub
Release Date : 2013-05-20
Allergen Specific Immunotherapy For The Treatment Of Allergic Rhinoconjunctivitis And Or Asthma Comparative Effectiveness Review written by U. S. Department of Health and Human Services and has been published by Createspace Independent Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-20 with Medical categories.
Allergic rhinitis is a widespread clinical problem, estimated to affect 20 to 40 percent of the population in the U.S. Inhalant allergens, such as plant pollens, characteristically cause seasonal rhinoconjunctivitis and/or asthma; whereas, cat dander, cockroaches, or dust mite allergens may induce symptoms year-round, and are associated with perennial rhinitis and/or asthma. The prevalence of asthma in the U.S. is approximately 9 percent, and approximately 62 percent of individuals with asthma show evidence of also having atopy (i.e., one or more positive-specific IgE levels). The medical management of patients with allergic rhinitis and asthma includes allergen avoidance, pharmacotherapy, and immunotherapy. Allergen-specific immunotherapy (SIT) is typically recommended for patients whose allergic rhinoconjunctivitis and asthma symptoms cannot be controlled by medication and environmental controls, for patients who cannot tolerate medications, or for patients who do not comply with chronic medication regimens. Currently, two forms of specific immunotherapy are used clinically in the U.S. The U.S. Food and Drug Administration (FDA) has approved the use of allergen extracts for subcutaneous administration (subcutaneous immunotherapy) for the treatment of seasonal and perennial allergic rhinitis and allergic asthma. In the U.S., a patient with allergies receives subcutaneous injections of an allergen-containing extract, comprised of the relevant allergens to which the patient is sensitive, in increasing doses, in an attempt to suppress or eliminate allergic symptomatology. Considerable interest has also evolved in using sublingual immunotherapy as an alternative to subcutaneous injection immunotherapy. Sublingual immunotherapy involves placement of the allergen under the tongue for local absorption to desensitize the allergic individual over a period of months to years and diminish allergic symptoms. In 1996, an Immunotherapy Task Force, assembled by the World Allergy Organization, cited the emerging clinical data on sublingual immunotherapy, recognized its potential as a viable alternative to subcutaneous therapy, and encouraged continued clinical investigation to characterize optimal techniques. Over the past two decades, sublingual forms of immunotherapy have gained favor in Europe; sublingual tablet immunotherapy has been approved by the European regulatory authorities. In the U.S., there are currently no FDA-approved sublingual forms of immunotherapy. In the absence of FDA-approved sublingual forms of immunotherapy, some researchers and physicians in the U.S. are exploring the off-label use of subcutaneous aqueous allergens for sublingual desensitization. An increasing number of U.S. physicians are employing this alternate desensitization approach in the treatment of allergic respiratory conditions based on European and U.S. studies, and on the European Medicines Agency's approval of certain oral products; however, due to differing standardization of potency in Europe and the United States, doses have been hard to translate between countries. The primary objective of this comparative effectiveness review is to evaluate the efficacy, effectiveness, and safety of SIT (including both subcutaneous and sublingual immunotherapy) that are presently available for use by clinicians and patients in the U.S. We addressed the following Key Questions (KQs): KQ1. What is the evidence for the efficacy and effectiveness of SIT in the treatment of allergic rhinoconjunctivitis and/or asthma? KQ2. What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or asthma? KQ3. Is the safety and effectiveness of SIT different in distinct subpopulations with allergic rhinoconjunctivitis and/or asthma? Specifically: Children, Adults, Elderly, Pregnant women, Minorities, Inner-city and rural residents, Monosensitized individuals, Patients with severe asthma.
Proceedings Of The Immunotherapy In Allergic Asthma Consensus Conference
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Author : Immunotherapy in Allergic Asthma Consensus Conference (2000, New York, NY)
language : en
Publisher:
Release Date : 2001
Proceedings Of The Immunotherapy In Allergic Asthma Consensus Conference written by Immunotherapy in Allergic Asthma Consensus Conference (2000, New York, NY) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Asthma
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Author : Friedrich Kummer
language : de
Publisher: Springer
Release Date : 1993-07-08
Asthma written by Friedrich Kummer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-07-08 with Medical categories.
Das Konzept des allergischen Asthma hat lange Zeit so sehr dominiert, daß die Immunotherapie vielfach ohne gesicherte diagnostische Grundlage, halbherzig oder ohne die Feinheiten der Allergenvermeidung angewendet wurde. Die Forschung der letzten zehn Jahre hat uns eine derartige Ausweitung unseres Wissenshorizontes beschert, daß es an der Zeit schien, maßgebliche Autoren zur gemeinsamen Diskussion der neuen Aspekte einzuladen. Das Buch berichtet von den neuesten Erkenntnissen über zelluläres Verhalten, unterschiedliche Zytokinmuster und autoimmunologische Aspekte bis hin zur modernen Allergenvermeidung, aber auch von der wirksamen medikamentösen Therapie der eosinophilen EntzündungThe concept of asthma being an "allergic disorder only" has dominated above others to an extent, that a re-evaluation of this issue in the light of very recent results from research in immunopathology seemed more than overdue.This volume provides a current concept of theory and clinical practice of immunopathology and therapy of asthma, comprising extensive and brand new laboratory data on atopy, intrinsic asthma, aspects of autoimmunology, as well as guidelines for allergen avoidance, immunotherapy and - last not least - pharmacological treatment of eosinophilic inflammation.
Allergens And Allergen Immunotherapy
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Author : Richard F. Lockey
language : en
Publisher: CRC Press
Release Date : 2014-02-19
Allergens And Allergen Immunotherapy written by Richard F. Lockey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-19 with Medical categories.
This fifth edition of the bestselling Allergens and Allergen Immunotherapy is now completely updated and revised to include subcutaneous, sublingual, and oral immunomodulator treatments of allergic disease. The redesigned book continues to provide comprehensive coverage of all types of allergens and allergen vaccines, giving clinicians the essential information they need to accurately make a diagnosis and offer the best possible treatments. The fifth edition contains many new and revised chapters—particularly in the fields of skin testing—and extensive updates to the sublingual and oral immunotherapy chapters. Key Features: Comprehensive – covers a vast range of allergens and allergen immunotherapies, providing all the necessary information in one volume Synoptic – supplies the essential information using figures and tables for instant access Up-to-date – includes the very latest information on subcutaneous, sublingual and oral allergen immunotherapies to offer the best possible treatments Reliable – provides basic information that all clinicians need to know about cross-reactivity among allergens and how it influences diagnosis and treatment, as well as the key information necessary to carry out any form of immunotherapy in a safe and effective manner Supplemental forms – contains template forms that can be used by the clinician in daily practice The fifth edition of this classic text continues to be an essential touchstone for any practitioner who conducts skin tests and prescribes subcutaneous, sublingual, and oral immunotherapies.
Allergen Specific Immunotherapy For The Treatment Of Allergic Rhinoconjunctivitis And Or Asthma
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Author : Sandra Y. Lin
language : en
Publisher:
Release Date : 2013
Allergen Specific Immunotherapy For The Treatment Of Allergic Rhinoconjunctivitis And Or Asthma written by Sandra Y. Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
OBJECTIVES: Allergic rhinitis is highly prevalent in North America, affecting 20 to 40 percent of the population. Nearly 9 percent of Americans suffer from asthma, with more than half having evidence of atopy. This comparative effectiveness review describes the effectiveness and safety of subcutaneous immunotherapy and sublingual immunotherapy (off-label use of subcutaneous-aqueous allergens for sublingual desensitization) compared with other therapies for treatment of allergic rhinoconjunctivitis and asthma. DATA SOURCES: We searched the MEDLINE(r), Embase, LILACS, and CENTRAL databases from the beginning of each database through May 21, 2012. REVIEW METHODS: Two reviewers independently selected randomized controlled trials according to established study inclusion criteria. Disagreements were resolved by consensus. Paired reviewers assessed the risk of bias of each study and extracted details about the population, intervention(s), and outcomes of interest. The results were summarized by immunotherapy type (sublingual or subcutaneous), allergen, and outcomes. Studies exclusively enrolling children were reviewed separately. The strength of the body of evidence was graded and summarized. RESULTS: We included 74 references that investigated the efficacy and safety of subcutaneous immunotherapy, 60 studies that investigated the efficacy and safety of sublingual immunotherapy, and 8 studies that compared the two modes of delivery. All 142 studies were randomized controlled studies. The majority of studies were at medium risk of bias due to design choices. The strength of evidence is high that subcutaneous immunotherapy reduces asthma symptoms, rhinitis symptoms, conjunctivitis symptoms, asthma medication use, asthma plus rhinoconjunctivitis medication use, and rhinoconjunctivitis-specific quality of life. The strength of evidence is moderate that subcutaneous immunotherapy reduces rhinoconjunctivitis medication use, relative to usual care, which includes pharmacotherapy. Likewise, the strength of evidence is high that sublingual immunotherapy reduces asthma symptoms. The strength of evidence is moderate that sublingual immunotherapy reduces rhinitis/rhinoconjunctivitis symptoms, combined symptom scores, conjunctivitis symptoms, and medication useusage relative to usual care, and improves allergy-specific quality of life. In studies comparing subcutaneous with sublingual immunotherapy, strength of evidence supporting the superiority of subcutaneous immunotherapy for reducing allergic rhinitis and conjunctivitis symptoms, and the superiority of sublingual immunotherapy for reducing medication use, is low. We identified 13 pediatric studies of subcutaneous immunotherapy, 18 pediatric studies of sublingual immunotherapy, and 3 pediatric studies comparing subcutaneous and sublingual immunotherapy. The strength of evidence is moderate that subcutaneous immunotherapy reduces asthma symptoms and rhinitis symptoms in comparison to usual care. The strength of evidence is low that subcutaneous immunotherapy reduces conjunctivitis symptoms, medication scores, combined symptom-medication scores, or improves quality of life relative to usual care. The strength of evidence is high that sublingual immunotherapy reduces asthma symptoms, and moderate that it reduces rhinitis/rhinoconjunctivitis symptoms, combined asthma plus rhinitis/rhinoconjunctivitis symptoms, conjunctivitis symptoms, and decreases medication use. While local reactions were frequent with both treatment regimens, there were rare reports of anaphylaxis in the subcutaneous immunotherapy studies, and no anaphylaxis reported in the sublingual immunotherapy studies. CONCLUSIONS: With some variation across outcomes, the overall body of evidence consistently provides moderate to high support for the effectiveness and safety of both subcutaneous and sublingual immunotherapy for the treatment of allergic rhinitis and asthma. The evidence to support the use of immunotherapy in children is somewhat weaker than the evidence supporting its use in adults. The superiority of one route of administration over the other is not known.
The Role Of Immunotherapy In The Treatment Of Asthma
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Author : Sandra Y. Lin
language : en
Publisher:
Release Date : 2018
The Role Of Immunotherapy In The Treatment Of Asthma written by Sandra Y. Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
OBJECTIVES: To evaluate the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in the treatment of allergic asthma. DATA SOURCES: We searched PubMed, Embase, and CENTRAL through May 8, 2017. METHODS: Two reviewers independently selected randomized controlled trials (RCTs) of the efficacy of SCIT and SLIT and RCTs, observational studies, and case series or case reports on safety. Two reviewers independently assessed the risk of bias for each study and together graded the strength of the evidence. RESULTS: We identified 54 RCTs on efficacy: 31 assessed SCIT and 18 assessed SLIT and 5 on SCIT versus SLIT. We included 80 studies on safety: 26 RCTs and 18 non-RCTs for SCIT, 20 RCTs and 10 non-RCTs for SLIT and one non-RCT on SCIT versus SLIT. SCIT reduces the use of long-term control medications [moderate strength of evidence (SOE)]. SCIT may improve quality of life, reduce the use of quick-relief medications (short-acting bronchodilators), reduce the need for systemic corticosteroids, and improve FEV1 (low SOE). There was insufficient evidence regarding the effect of SCIT on asthma symptoms and health care utilization. Local and systemic allergic reactions were frequent but infrequently required a change in treatment. We are unable to draw conclusions about whether SCIT increased risk of anaphylaxis, primarily because anaphylaxis was not directly measured (insufficient SOE). There was one case report of a death determined possibly to be caused by SCIT. SLIT improves asthma symptoms (high SOE); decreases use of long-term control medication and improves FEV1 (moderate SOE). SLIT may decrease quick-relief medication use, and may improve quality of life (low SOE). There was insufficient evidence about the effect of SLIT on systemic corticosteroid use and health care utilization. Local and systemic allergic reactions were common but infrequently required changes in treatment. Life-threatening reactions were not commonly reported, with three case reports of anaphylaxis (insufficient SOE) and no deaths (moderate SOE) reported. There was insufficient evidence to draw conclusions about the comparative effects of SCIT versus SLIT or for differential effects of immunotherapy based on patient age, setting of administration, or type of allergen. CONCLUSIONS: Overall, SLIT and SCIT were beneficial for the majority of asthma-related outcomes assessed in this report. Local and systemic allergic reactions were common but infrequently required changes in treatment. Life-threatening events (such as anaphylaxis) were reported rarely.
Immunotherapy In A Murine Model Of Allergic Asthma
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Author : Edith Margarethe Janssen
language : en
Publisher:
Release Date : 1999
Immunotherapy In A Murine Model Of Allergic Asthma written by Edith Margarethe Janssen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.