Inflammatory Cytokines Receptors And Disease
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Cytokine Induced Pathology
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Author : G. W. Richter
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Cytokine Induced Pathology written by G. W. Richter and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Health & Fitness categories.
International Review of Experimental Pathology, Volume 34: Cytokine-Induced Pathology Part B: Inflammatory Cytokines, Receptors, and Disease presents experimental findings obtained from the most recently studied cytokines and growth factors. The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-?, tumor necrosis factor- a (TNF), interleukin-8, transforming growth factor-ß, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; and the biological activity of leukemia inhibitory factor (LIF). The papers in Section II examine cytokine receptors, including their structure and signal transduction; interferon-? (IFN-?) activity; and immunoregulatory role of TNF-a. Section III is devoted to cytokine receptors, including studies on TNF properties relevant to tissue injury and its role in T cell-mediated immunopathological reactions in vivo; the role of cytokines in experimental pulmonary fibrosis induced in mice; and the role of cytokines in bacterial meningitis.
Inflammatory Cytokines Receptors And Disease
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Author : G. W. Richter
language : en
Publisher:
Release Date : 1993
Inflammatory Cytokines Receptors And Disease written by G. W. Richter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cytokines categories.
International Review of Experimental Pathology, Volume 34: Cytokine-Induced Pathology Part B: Inflammatory Cytokines, Receptors, and Disease presents experimental findings obtained from the most recently studied cytokines and growth factors. The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-y, tumor necrosis factor- a (TNF), interleukin-8, transforming growth factor-ß, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; a ...
Cytokines And Cytokine Receptors
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Author : Constantin A. Bona
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Cytokines And Cytokine Receptors written by Constantin A. Bona and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Cytokine Induced Pathology
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Author :
language : en
Publisher:
Release Date : 1993
Cytokine Induced Pathology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Cytokines As Potential Therapeutic Targets For Inflammatory Skin Diseases
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Author : R. Numerof
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19
Cytokines As Potential Therapeutic Targets For Inflammatory Skin Diseases written by R. Numerof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Medical categories.
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Pharmacology Of Cytokines
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Author : Alberto Mantovani
language : en
Publisher: Oxford University Press, USA
Release Date : 2000
Pharmacology Of Cytokines written by Alberto Mantovani and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
Cytokines are the "words" of immunity, serving as mediators within and outside the immune system. There is tremendous interest in their expliotation as therapeutic tools in diverse human diseases and considerable effort has been made to understand and utilize their pharmacology. This book examines this pharmacology, from developments and characterization of simple chemicals and their mechanism of action to the use of biotechnology-based approaches. The book puts cytokines and their pharmacology in context and examines their involvement in individual organ-disease systems.
Novel Cytokine Inhibitors
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Author : Gerry A. Higgs
language : en
Publisher: Springer
Release Date : 2012-12-06
Novel Cytokine Inhibitors written by Gerry A. Higgs and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.
Clinical Applications Of Cytokines
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Author : Joost J. Oppenheim
language : en
Publisher: Oxford University Press, USA
Release Date : 1993
Clinical Applications Of Cytokines written by Joost J. Oppenheim and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.
Toll Like Receptors In Inflammation
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Author : Luke A.J. O'Neill
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-16
Toll Like Receptors In Inflammation written by Luke A.J. O'Neill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-16 with Medical categories.
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.
Cytokines And The Cns
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Author : Richard M. Ransohoff
language : en
Publisher: CRC Press
Release Date : 2005-10-31
Cytokines And The Cns written by Richard M. Ransohoff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-31 with Medical categories.
Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist’s cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.