Innate Tolerance In The Cns
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Innate Tolerance In The Cns
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Author : Springer
language : en
Publisher:
Release Date : 2012-09-22
Innate Tolerance In The Cns written by Springer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-22 with categories.
Innate Tolerance In The Cns
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Author : Jeffrey M. Gidday
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-21
Innate Tolerance In The Cns written by Jeffrey M. Gidday and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-21 with Medical categories.
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Innate Tolerance In The Cns
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Author : Jeffrey M. Gidday
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-21
Innate Tolerance In The Cns written by Jeffrey M. Gidday and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-21 with Medical categories.
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Caffeine For The Sustainment Of Mental Task Performance
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2002-01-07
Caffeine For The Sustainment Of Mental Task Performance written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-07 with Medical categories.
This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Neurobiology Of Alcohol Dependence
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Author : Antonio Noronha
language : en
Publisher: Elsevier
Release Date : 2014-05-02
Neurobiology Of Alcohol Dependence written by Antonio Noronha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-02 with Science categories.
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Fundamentals Of Inflammation
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Author : Charles N. Serhan
language : en
Publisher: Cambridge University Press
Release Date : 2010-04-26
Fundamentals Of Inflammation written by Charles N. Serhan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-26 with Medical categories.
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Epilepsy A Comprehensive Textbook
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Author : Jerome Engel Jr
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2023-10-23
Epilepsy A Comprehensive Textbook written by Jerome Engel Jr and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-23 with Medical categories.
Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.
The Effects Of Drug Abuse On The Human Nervous System
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Author : Bertha Madras
language : en
Publisher: Elsevier
Release Date : 2013-11-15
The Effects Of Drug Abuse On The Human Nervous System written by Bertha Madras and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Psychology categories.
Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetics of use and treatment success, and strategies to screen populations and provide appropriate interventions. The book offers meaningful, relevant and timely information for scientists, health-care professionals and treatment providers. A comprehensive reference on the effects of drug addiction on the human nervous system Focuses on core drug addiction issues from nicotine, cocaine, methamphetamine, alcohol, and other commonly abused drugs Includes foundational science chapters on the biology of addiction Details challenges in diagnosis and treatment options
Neuro Immune Connections To Enable Repair In Cns Disorders
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Author : Tim Vanmierlo
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-28
Neuro Immune Connections To Enable Repair In Cns Disorders written by Tim Vanmierlo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.