Insight Into The Molecular Mechanisms Of Membrane Geometry Generation And Recognition
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Insight Into The Molecular Mechanisms Of Membrane Geometry Generation And Recognition
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Author : Richard Gill
language : en
Publisher:
Release Date : 2015
Insight Into The Molecular Mechanisms Of Membrane Geometry Generation And Recognition written by Richard Gill and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Membrane remodeling is an essential process in cell growth, division, intracellular vesicle transport, and many other essential biological phenomena. Furthermore, membrane geometry has recently been shown to regulate biological activity and determines the final cellular localization of some proteins. The aim of this thesis is to provide structural and molecular insights into the mechanism governing membrane geometry induction and recognition. SpoVM is a small peptide that was recently found to recognize and preferentially localize to the slightly curved outer surface of the forespore (diameter of curvature, R, ~1 [mu]m) during Bacillus subtilis spore development. However, little was known about how this was accomplished. We determined that the SpoVM molecule adopted an atypical amphipathic helical structure in bilayer-like bicelles and that the helix is deeply embedded into the membrane. Our study challenges the current accepted model, which is based on circular dichroism and biochemical data, and provides structural support that SpoVM uses a new molecular mechanism to sense small membrane curvature. Recent studies have linked protein intracellular trafficking to human diseases. In Alzheimer's Disease (AD), a type I membrane protein referred to as LR11 (SorLA) is a key regulator of the amyloid precursor protein (APP) trafficking. LR11 diverts APP away from amyloidogenic processing to A[beta] peptides. The accumulation of A[beta] in the brain is generally accepted as the primary cause of AD. We discovered a membrane proximal amphipathic [alpha]-helix in LR11 C-terminal domain and, moreover, this helix deforms the membrane mimic liposomes. Since changes in membraneivgeometry are inherent to trafficking events, we postulate that this helix may sense and/or induce the bending of the membrane during vesicle biogenesis to facilitate LR11 intracellular transport. Amphipathic helices play a myriad of functions in mediating protein-lipid interactions. Despite their structural simplicity, several key properties including charge, the physiochemical characteristics of the hydrophobic vs. hydrophilic face, hydrophobicity, helical length, membrane orientation, and insertion depth, can be fine-tuned for their biological functions. Our study highlights the importance to quantitatively dissect these parameters in order to mechanistically understand their functions in membrane remodeling and ultimately to be able to manipulate these properties for therapeutic uses such as in designing antimicrobial and cell penetrating peptides.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Golgi Dynamics In Physiological And Pathological Conditions
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Author : Jaakko Saraste
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-04
Golgi Dynamics In Physiological And Pathological Conditions written by Jaakko Saraste and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with categories.
Plant Endocytosis
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Author : Jozef Šamaj
language : en
Publisher: Springer
Release Date : 2014-12-03
Plant Endocytosis written by Jozef Šamaj and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Science categories.
Endocytosis is a fundamental biological process, which is conserved among all eukaryotes. It is essential not only for many physiological and signalling processes but also for interactions between eukaryotic cells and pathogens or symbionts. This book covers all aspects of endocytosis in both lower and higher plants, including basic types of endocytosis, endocytic compartments, and molecules involved in endocytic internalization and recycling in diverse plant cell types. It provides a comparison with endocytosis in animals and yeast and discusses future prospects in this new and rapidly evolving plant research field. Readers will find an overview of the state-of-the-art methods and techniques applied in plant endocytosis research.
Opportunities In Biology
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Author : National Research Council
language : en
Publisher: National Academies
Release Date : 1989-01-01
Opportunities In Biology written by National Research Council and has been published by National Academies this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-01-01 with Science categories.
Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€"recombinant DNA, scanning tunneling microscopes, and moreâ€"are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€"for funding, effective information systems, and other supportâ€"of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.
Handbook Of Materials Modeling
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Author : Sidney Yip
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-17
Handbook Of Materials Modeling written by Sidney Yip and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-17 with Science categories.
The first reference of its kind in the rapidly emerging field of computational approachs to materials research, this is a compendium of perspective-providing and topical articles written to inform students and non-specialists of the current status and capabilities of modelling and simulation. From the standpoint of methodology, the development follows a multiscale approach with emphasis on electronic-structure, atomistic, and mesoscale methods, as well as mathematical analysis and rate processes. Basic models are treated across traditional disciplines, not only in the discussion of methods but also in chapters on crystal defects, microstructure, fluids, polymers and soft matter. Written by authors who are actively participating in the current development, this collection of 150 articles has the breadth and depth to be a major contributor toward defining the field of computational materials. In addition, there are 40 commentaries by highly respected researchers, presenting various views that should interest the future generations of the community. Subject Editors: Martin Bazant, MIT; Bruce Boghosian, Tufts University; Richard Catlow, Royal Institution; Long-Qing Chen, Pennsylvania State University; William Curtin, Brown University; Tomas Diaz de la Rubia, Lawrence Livermore National Laboratory; Nicolas Hadjiconstantinou, MIT; Mark F. Horstemeyer, Mississippi State University; Efthimios Kaxiras, Harvard University; L. Mahadevan, Harvard University; Dimitrios Maroudas, University of Massachusetts; Nicola Marzari, MIT; Horia Metiu, University of California Santa Barbara; Gregory C. Rutledge, MIT; David J. Srolovitz, Princeton University; Bernhardt L. Trout, MIT; Dieter Wolf, Argonne National Laboratory.
The Giant Vesicle Book
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Author : Rumiana Dimova
language : en
Publisher: CRC Press
Release Date : 2019-11-19
The Giant Vesicle Book written by Rumiana Dimova and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-19 with Science categories.
Giant vesicles are widely used as a model membrane system, both for basic biological systems and for their promising applications in the development of smart materials and cell mimetics, as well as in driving new technologies in synthetic biology and for the cosmetics and pharmaceutical industry. The reader is guided to use giant vesicles, from the formation of simple membrane platforms to advanced membrane and cell system models. It also includes fundamentals for understanding lipid or polymer membrane structure, properties and behavior. Every chapter includes ideas for further applications and discussions on the implications of the observed phenomena towards understanding membrane-related processes. The Giant Vesicle Book is meant to be a road companion, a trusted guide for those making their first steps in this field as well as a source of information required by experts. Key Features • A complete summary of the field, covering fundamental concepts, practical methods, core theory, and the most promising applications • A start-up package of theoretical and experimental information for newcomers in the field • Extensive protocols for establishing the required preparations and assays • Tips and instructions for carefully performing and interpreting measurements with giant vesicles or for observing them, including pitfalls • Approaches developed for investigating giant vesicles as well as brief overviews of previous studies implementing the described techniques • Handy tables with data and structures for ready reference
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Electroporation Protocols
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Author : Shulin Li
language : en
Publisher: Humana Press
Release Date : 2014-02-08
Electroporation Protocols written by Shulin Li and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-08 with Medical categories.
Electroporation gene therapy, or gene electrotransfer, has evolved greatly over the last few decades as a result of the remarkable progress in genetic sequencing, gene array analysis, gene cloning, gene expression detection, DNA manufacture and discovery and synthesis of siRNA. Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. It builds on the success of the first edition and on the progress made in siRNA delivery and DNA vaccines for large animals as well as discovery of electroporation applications for the fragile tissues and for internal organs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition aims to provide not only comprehensive coverage of the basic theory and practical application of electroporation siRNA therapy, gene therapy, and vaccine, but also elaborates on the most current views from the experts in this field, serving as an invaluable resource for investigators both in and outside of this field.
Regenerative Medicine
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Author : Corey W Hunter
language : en
Publisher: Springer Nature
Release Date : 2022-08-30
Regenerative Medicine written by Corey W Hunter and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-30 with Medical categories.
This book explores the rapidly growing subspecialty of regenerative medicine in pain management. It provides concise guidelines and instruction for healthcare providers interested in implementing this novel therapy. The book contains three sections and begins with a thorough introduction to the field. Additionally, section one examines various therapies such as stem cell collection, allograft therapies, and bone marrow aspirations. Section two then delves into the medical diagnosis and procedural guidance methods, including ultrasound imaging, discography, local anesthetics, and anticoagulation medications. Following this, section three concludes the book with numerous discussions on standardized treatment paradigms. A unique, first-of-its-kind book, Regenerative Medicine seeks to inspire medical practitioners to integrate this subspecialty into pain management therapies and treatments.