Insulin Action And Hypertension
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Hypertension As An Insulin Resistant Disorder
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Author : Ulf Smith
language : en
Publisher:
Release Date : 1991
Hypertension As An Insulin Resistant Disorder written by Ulf Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
It is generally agreed that primary hypertension is a multifactorial disorder where both genetic and environmemntal factors play an important role. In recent years it has become evident that hypertension is closely associated with a number of metabolic risk factors for cardiovascular disease. Insulin resistance and hyperinsulinemia seem to play a key role in the development of these risk factors. An increasing body of evidence also suggests that insulin may be directly involved in the pathogenesis of hypertension. Thus investigators representing different disciplines and approaches have critically reviewed the molecular and clinical evidence for the role of insulin in the pathogenesis of hypertension in this volume. Also suggested are possible interactions of insulin with genetic and environmental factors. This book succeeds in generating new approaches and defining areas needing further exploration, as well as contributing to the better understanding of the subject as a whole.
Insulin Resistance
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Author : Sudhesh Kumar
language : en
Publisher: John Wiley & Sons
Release Date : 2005-01-14
Insulin Resistance written by Sudhesh Kumar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-14 with Medical categories.
Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research
Insulin Action And Hypertension
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Author : E. M. McMurray
language : en
Publisher:
Release Date : 2012
Insulin Action And Hypertension written by E. M. McMurray and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Introduction There has been renewed interest in aldosterone, with evidence that those with primary hyperaldosteronism are at great risk of cardiovascular disease and have higher mortality rates than those with essential hypertension at a similar level. However, screening for primary hyperaldosteronism can be difficult. Aldosterone is also recognised to be a pro-inflammatory hormone, its effects resulting in vascular damage and cardiac fibrosis. Mortality benefits have been demonstrated in patients with heart failure, and post-M I with LV dysfunction following treatment with mineralocorticoid receptor antagonists. There is a link between aldosterone and hypertension and impaired insulin resistance. However evidence is lacking on the effect of eplerenone on insulin action. Methods Three studies are presented. In the first two studies salivary aldosterone is measured using a newly developed assay, initially in normotensive controls and then in a hypertensive cohort. The third study was a randomised, controlled, double-blind, crossover study, investigating the effects of the selective mineralocorticoid receptor antagonist Eplerenone on insulin action in a hypertensive cohort. Results Salivary aldosterone correlated well with serum aldosterone at 1200h in both the normotensive and hypertensive cohorts. Diurnal variation in salivary aldosterone concentration was also demonstrated in both cohorts. Treatment with eplerenone did not affect insulin sensitivity as assessed by a hyperinsulinaemic euglycaemic clamp. Conclusions Salivary aldosterone is a marker for serum aldosterone and varies across the day in both normotensive and hypertensive individuals. Eplerenone has a neutral effect on insulin action in man. Overall, these studies have addressed a number of practical issues concerning screening for primary hyperaldosteronism and shown a neutral effect of MR blockade on insulin action. These issues are highly relevant to current medical practice.
Insulin Resistance
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Author : David Moller
language : en
Publisher: John Wiley & Sons
Release Date : 1993-10-15
Insulin Resistance written by David Moller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-10-15 with Health & Fitness categories.
The past two decades have seen explosive gains in our understanding of the physiology and basic mechanisms of insulin action and the critical importance of insulin resistance in the pathogenesis of clinical disorders such as non-insulin dependent diabetes mellitus, essential hypertension and atherosclerotic cardiovascular disease. Insulin Resistance offers the first comprehensive review of the field, with integrated chapters providing up to date coverage of the essential components of basic and clinical research that have contributed to current understanding of the topic. There are chapters on basic mechanisms of insulin action, in depth discussions of insulin resistance syndromes from epidemiological, clinical and biochemical viewpoints and a discussion of therapeutic approaches to insulin resistance. Insulin Resistance will be an invaluable resource for clinicians and scientists with an interest in the mechanisms of insulin action, the clinical sequelae of hyperinsulinemia and future therapies of insulin resistance.
The Metabolic Syndrome X
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Author : Barbara C. Hansen
language : en
Publisher:
Release Date : 1999
The Metabolic Syndrome X written by Barbara C. Hansen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
This collection of papers presents a discussion of the linkages between the diseases that contribute to the metabolic syndrome X - insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemias. The topic is approached from many perspectives, and potential treatment is discussed.
Insulin Resistance
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Author : Gerald M. Reaven
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04-01
Insulin Resistance written by Gerald M. Reaven and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-01 with Medical categories.
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.
Diabetes And Hypertension
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Author : Samy I. McFarlane
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Diabetes And Hypertension written by Samy I. McFarlane and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Insulin Resistance
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Author : Philip Scott Zeitler
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-28
Insulin Resistance written by Philip Scott Zeitler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-28 with Medical categories.
In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world’s population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.
The Role Of Insulin In The Development Of Hypertension
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Author : William James Towner
language : en
Publisher:
Release Date : 1989
The Role Of Insulin In The Development Of Hypertension written by William James Towner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
Dietary Lipids And Insulin Action
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Author : Iwar Klimes
language : en
Publisher:
Release Date : 1993
Dietary Lipids And Insulin Action written by Iwar Klimes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
In these conference papers, experts in diabetics, heart disease and energy provide new and valuable insights into the notion that dietary lipids may play a pivotal role in carbohydrate, lipoprotein and energy metabolism as it relates to insulin-resistant states.