Interactions Between Proteins Sugars And Surfactants
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Interactions Between Proteins Sugars And Surfactants
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Author : Christian Führling
language : en
Publisher:
Release Date : 2004
Interactions Between Proteins Sugars And Surfactants written by Christian Führling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Interfacial Interactions Between Pure Sugar Surfactants And Protein
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Author : Gorgias Garofalakis
language : en
Publisher:
Release Date : 2000
Interfacial Interactions Between Pure Sugar Surfactants And Protein written by Gorgias Garofalakis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Interactions Of Surfactants With Polymers And Proteins
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Author : E. Desmond Goddard
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Interactions Of Surfactants With Polymers And Proteins written by E. Desmond Goddard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Science categories.
Interactions of Surfactants with Polymers and Proteins covers work done in this area over the last 30 years and examines in detail the physico-chemical, microstructural, and applications aspects of interactions of surfactants with polymers and proteins in bulk surfaces and at interfaces. The physical chemistry of individual components (surfactants, polymers, and proteins) is discussed, and extensive coverage of interactions of surfactants with uncharged, oppositely charged, and hydrophobe modified polymers is provided. Other topics addressed include water soluble and insoluble keratinous proteins, the principles and applications of fluorescence spectroscopy, the physical properties and microstructural aspects of polymer/protein-surfactant complexes, and implications of surfactant interactions with polymers and proteins in practical systems. Interactions of Surfactants with Polymers and Proteins provides a wealth of information for chemists involved in a number of different research areas, including cosmetics, pharmaceutics, foods, paints, pigments, lubrication, ceramics, minerals/materials processing, and biological systems.
Investigating The Bioprotective Properties Of Sugars
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Author : Tammy Iyobosa Ehiwe
language : en
Publisher:
Release Date : 2011
Investigating The Bioprotective Properties Of Sugars written by Tammy Iyobosa Ehiwe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The purpose of this study was to investigate the stabilizing properties of osmolytes, specifically sugars on biomolecule such as protein. The strategy used in this study involved the utilisation of surfactant-rich micelles; where by the impact sugars have on the free energy of exposure of hydrocarbon groups present within the surfactant micelles was examined. The observation made for sugar-surfactant study was then applied to explain the stabilisation of the native structure and thus the physiologically active form of the protein by sugars. The sugars that have been studied include sucrose, trehalose, maltose, raffinose and mannitol. The surfactants studied were sodium decyl sulphate (SDeS), sodium dodecyl sulphate (SDS) and sodium tetradecyl sulphate (STS). Tensiometry was used to examine the impact of sugars on the critical micelle concentrations (CMC), Gibbs free energy change of micellization (Gmic), surface pressure, surface excess concentration and area occupied per surfactant molecule. The free energy penalty of hydrocarbon chain exposure was obtained from the Gibbs free energy change of demicellization(Gdemic) which is equal but opposite in sign to the Gmic. Measurements were carried out to elucidate the influence of sugar on the aforementioned surfactant properties as a function of increasing sugar concentration. Isothermal titration calorimetry (ITC) was then used to study -sugar surfactant interactions to give enthalpy (Hmic) and entropy (Smic) of micellization in addition to CMC and Gmic, thus obtaining a full thermodynamic characterisation, complementing the results obtained by tensiometry. Tensiometric results revealed that at increasing concentration of sugar, the CMC of the surfactants was decreased and a more negative Gmic was obtained. ITC results revealed a similar trend for the effect of sugar on CMC and Gmic while the Hmic and Smic was increased in the presence of the sugars. The results from surfactant studies suggest an increase in the free energy penalty of hydrocarbon group exposure to the aqueous environment, due to an unfavourable interaction between the hydrophobic groups and the aqueous sugar solution. Consequently, the aggregation process is thermodynamically favoured and more spontaneous in sugar solutions. For instance in SDeS the Gmic in water and in sugar solution showed that micellization was more favourable in sugar solution (Gmic = -19.14 kJ mol?1 at 1.0M Trehalose) than in water (Gmic = -18.44 kJ mol?1). In addition, significant increases in surface pressure of the surfactants in the presence of sugars suggest an enhancement of the surface activity of the surfactants. Increases in area occupied per surfactant molecules in the presence of sugars suggest increase in the size of the head group area thus, possible interactions between surfactant head group - sugar or sugar-water mediated interactions. Also increases Hmic in comparison to lower values of Smic obtained by calorimetry suggest possible hydrogen bonding. In conclusion, surfactant studies suggest that sugars would stabilize biological structures by a combination of both an exclusion from the hydrophobic group due to unfavourable interactions between the hydrophobic groups and possible polar interactions between polar groups. Differential scanning calorimetry (DSC) was used to study and characterise the effect of the sugars on the thermal stability of RNase A. The results revealed an increase the thermal stability of RNase A as shown by higher Tm values in the presence of sugars. Results obtained from surfactant studies were then related to DSC results, a linear relationship between the Tm and CMC values suggests a similar mechanism. Hence, though proteins are large complex molecules, their interaction with sugars or other small solutes could be related to simple model systems such as micelles.
Sugar Based Surfactants For Pharmaceutical Protein Formulations
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Author : Lars Schiefelbein
language : en
Publisher: Cuvillier Verlag
Release Date : 2011-07-25
Sugar Based Surfactants For Pharmaceutical Protein Formulations written by Lars Schiefelbein and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-25 with Medical categories.
Nonionic Surfactants, Sugar-Based Surfactants, Alkylpolyglucosides, Protein Formulations
Sugar Based Surfactants
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Author : Cristóbal Carnero Ruiz
language : en
Publisher: CRC Press
Release Date : 2008-12-09
Sugar Based Surfactants written by Cristóbal Carnero Ruiz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-09 with Science categories.
Touted as the new darling of the chemical industry, alkyl polyglycosides are gaining in popularity due to the fact that they are readily biodegradable, low-toxic, and made from renewable resources. Sugar-Based Surfactants compiles the most recent and relevant aspects of sugar-based surfactants, including self-association, phase behavior, and interfacial properties. Focusing on both colloidal and interfacial science, the book deals with the adsorption of surfactants in both the air-liquid and solid-liquid interfaces. It also covers new advances in surfactant science, such as the development of a family of potent surface active agents that are non-toxic, and thus usable in ubiquitous consumer products
Sugar Based Surfactants For Pharmaceutical Protein Formulations
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Author : Lars Kurt Johann Schiefelbein
language : en
Publisher:
Release Date : 2011
Sugar Based Surfactants For Pharmaceutical Protein Formulations written by Lars Kurt Johann Schiefelbein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Interactions Between Membrane Proteins And Commercial Surfactants
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Author : Anne Dambrine
language : en
Publisher:
Release Date : 1999
Interactions Between Membrane Proteins And Commercial Surfactants written by Anne Dambrine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Rational Design Of Stable Protein Formulations
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Author : John F. Carpenter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Rational Design Of Stable Protein Formulations written by John F. Carpenter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view. This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.
On The Interaction Between Proteins And Surfactants At The Model Substance Zein
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Author : M. J. Schwuger
language : en
Publisher:
Release Date : 19??
On The Interaction Between Proteins And Surfactants At The Model Substance Zein written by M. J. Schwuger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.