Intrigante Proposta Del Milionario

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Intrigante Proposta Del Milionario

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Author : Margaret Way
language : it
Publisher:
Release Date : 2010

Intrigante Proposta Del Milionario written by Margaret Way and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Intrigante Proposta Del Milionario

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Author : Margaret Way
language : it
Publisher: Harper Collins Italia
Release Date : 2021-06-10T00:00:00+02:00

Intrigante Proposta Del Milionario written by Margaret Way and has been published by Harper Collins Italia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-10T00:00:00+02:00 with Fiction categories.

Quando alla morte di un lontano prozio scopre di aver ereditato una tenuta, Nyree Alcott vede realizzarsi il sogno di una vita. Dopo un'infanzia priva degli affetti familiari, avrà finalmente una casa tutta sua! Con l'entusiasmo dei suoi diciannove anni Nyree parte alla volta del Queensland per prendere possesso della casa e iniziare la sua nuova vita. Ma non ha fatto i conti con Brant Hollister, giovane e affascinante proprietario della compagnia edilizia più potente del nord Australia, che ha ben altri progetti sulla faccenda, e farà di tutto per indurla a vendere. Sullo sfondo lussureggiante della natura tropicale, lo scontro dei loro punti di vista produrrà scintille. Ci vorranno il misterioso ritratto di una contessa russa e un violento ciclone perché Nyree e Brant si rendano conto che l'amore ha avuto la meglio sulla loro iniziale ostilità.

Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Sapiens

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Author : Yuval Noah Harari
language : en
Publisher: Random House
Release Date : 2014-09-04

Sapiens written by Yuval Noah Harari and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with History categories.

'Interesting and provocative... It gives you a sense of how briefly we've been on this Earth' Barack Obama What makes us brilliant? What makes us deadly? What makes us Sapiens? One of the world's preeminent historians and thinkers, Yuval Noah Harari challenges everything we know about being human. Earth is 4.5 billion years old. In just a fraction of that time, one species among countless others has conquered it: us. In this bold and provocative book, Yuval Noah Harari explores who we are, how we got here and where we're going. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY** PRAISE FOR SAPIENS: 'Jaw-dropping from the first word to the last... It may be the best book I've ever read' Chris Evans 'Startling... It changes the way you look at the world' Simon Mayo 'I would recommend Sapiens to anyone who's interested in the history and future of our species' Bill Gates

Wait With Me

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Author : Amy Daws
language : en
Publisher: Stars Hollow Publishing
Release Date : 2022-10-22

Wait With Me written by Amy Daws and has been published by Stars Hollow Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-22 with categories.

When romance novelist Kate Smith suddenly gets writer's block as she's beginning the final installment of her international bestselling steamy Bed 'n Breakfast series, she'll do pretty much anything to get her groove back.Like sneak into a Tire Depot waiting room because her words flow there just like complimentary coffee-smooth, sweet, and scorchingly hot. She manages to fly under the radar until the rugged and charming mechanic, Miles Hudson, notices the quirky redhead slinking in and out of the employees only entrance. But she's way too intriguing to blow the whistle on. Doing a test-drive of her new book idea sounds like a much better option. Now in production for film by Passionflix streaming app.

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Physics Of The Future

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Author : Michio Kaku
language : en
Publisher: Penguin UK
Release Date : 2011-05-05

Physics Of The Future written by Michio Kaku and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-05 with Science categories.

The international bestselling author of Physics of the Impossible gives us a stunning and provocative vision of the future Based on interviews with over three hundred of the world's top scientists, who are already inventing the future in their labs, Kaku-in a lucid and engaging fashion-presents the revolutionary developments in medicine, computers, quantum physics, and space travel that will forever change our way of life and alter the course of civilization itself. His astonishing revelations include: The Internet will be in your contact lens. It will recognize people's faces, display their biographies, and even translate their words into subtitles. You will control computers and appliances via tiny sensors that pick up your brain scans. You will be able to rearrange the shape of objects. Sensors in your clothing, bathroom, and appliances will monitor your vitals, and nanobots will scan your DNA and cells for signs of danger, allowing life expectancy to increase dramatically. Radically new spaceships, using laser propulsion, may replace the expensive chemical rockets of today. You may be able to take an elevator hundreds of miles into space by simply pushing the "up" button. Like Physics of the Impossible and Visions before it, Physics of the Future is an exhilarating, wondrous ride through the next one hundred years of breathtaking scientific revolution. Internationally acclaimed physicist Dr Michio Kaku holds the Henry Semat Chair in Theoretical Physics at the City University of New York. He is also an international bestselling author, his books including Hyperspace and Parallel Worlds, and a distinguished writer, having featured in Time, the Wall Street Journal, the Sunday Times and the New Scientist to name but a few. Dr Kaku also hosts his own radio show, 'Science Fantastic', and recently presented the BBC's popular series 'Time'.

The Relic

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Author : Eça de Queirós
language : en
Publisher:
Release Date : 1994

The Relic written by Eça de Queirós and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Fiction categories.

Teodorico Raposo, the novel's lascivious anti-hero is a master of deceit; one minute feigning devotion in front of his rich, pious aunt, in order to inherit her money, the next indulging in debauchery. Spurred on by the desire to please his aunt, and in order to get away from his unfaithful mistress, he embarks on a journey to the Holy Land in search of a holy relic. The resulting fiasco is a masterpiece of comic irony as religious bigotry and personal greed are mercilessly ridiculed.

Twenty Thousand Leagues Under The Sea

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Author : Jules Verne
language : en
Publisher:
Release Date : 1887

Twenty Thousand Leagues Under The Sea written by Jules Verne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1887 with Submarines (Ships) categories.