Introduction To Organ Transplantation 2nd Edition
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Introduction To Organ Transplantation 2nd Edition
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Author : Nadey S Hakim
language : en
Publisher: World Scientific
Release Date : 2012-06-07
Introduction To Organ Transplantation 2nd Edition written by Nadey S Hakim and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-07 with Medical categories.
This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation.The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.
Introduction To Organ Transplantation
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Author : Nadey Hakim
language : en
Publisher: World Scientific
Release Date : 2012
Introduction To Organ Transplantation written by Nadey Hakim and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation. The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.
Organ Transplantation Second Edition
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Author : Frank P. Stuart
language : en
Publisher: CRC Press
Release Date : 2003
Organ Transplantation Second Edition written by Frank P. Stuart and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Organ transplantation is increasingly complex and at the same time increasingly effective. The lengthening waiting list for cadaver organs now exceeds the supply several-fold. Most practicing physicians encounter only a few transplant recipients during a year of practice. This volume was written as a quick, but comprehensive, reference for medical students, residents, fellows, nurses, and practicing physicians who interface intermittently with recipients and transplant teams. It contains twentyone chapters and twelve essays; together they present the standard of practice and also controversial issues such as the ethical dilemma of long waiting lists, noncompliance with long-term immunosuppression, the relationship between acute and chronic rejection, the living organ donor, the older cadaver donor, laparoscopic nephrectomy, retransplantation, organ banks and the national transplant network’s criteria for allocating organs to potential recipients, and the promise of xenotransplantation. Appendix I includes detailed information about immunosuppressive drugs.
Introduction To Medical Ethics Patient S Interest First 2nd Edition
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Author : Arthur S M Lim
language : en
Publisher: World Scientific
Release Date : 2007-11-22
Introduction To Medical Ethics Patient S Interest First 2nd Edition written by Arthur S M Lim and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-22 with Medical categories.
Throughout history, men have repeatedly made judgments regarding their own conduct and that of their fellow men. Some acts have been judged to be right or good, while other acts have been denounced as wrong or evil. Ethical judgment in medicine, as in other areas of life, is an attempt to distinguish between good and bad conduct.This book is based on three lectures given by the author as the Medical Director of Eye Clinic Singapura International. The first lecture was an address delivered to medical undergraduates at the National University of Singapore in 1975. The second was a Commonwealth Medical Association lecture delivered a decade ago. The third was a Singapore Medical Association lecture delivered in 1981. This volume, emphasizing the principles of medical ethics, has been kept simple and brief, and it is hoped that it will make interesting reading for both medical professionals and the general public.
Transplantation At A Glance
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Author : Menna Clatworthy
language : en
Publisher: John Wiley & Sons
Release Date : 2012-06-14
Transplantation At A Glance written by Menna Clatworthy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition
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Author : Ulrike Koehl
language : en
Publisher: Frontiers Media SA
Release Date : 2018-11-13
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition written by Ulrike Koehl and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-13 with Immunologic diseases. Allergy categories.
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.
Tissue Engineering
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Author : Clemens van Blitterswijk
language : en
Publisher: Academic Press
Release Date : 2014-12-10
Tissue Engineering written by Clemens van Blitterswijk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-10 with Science categories.
Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface. Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning New edition contains material on regulatory authorities and commercial considerations in tissue engineering
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Handbook Of Intelligent Scaffolds For Tissue Engineering And Regenerative Medicine
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Author : Gilson Khang
language : en
Publisher: CRC Press
Release Date : 2017-06-26
Handbook Of Intelligent Scaffolds For Tissue Engineering And Regenerative Medicine written by Gilson Khang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-26 with Medical categories.
Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.
Principles Of Tissue Engineering
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Author : Robert Lanza
language : en
Publisher: Elsevier
Release Date : 2000-05-16
Principles Of Tissue Engineering written by Robert Lanza and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-16 with Science categories.
The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others