Iron Excess
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Handbook Of Iron Overload Disorders
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Author : James C. Barton
language : en
Publisher: Cambridge University Press
Release Date : 2010-07-22
Handbook Of Iron Overload Disorders written by James C. Barton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-22 with Medical categories.
A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.
Iron And Your Health
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Author : Thomas F. Emery
language : en
Publisher: CRC Press
Release Date : 1991-05-21
Iron And Your Health written by Thomas F. Emery and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-21 with Medical categories.
This book examines health problems ranging from heart attacks to cancer that may be associated with excess dietary iron. Much of the material is quite controversial and challenges current dogma practiced by physicians and nutritionists. The book relays important, although little know facts about iron metabolism and encourages its readers to carefully examine their beliefs concerning the benefits of routine dietary iron supplementation. Topics include iron overload, iron and infection, iron and milk, folkloric iron, and heart attacks and cancer.
Iron As Therapeutic Targets In Human Diseases
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Author : Paolo Arosio
language : en
Publisher: MDPI
Release Date : 2020-02-11
Iron As Therapeutic Targets In Human Diseases written by Paolo Arosio and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-11 with Science categories.
Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.
Exposing The Hidden Dangers Of Iron
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Author : Eugene D. Weinberg
language : en
Publisher: Cumberland House Publishing
Release Date : 2004
Exposing The Hidden Dangers Of Iron written by Eugene D. Weinberg and has been published by Cumberland House Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Iron categories.
Iron is one of the most frequently purchased over-the-counter supplements, second only to vitamin C and calcium. The danger is that, once absorbed, iron can only be excreted in minute amounts of less than one milligram a day (or by heavy blood loss), and excess iron collects in a person's vital organs, thus, setting the disease process under way. As organs literally rust away, patients can experience early death by heart attack, arthritis, liver, pancreatic and colon cancer, increased infections, cirrhosis, diabetes, neurological problems, loss of hearing, tinnitus, depression, impotence, and infertility. Scientists have now discovered a connection to iron impropriety and Alzheimer's, early onset Parkinson's, Huntington's, attention deficit disorder, and epilepsy. EXPOSING THE HIDDEN DANGERS OF IRON is an excellent introduction for medical professionals to the intricacies of iron in the various body systems. Containing a practical guide to diagnosis, it also includes such subjects as the treatment and management of iron-loading conditions, excellent reference charts, a large glossary of terms, additional resources, contact and treatment centers, and a complete bibliography. Cutting edge scientific findings are summarized, complete with endnotes and references, about the devastation of excess iron on the liver, pancreas, gallbladder, spleen, adrenals, kidneys, bone marrow, arteries, heart, pituitary, joints, lungs, hearing, skin, vision, and the brain.
Iron Deficiency And Overload
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Author : Shlomo Yehuda
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Iron Deficiency And Overload written by Shlomo Yehuda and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Medical categories.
Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.
Iron Chelation Therapy
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Author : Chaim Hershko
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Iron Chelation Therapy written by Chaim Hershko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
A Review Of The Significance Of Dietary Iron On Iron Storage Phenomena
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Author :
language : en
Publisher:
Release Date : 1972
A Review Of The Significance Of Dietary Iron On Iron Storage Phenomena written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972 with Iron categories.
Abstract: A review of current research focuses on possible effects of increased iron enrichment of wheat flour. Health hazards associated with hereditary iron storage disorders that might accrue from increased iron consumption are assessed. Factors relating to iron metabolism include the importance of the intestinal mucosa in regulating iron absorption, the phenomena of iron storage, the significance of heme and nonheme iron, and the iron compounds of the body. The diseases and disorders characterized by excess body iron are hemosiderosis, hemochromatosis, and certain anemias. While considerable research has been done on iron nutriture, the details of absorption, transport, utilization, storage, and excretion are not well understood. Dietary calculations revealed tha increased flour enrichment would raise the average daily intakes of males and females. It is concluded that this increase will have little impact on the iron accumulation of normal males, and will not precipitate hereditary iron storage disorders. (cj).
Iron And Human Disease
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Author : R.B. Lauffer
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Iron And Human Disease written by R.B. Lauffer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.
Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.
Iron As Therapeutic Targets In Human Diseases
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Author : Paolo Arosio
language : en
Publisher: MDPI
Release Date : 2020-02-11
Iron As Therapeutic Targets In Human Diseases written by Paolo Arosio and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-11 with Science categories.
Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.
Iron Disorders An Issue Of Hematology Oncology Clinics
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Author : Matthew M. Heeney
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-08-28
Iron Disorders An Issue Of Hematology Oncology Clinics written by Matthew M. Heeney and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-28 with Medical categories.
This issue of Hematology/Oncology Clinics, guest edited by Drs. Matthew Heeney and Alan Cohen, is devoted to Iron Disorders. Articles in this issue include: Hereditary Hemochromatosis (HFE and Non-HFE); Iron Refractory Iron Deficiency Anemia (IRIDA); Sideroblastic Anemia; Anemia of Chronic Disease/Inflammation; Pathophysiology of Transfusional Iron Overload; Transfusional Iron Overload and Iron Chelation Therapy; Iron Overload and its Management in Non-Transfusion-Dependent Thalassemia; Treatment of Iron Deficiency Anemia; and Iron Overload Assessment.
