Iron Chelation Therapy
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Iron Chelation Therapy
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Author : Chaim Hershko
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Iron Chelation Therapy written by Chaim Hershko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Essential Metals In Medicine Therapeutic Use And Toxicity Of Metal Ions In The Clinic
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Author : Peggy L. Carver
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2019-01-14
Essential Metals In Medicine Therapeutic Use And Toxicity Of Metal Ions In The Clinic written by Peggy L. Carver and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-14 with Science categories.
Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.
The Development Of Iron Chelators For Clinical Use
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Author : Raymond J. Bergeron
language : en
Publisher: CRC Press
Release Date : 1993-12-06
The Development Of Iron Chelators For Clinical Use written by Raymond J. Bergeron and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-12-06 with Medical categories.
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.
Iron Chelating Therapy
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Author :
language : en
Publisher:
Release Date : 1989
Iron Chelating Therapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Chelation therapy categories.
Chelation Therapy In The Treatment Of Metal Intoxication
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Author : Jan Aaseth
language : en
Publisher: Academic Press
Release Date : 2016-04-18
Chelation Therapy In The Treatment Of Metal Intoxication written by Jan Aaseth and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-18 with Medical categories.
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Chelation Therapy In Chronic Iron Overload
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Author : Edward C. Zaino
language : en
Publisher:
Release Date : 1977
Chelation Therapy In Chronic Iron Overload written by Edward C. Zaino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Chelation Therapy In Chronic Iron Overload
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Author : Edward C. Zaino
language : en
Publisher:
Release Date : 1977
Chelation Therapy In Chronic Iron Overload written by Edward C. Zaino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Blood categories.
Chelation Therapy In Chronic Iron Overload
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Author : Zaino
language : en
Publisher:
Release Date : 1979
Chelation Therapy In Chronic Iron Overload written by Zaino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
The Effects Of Desferrioxamine Iron Chelation Therapy In Hypertransfused Beta Thalassemia Patients
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Author : Gail Elizabeth Mizner
language : en
Publisher:
Release Date : 1986
The Effects Of Desferrioxamine Iron Chelation Therapy In Hypertransfused Beta Thalassemia Patients written by Gail Elizabeth Mizner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Iron chelates categories.
Metal Chelation In Medicine
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Author : Robert Crichton
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-10-26
Metal Chelation In Medicine written by Robert Crichton and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-26 with Science categories.
Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.