K Nstler Komplex
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Rare And Complex Urology
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Author : Wout Feitz
language : en
Publisher: Elsevier
Release Date : 2024-02-12
Rare And Complex Urology written by Wout Feitz and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-12 with Science categories.
Rare and Complex Urology combines information on clinical aspects, network developments and patient journeys in specific rare and complex urological diseases within the ERN (European Reference Network) template structure, allowing for better diagnosis, treatment and patient outcome. Each chapter contains an introduction on specific diseases with representative clinical images followed by a clinical view on treatment options (non-surgical and surgical) with clear schema and drawings; nurse specialist views on current care, patient views on the lifelong journey and expected development and research innovations for the future. Diseases covered include those of the bladder, stone and kidney diseases, malformations, pelvic floor disorders, the female urethra, reconstruction, surgery, cancers and rare tumors. This is a must have reference for basic scientists interested in engaging in translational urology and surgery and well as urologists seeking guidance on how to implement novel research. Provides a foundation for many rare urogenital diseases and complex conditions with contributions from high-volume centres monitored by ERN eUROGEN Combines in-depth research findings with clinical information to supply state-of-the-art care solutions for rare and complex aspects of urology Removes the uncertainty of managing rare and complex urogenital cases and variations in practice
Charney Nestler S Neurobiology Of Mental Illness
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Author : Dennis S. Charney
language : en
Publisher: Oxford University Press
Release Date : 2018
Charney Nestler S Neurobiology Of Mental Illness written by Dennis S. Charney and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.
Complex Magnetic Nanostructures
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Author : Surender Kumar Sharma
language : en
Publisher: Springer
Release Date : 2017-04-04
Complex Magnetic Nanostructures written by Surender Kumar Sharma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-04 with Technology & Engineering categories.
This book offers a detailed discussion of the complex magnetic behavior of magnetic nanosystems, with its myriad of geometries (e.g. core-shell, heterodimer and dumbbell) and its different applications. It provides a broad overview of the numerous current studies concerned with magnetic nanoparticles, presenting key examples and an in-depth examination of the cutting-edge developments in this field. This contributed volume shares the latest developments in nanomagnetism with a wide audience: from upper undergraduate and graduate students to advanced specialists in both academia and industry. The first three chapters serve as a primer to the more advanced content found later in the book, making it an ideal introductory text for researchers starting in this field. It provides a forum for the critical evaluation of many aspects of complex nanomagnetism that are at the forefront of nanoscience today. It also presents highlights from the extensive literature on the topic, including the latest research in this field.
Epigenetics And Complex Traits
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Author : Anna K. Naumova
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-17
Epigenetics And Complex Traits written by Anna K. Naumova and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-17 with Medical categories.
This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease. The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics.
Unravelling The Complex And Multifaceted Role Of The Cerebellum In Health And Disease
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Author : Marija Cvetanovic
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-20
Unravelling The Complex And Multifaceted Role Of The Cerebellum In Health And Disease written by Marija Cvetanovic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Science categories.
Memory And Motivational Emotional Processes
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Author : Antonella Gasbarri
language : en
Publisher: Frontiers E-books
Release Date :
Memory And Motivational Emotional Processes written by Antonella Gasbarri and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
It is well established that memory for emotional information is generally better than for neutral information. This Research Topic comprises a set of papers focusing on memory and its relation with motivational and emotional processes, ranging from electroencephalographic evidences of emotional modulation of memory systems, to the role of neurotransmitters/neuromodulators (i.e. endocannabinoid, glucocorticoid, serotonin, noradrenergic, dopaminergic systems), and second messengers on emotional memory, and the specific involvement of cerebral areas on the relation between memory and motivational/emotional processes (i.e. prefrontal cortex, amygdala, accumbens). In particular, some of the topics discussed in this Research Topic will include: cortical activity correlates of emotional modulation of memory systems, interactions between ascending vagal fibers and central noradrenergic systems in modulating memory for emotionally arousing events, involvement of prefrontal /accumbal catecholamine system in processing emotional and motivational salience, role of both negative and positive emotional arousal in increasing persistence of consolidated memories through modulation of second messengers and the involvement of emotional arousal in the activation of amygdala projections, that can then modulate different types of memory.
Complex Systems Science In Biomedicine
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Author : Thomas Deisboeck
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-13
Complex Systems Science In Biomedicine written by Thomas Deisboeck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-13 with Medical categories.
Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
The Complex Biopsychosocial Interactions That Create Stress Resilience
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Author : Deborah Suchecki
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-12
The Complex Biopsychosocial Interactions That Create Stress Resilience written by Deborah Suchecki and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-12 with Science categories.
Boundaries Of A Complex World
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Author : Andrei Ludu
language : en
Publisher: Springer Nature
Release Date : 2022-09-24
Boundaries Of A Complex World written by Andrei Ludu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-24 with Science categories.
The 2nd edition of this book provides novel topics and studyies in boundaries of networks and Big Data Systems.The central theme of this book is the extent to which the structure of the free dynamical boundaries of a system controls the evolution of the system as a whole. Applying three orthogonal types of thinking - mathematical, constructivist and morphological, it illustrates these concepts using applications to selected problems from the social and life sciences, as well as economics. In a broader context, it introduces and reviews some modern mathematical approaches to the science of complex systems. Standard modeling approaches (based on non-linear differential equations, dynamic systems, graph theory, cellular automata, stochastic processes, or information theory) are suitable for studying local problems. However they cannot simultaneously take into account all the different facets and phenomena of a complex system, and new approaches are required to solve the challenging problem of correlations between phenomena at different levels and hierarchies, their self-organization and memory-evolutive aspects, the growth of additional structures and are ultimately required to explain why and how such complex systems can display both robustness and flexibility. This graduate-level text addresses a broader interdisciplinary audience, keeping the mathematical level essentially uniform throughout the book, and involving only basic elements from calculus, algebra, geometry and systems theory.
Approaching Complex Diseases
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Author : Mariano Bizzarri
language : en
Publisher: Springer Nature
Release Date : 2020-04-17
Approaching Complex Diseases written by Mariano Bizzarri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Medical categories.
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.