Laboratory And Clinical Studies Of The Heart Contractile Force Effects Of Several Cardiovascular Drugs
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Laboratory And Clinical Studies Of The Heart Contractile Force Effects Of Several Cardiovascular Drugs
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Author : Thomas D. Darby
language : en
Publisher:
Release Date : 1956
Laboratory And Clinical Studies Of The Heart Contractile Force Effects Of Several Cardiovascular Drugs written by Thomas D. Darby and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1956 with categories.
Drug Discovery And Evaluation Pharmacological Assays
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Author : Hans Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-30
Drug Discovery And Evaluation Pharmacological Assays written by Hans Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-30 with Medical categories.
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Regulation Of Cardiac Contractility
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Author : R. John Solaro
language : en
Publisher: Biota Publishing
Release Date : 2011-04-01
Regulation Of Cardiac Contractility written by R. John Solaro and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-01 with Medical categories.
Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.
How Tobacco Smoke Causes Disease
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Author : United States. Public Health Service. Office of the Surgeon General
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Cardiovascular Disability
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2010-12-04
Cardiovascular Disability written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-04 with Medical categories.
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
The Breathless Heart
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Author : Michele Emdin
language : en
Publisher: Springer
Release Date : 2016-11-25
The Breathless Heart written by Michele Emdin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-25 with Medical categories.
This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.
Pediatric Cardiac Surgery
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Author : Constantine Mavroudis
language : de
Publisher: John Wiley & Sons
Release Date : 2023-01-19
Pediatric Cardiac Surgery written by Constantine Mavroudis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-19 with Medical categories.
Der Bereich der pädiatrischen Herz- und Gefäßchirurgie umfasst nicht nur die Herzchirurgie bei Säuglingen und Kindern, sondern auch die Herzchirurgie bei Erwachsenen zur Korrektur von angeborenen Herzfehlern. Da die Kindersterblichkeit aufgrund von Herzfehlern zurückgeht und Patienten mit angeborenen Herzfehlern zunehmend ein langes, gesundes Leben führen, ergeben sich neue Herausforderungen. Somit war der Bedarf an Einführungen in diesen lebensrettenden Bereich noch nie so groß. Pediatric Cardiac Surgery ist ein gut verständliches, umfassendes Lehrbuch, das diesen Bedarf seit über dreißig Jahren erfüllt und von Fachleuten auf allen Ebenen genutzt wird. Das Lehrwerk, das zahlreiche farbige Abbildungen enthält, bietet zunächst eine wissenschaftliche Einführung in die kardiovaskuläre Entwicklung und dann detaillierte Analysen von Defekten in verschiedenen Bereichen des Herzens mit den entsprechenden Verfahren zur Korrektur dieser Defekte. Die aktualisierte fünfte Auflage berücksichtigt die neuesten wissenschaftlichen Erkenntnisse und bleibt damit ein unverzichtbares Werk zu diesem Thema. Die fünfte Auflage von Pediatric Cardiac Surgery enthält unter anderem: * Beiträge von über 75 nationalen und internationalen Experten auf dem Gebiet * Beeindruckende anatomische Illustrationen von Rachid Idriss * Neue Kapitel, in denen der neueste Stand der Forschung dargestellt wird, sowie neue Inhalte in Bezug auf die kardiale Bildgebung und die medizinische Ausbildung Pediactric Cardiac Surgery ist ein wichtiges Nachschlagewerk für Herzchirurgen, die sich auf Kinder und Erwachsene spezialisiert haben, Kardiologen und alle medizinischen Fachkräfte, die mit pädiatrischen oder erwachsenen Herzpatienten arbeiten.
Stress Echocardiography
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Author : Eugenio Picano
language : en
Publisher: Springer Nature
Release Date : 2023-10-19
Stress Echocardiography written by Eugenio Picano and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-19 with Medical categories.
This is the seventh edition of a long-selling book (first edition 1991) that was translated into Italian, French, Chinese, Portuguese, Spanish, English. In the last ten years, stress echocardiography has exploded in its breadth and variety of applications. From a one-fits-all approach (wall motion by 2D-echo in the patient with known or suspected coronary artery disease), the field has progressed to an omnivorous, next-generation laboratory employing a variety of technologies (from M-Mode to 2D, from pulsed, continuous, color and tissue Doppler to lung ultrasound) on patients covering the entire spectrum of severity (from elite athletes to patients with end-stage heart failure) and ages (from children with congenital heart disease to the elderly with aortic stenosis). This new edition is enriched with over 300 figures, 150 tables and video-clips. In a societal and economic climate of increasing pressure for appropriate, justified and optimized imaging, stress echocardiography offers the great advantages of being radiation-free, relatively low cost, with minimal environmental impact, and with a staggering versatility: we can get more (information) with less (cost and risk). The volume will be a tremendous aid to current best practices for all health operators who intend to use stress echocardiography and ultrasound for diagnosis and guidance of optimal management in their patients.
Cardiac Dynamics
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Author : J. Baan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiac Dynamics written by J. Baan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cardiac Dynamics is the name of a relatively young field of study, born from the fruitful interaction between branches of two different disciplines: medicine and physics. "Dynamics" is the branch of physics which deals with the action of forces on bodies or particles in motion or at rest. "Cardiac" relates to the clinical field of cardiology but also to cardiophysiology, both of which are specialized branches of medicine. Narrower than the well established field of Hemodynamics, Cardiac Dynamics is restricted to dynamic phenomena occurring in and around the heart. The mathematical treatment of such phenomena, however, is vastly more complex because of the intricate nature of the mechanisms involved in the cardiac action. Thus, whereas hemodynamics is concerned with predominantly passive (visco-) elastic structures - vessels - containing time-variant flow of viscous flui- blood -, the mechanical study of the heart requires additional con siderations such as: active elastic components representing the contractile mechanism of cardiac muscle, complex geometry and fiber structure in the myocardial wall, autoregulatory mechanisms, and intricate flow patterns associated with valve motion. Viewed in this light it is not surprising that attempts to describe ventricular pump function and to quantify contractile performance have not reached the level of sophistication which is common in e. g. arterial hemodynamics. For the same reason, many of the often simplified approaches to describe ventricular mechanics failed to stand up to more rigorous theoretical, experimental or clinical testing.
Caffeine In Food And Dietary Supplements
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Author : Leslie A. Pray
language : en
Publisher:
Release Date : 2014
Caffeine In Food And Dietary Supplements written by Leslie A. Pray and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Health & Fitness categories.
Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.