Langerhans Cells In Autoimmunity New Perspectives In Function And Homeostasis
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Langerhans Cells In Autoimmunity New Perspectives In Function And Homeostasis
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Author : Miguel-Angel Gutierrez
language : en
Publisher:
Release Date : 2018
Langerhans Cells In Autoimmunity New Perspectives In Function And Homeostasis written by Miguel-Angel Gutierrez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Langerhans cells (LC) are the premier antigen presenting cells on epithelial surfaces. The key to LCs' functions is their residence in peripheral tissues as well as their capacity to migrate to local draining lymphoid organs. The present dissertation's goal is to elucidate the specific roles LCs play in the context of autoimmunity, by employing a mouse model genetically prone to develop multi-organ autoimmune disease, in which LCs can be traced and selectively depleted in vivo. Previous studies have elucidated LCs' ability to induce tolerance against skin-specific self-antigen and as well as to protect against the development of autoimmune skin inflammation. However, LCs' role in other, non-skin, organs where they are present, such as in cornea on eye surface and in gastric and genital mucosa, remains largely unknown. We found that LCs were altered in distribution and density in the cornea of autoimmune-prone mice. Importantly, aselective depletion of LCs led to acceleration of corneal inflammation, along with increased T cell activation and proliferation in eye-draining lymph nodes. These data allowed us to show for the first time that LCs play a protective role against corneal autoimmune disease, potentially through inhibition of T cell activation in a tissue-specific manner. Homeostatic migration of LCs from their tissue of residence to local draining lymph nodes is a hallmark of LC biology, however, the underlying mechanisms are largely unclear. We studied mechanism of LCs migration using models of autoimmune dermatitis, where LC migration was previously shown to be defective prior to the onset of clinical disease. We demonstrate that skin-resident dendritic epidermal T cells are reduced in the epidermis of these autoimmune-prone mice, and that a glycolipid that ameliorates skin inflammation restores DETCs and LC migration. This rescue of LC migration in autoimmune mice by skin-resident dendritic epidermal T cells is mediated, at least in part, via CD40-CD40L signaling. Such 'local' control of migratory behavior of tissue-resident dendritic cells can regulate systemic immune response in a tissue-specific manner, which has important implications for protection against inflammation, autoimmune diseases and graft rejection, and vaccination against cancers and infections.
Epidermal Langerhans Cells
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Author : Gerold Schuler
language : en
Publisher: CRC Press
Release Date : 1990-12-26
Epidermal Langerhans Cells written by Gerold Schuler and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-12-26 with Medical categories.
Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.
The Eye E Book
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Author : John V. Forrester
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-02-19
The Eye E Book written by John V. Forrester and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-19 with Medical categories.
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today’s ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vison scientists – other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye – anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations.
New Insights On Liver Transplant And Tolerance
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Author : Xiao-Kang Li
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-24
New Insights On Liver Transplant And Tolerance written by Xiao-Kang Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
The Eye
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Author : John V. Forrester
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-06-01
The Eye written by John V. Forrester and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Medical categories.
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vision scientists - other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye - anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations Comes with complete electronic version
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Immunopharmacology
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Author : Manzoor M. Khan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Immunopharmacology written by Manzoor M. Khan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Diabetes Mellitus In Children
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Author : Mark A. Sperling
language : en
Publisher:
Release Date : 2005
Diabetes Mellitus In Children written by Mark A. Sperling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Children categories.
Oxford Textbook Of Rheumatology
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Author : Philip Conaghan
language : en
Publisher: Oxford University Press
Release Date : 2013-10
Oxford Textbook Of Rheumatology written by Philip Conaghan and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10 with Medical categories.
A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.