Lectins And Glycobiology
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Lectins And Glycobiology
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Author : Hans-Joachim Gabius
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Lectins And Glycobiology written by Hans-Joachim Gabius and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The intriguing complexity, precision, and regulation of the wide range of biologi cal processes is determined by intricate mechanisms of molecular recognition. Their nature is under intense scrutiny. In addition to the well-appreciated interac tion of proteins either with amino acid or nucleotide sequences, the investigation of their interplay with carbohydrate elements of cellular glycoconjugates current ly exerts increasing attraction. In the group of carbohydrate-binding proteins, lec tins are distinguished from antibodies or ligand-affecting enzymes, according to the most recent definition. The thorough analysis of their structure and function is considered as a focus to collect a critical mass of information for delineating details of a further array of biochemical processes with pivotal physiological im pact. Following an already century-long history of scientific description, reflected by subjectively chosen highlights (see the Brief History of Lectin Research at page VI), the excitement in glycobiological research that prevails today can easily be ex plained by our growing awareness of the multifarious significance of a sugar-code system of biological information. This present notion unmistakably has an im pact on lines of research in diverse disciplines like cell and molecular biology, histochemistry, or clinical sciences. It also prompts inherent practical questions such as how to obtain lectins, or how to employ them as instruments in various assay systems with the best possible results. Thus, this book is devoted intentionally to cover the techniques in different research fields that deal with lectins.
Lectins And Glycobiology
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Author : Hans-Joachim Gabius
language : en
Publisher: Springer
Release Date : 1993-01-01
Lectins And Glycobiology written by Hans-Joachim Gabius and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-01 with Glycoconjugates categories.
The role of lectins and glycoconjugates in various cellular processes is receiving increasing interest. Since many cellular glycoconjugates are ligands for lectins, they are used as efficacious tools in biochemistry and cell research. "Lectins and Glycobiology" provides all relevant techniques to investigate the structure and function of lectins and their various reactions. Included are methods for the preparation ofsynthetic carbohydrate ligands, the determination of physico-chemical properties of lectin- oligosaccharide interactions, the isolation and chemical modi- fication of lectins, and assays to detect and quantitate lectins. Several chapters focus on the study of signal transduction and cellular responses induced by lectins as well as on cellular adhesion and cell recognition involving lectin-glycoprotein interaction. Further major topics are molecular biological techniques such as the use of recombinant or mutant lectin genes.
Plant Glycobiology A Sweet World Of Lectins Glycoproteins Glycolipids And Glycans
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Author : Els J. M. Van Damme
language : en
Publisher: Frontiers Media SA
Release Date : 2015-02-12
Plant Glycobiology A Sweet World Of Lectins Glycoproteins Glycolipids And Glycans written by Els J. M. Van Damme and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-12 with Botany categories.
Plants synthesize a wide variety of unique glycan structures which play essential roles during the life cycle of the plant. Being omnipresent throughout the plant kingdom, ranging from simple green algae to modern flowering plants, glycans contribute to many diverse processes. Glycans can function as structural components in the plant cell wall, assist in the folding of nascent proteins, act as signaling molecules in plant defense responses or (ER) stress pathways, or serve within the energy metabolism of a plant. In most cases, glycans are attached to other macromolecules to form so-called glycoconjugates (e.g. glycoproteins, proteoglycans and glycolipids), but they can also be present as free entities residing in the plant cell. Next to the broad, complex set of glycans, plants also evolved an elaborate collection of lectins or proteins with a lectin-like domain, which can recognize and bind to endogenous (plants-own) or exogenous (foreign) glycans. Though still poorly understood in plants, the dynamic interactions between lectins and carbohydrate structures are suggested to be involved in gene transcription, protein folding, protein transport, cell adhesion, signaling as well as defense responses. As such, a complex and largely undetermined glycan-interactome is established inside plant cells, between cells and their surrounding matrix, inside the extracellular matrix, and even between organisms. Studying the biological roles of plant glycans will enable to better understand plant development and physiology in order to fully exploit plants for food, feed and production of pharmaceutical proteins. In this Research Topic, we want to provide a platform for articles describing the latest research, perspectives and methodologies related to the fascinating world of plant glycobiology, with a focus on following subjects: 1. Identification and characterization of plant glycans, their biosynthetic and degradation enzymes 2. Characterization of plant lectins and glycoproteins 3. Plant glycans in the plant’s energy metabolism 4. Role of plant glycans in plant defense signaling 5. Use of plant lectins in pest control 6. Plant lectins as new tools in human medicine 7. Glyco-engineering in plants
Essentials Of Glycobiology
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Author : Ajit Varki
language : en
Publisher: CSHL Press
Release Date : 1999
Essentials Of Glycobiology written by Ajit Varki and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Lectins And Glycobiology Ii
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Author :
language : en
Publisher:
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Lectins And Glycobiology Ii written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Marine Glycobiology Glycomics And Lectins
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Author : Yasuhiro Ozeki
language : en
Publisher: MDPI
Release Date : 2019-11-20
Marine Glycobiology Glycomics And Lectins written by Yasuhiro Ozeki and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.
Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences. This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.
Glycosciences
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Author : Hans-Joachim Gabius
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-26
Glycosciences written by Hans-Joachim Gabius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-26 with Science categories.
A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.
Lectins
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Author : Nathan Sharon
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-03
Lectins written by Nathan Sharon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-03 with Science categories.
This Second Edition brings readers up to date with all the latest findings in lectin research. Throughout this new edition, more than 200 figures and some thirty tables help readers visualize and understand key concepts and processes. The book starts with an overview of lectin research followed by a survey of the occurrence of lectins in nature. Other areas covered include the nutritional effects of lectins and their functions in nature.
Animal Lectins
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Author : Gerardo R. Vasta PhD
language : en
Publisher: CRC Press
Release Date : 2008-10-09
Animal Lectins written by Gerardo R. Vasta PhD and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-09 with Medical categories.
Introduces Groundbreaking Approaches for Assessing Lectin Function Lectins and their ligands are under quite a heavy microscope due to their potential applications to pharmacology, immunology, cancer therapy, and agriculture. With growing interest in the glycobiology field, the body of research related to lectin roles has grown at an explosive rate
Glycobiology Of The Immune Response Volume 1253
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Author : Gabriel Rabinovich
language : en
Publisher: Wiley-Blackwell
Release Date : 2012-05-29
Glycobiology Of The Immune Response Volume 1253 written by Gabriel Rabinovich and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-29 with Science categories.
Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.