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Light Chain Amyloidosis

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The Ebmt Handbook

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Author : Nicolaus Kröger
language : en
Publisher:
Release Date : 2020-10-08

The Ebmt Handbook written by Nicolaus Kröger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

The Ebmt Handbook

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Author : Nicolaus Kröger
language : en
Publisher:
Release Date : 2020-10-08

The Ebmt Handbook

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Author : Enric Carreras
language : en
Publisher: Springer
Release Date : 2019-01-03

The Ebmt Handbook written by Enric Carreras and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.

Systemic Amyloidosis Due To Monoclonal Immunoglobulins An Issue Of Hematology Oncology Clinics Of North America E Book

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Author : Raymond L. Comenzo
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-10-28

Systemic Amyloidosis Due To Monoclonal Immunoglobulins An Issue Of Hematology Oncology Clinics Of North America E Book written by Raymond L. Comenzo and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.

This issue of Hematology/Oncology Clinics, Guest Edited by Dr. Raymond L. Comenzo, is devoted to Systemic Amyloidosis due to Monoclonal Immunoglobulins. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Topics discussed in this important issue include: The Spectrum of Monoclonal Immunoglobulin Diseases, Systemic Amyloidosis due to Clonal Plasma Cell Diseases, Systemic Amyloidosis due to Low-grade Lymphomas, The Process of Amyloid Formation due to Monoclonal Immunoglobulins, Cardiac Involvement, Renal Involvement, Liver and Gastrointestinal Involvement, Peripheral Nervous System Involvement, Options for Chemotherapy, Stem-cell Mobilization and Autologous Transplant, Monoclonal Antibody Therapies, Solid Organ Transplant, Supportive Care, Patient Voices, and Future Perspectives.

Bone Marrow Plasma Cell Infiltration In Light Chain Amyloidosis

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Author : Rodru00edguez-Lobato Luis Gerardo
language : en
Publisher:
Release Date : 2017

Bone Marrow Plasma Cell Infiltration In Light Chain Amyloidosis written by Rodru00edguez-Lobato Luis Gerardo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

BONE MARROW PLASMA CELL INFILTRATION IN LIGHT-CHAIN AMYLOIDOSISCONTEXT: Prognosis of immunoglobulin light-chain (AL) amyloidosis depends mainly on the presence of cardiac involvement and the disease burden. A higher bone marrow plasma cell (BMPC) burden has been suggested as an adverse prognostic factor. OBJECTIVE: Analyze the correlation between the BMPC infiltration, clinical features and outcomes in patients with AL amyloidosis.METHODS: We reviewed the clinical records of patients with AL amyloidosis diagnosed from January 2006 to April 2016. Seventy-nine patients (42F/37M; median age at diagnosis 65) were the final study population. Median follow-up was 45 months. BMPC were identified by optic microscopic revision of May-Gru00fcnwaldu2013Giemsau2013stained BM. All 79 patients had BM samples with adequate cellularity and BMPC infiltration was evaluated by senior cytologists. A second independent revision was performed. The concordance between the results obtained by both group of cytologists was excellent (R=0.949; P0.001).RESULTS: Median BMPC infiltration at diagnosis was 11% (interquartile range [IQR] 7-18). Eighteen patients (23%) presented more than 20% BMPC infiltration. BMPC infiltration significantly correlated with the serum free light-chain difference (R=0.551; P0.001). Patients with more than 10% BMPCs had more frequent cardiac involvement (86% vs. 63%; P=0.015), more stage III or IV of the revised Mayo risk stratification system (61% vs. 29%; P=0.01), a trend towards a higher early mortality (27% vs. 11%; P=0.08) and a significantly shorter progression-free survival (PFS) (median of 18 vs. 48 months, P=0.02) and overall survival (OS) (median of 33 months vs. not reached; P=0.046). Interestingly, those patients with lower BMPC infiltration were associated with kidney involvement (86% vs. 48%; P=0.001). In the multivariate model BMPC infiltration 10% retained its independent prognostic value for worse PFS.The use of new drugs (bortezomib or lenalidomide) seemed to overcome the negative prognostic impact of a higher BMPC infiltration (3-year PFS of 47% in u2264 10% BMPC vs. 35% in 10% BMPC; P=0.29 and 3-year OS of 62% in u226410% BMPC vs. 57% in >10% BMPC; P=0.58). CONCLUSIONS: Higher BMPC infiltration in patients with AL amyloidosis was associated with increased systemic organ damage, particularly cardiac involvement, but this fact was not related to the development of myeloma features.

Identification Of Structural Determinants Of Light Chain Amyloidosis

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Author : Maura Garofalo
language : en
Publisher:
Release Date : 2020

Identification Of Structural Determinants Of Light Chain Amyloidosis written by Maura Garofalo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Thèse. Biologie. Médecine. 2020.