Luta Pela Verdade Uma Aventura Her Ica

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

On Film Festivals

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Author : Richard Porton
language : en
Publisher: Wallflower Press
Release Date : 2009

On Film Festivals written by Richard Porton and has been published by Wallflower Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Performing Arts categories.

'Dekalog' is a series of guest-edited bi-annual publications, each exploring a specific subject, film or filmmaker. This home for serious film criticism engages academia as well as other forms of contemporary film writing, and includes filmmaker interviews.

For Glory And Bol Var

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Author : Pamela S. Murray
language : en
Publisher: University of Texas Press
Release Date : 2009-09-15

For Glory And Bol Var written by Pamela S. Murray and has been published by University of Texas Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-15 with Biography & Autobiography categories.

She was a friend, lover, and confidante of charismatic Spanish American independence hero Simón Bolívar and, after her death, a nationalist icon in her own right. Yet authors generally have chosen either to romanticize Manuela Sáenz or to discount her altogether. For Glory and Bolivar: The Remarkable of Life of Manuela Sáenz, by contrast, offers a comprehensive and clear-eyed biography of her. Based on unprecedented archival research, it paints a vivid portrait of the Quito-born "Libertadora," revealing both an exceptional figure and a flesh-and-blood person whose life broadly reflected the experiences of women during Spanish America's turbulent Age of Revolution. Already married at the time of her meeting with the famous Liberator, Sáenz abandoned her husband in order to become not only Bolívar's romantic companion, but also his official archivist, a member of his inner circle, and one of his most loyal followers. She played a central role in Spanish South America's independence drama and eventually in developments leading to the consolidation of new nations. Pamela Murray, for the first time, closely examines Sáenz's political trajectory including her vital, often-overlooked years in exile. She exposes the myths that still surround her. She offers, in short, a nuanced and much-needed historical perspective, one that balances recognition of Sáenz's uniqueness with awareness of the broader forces that shaped this dynamic nineteenth-century woman.

The Utopian Impulse In Latin America

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Author : K. Beauchesne
language : en
Publisher: Springer
Release Date : 2011-10-24

The Utopian Impulse In Latin America written by K. Beauchesne and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-24 with Social Science categories.

An exploration of the concept of utopia in Latin America from the earliest accounts of the New World to current cultural production, the carefully selected essays in this volume represent the latest research on the topic by some of the most important Latin Americanists working in North American academia today.

Homer S Odyssey And The Near East

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Author : Bruce Louden
language : en
Publisher: Cambridge University Press
Release Date : 2011-01-06

Homer S Odyssey And The Near East written by Bruce Louden and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-06 with History categories.

The Odyssey's larger plot is composed of a number of distinct genres of myth, all of which are extant in various Near Eastern cultures (Mesopotamian, West Semitic, and Egyptian). Unexpectedly, the Near Eastern culture with which the Odyssey has the most parallels is the Old Testament. Consideration of how much of the Odyssey focuses on non-heroic episodes - hosts receiving guests, a king disguised as a beggar, recognition scenes between long-separated family members - reaffirms the Odyssey's parallels with the Bible. In particular the book argues that the Odyssey is in a dialogic relationship with Genesis, which features the same three types of myth that comprise the majority of the Odyssey: theoxeny, romance (Joseph in Egypt), and Argonautic myth (Jacob winning Rachel from Laban). The Odyssey also offers intriguing parallels to the Book of Jonah, and Odysseus' treatment by the suitors offers close parallels to the Gospels' depiction of Christ in Jerusalem.

Culture Urban Future

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Author : UNESCO
language : en
Publisher: UNESCO Publishing
Release Date : 2016-12-31

Culture Urban Future written by UNESCO and has been published by UNESCO Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-31 with Cities and towns categories.

Report presents a series of analyses and recommendations for fostering the role of culture for sustainable development. Drawing on a global survey implemented with nine regional partners and insights from scholars, NGOs and urban thinkers, the report offers a global overview of urban heritage safeguarding, conservation and management, as well as the promotion of cultural and creative industries, highlighting their role as resources for sustainable urban development. Report is intended as a policy framework document to support governments in the implementation of the 2030 Agenda for Sustainable Urban Development and the New Urban Agenda.

Audiovisual Catalog

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Author : National Institute on Drug Abuse. Resource Center
language : en
Publisher:
Release Date : 1978

Audiovisual Catalog written by National Institute on Drug Abuse. Resource Center and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Drug abuse categories.

La Revoluci N

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Author : Thomas Benjamin
language : en
Publisher: University of Texas Press
Release Date : 2010-01-01

La Revoluci N written by Thomas Benjamin and has been published by University of Texas Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with History categories.

The 1910 Revolution is still tangibly present in Mexico in the festivals that celebrate its victories, on the monuments to its heroes, and, most important, in the stories and memories of the Mexican people. Yet there has never been general agreement on what the revolution meant, what its objectives were, and whether they have been accomplished. This pathfinding book shows how Mexicans from 1910 through the 1950s interpreted the revolution, tried to make sense of it, and, through collective memory, myth-making, and history writing, invented an idea called "la Revolución." In part one, Thomas Benjamin follows the historical development of different and often opposing revolutionary traditions and the state's efforts to forge them into one unified and unifying narrative. In part two, he examines ways of remembering the past and making it relevant to the present through fiestas, monuments, and official history. This research clarifies how the revolution has served to authorize and legitimize political factions and particular regimes to the present day. Beyond the Mexican case, it demonstrates how history is used to serve the needs of the present.