M Todo Bil Ng E Latim Portugu S Para Medita O Do Santo Ros Rio


M Todo Bil Ng E Latim Portugu S Para Medita O Do Santo Ros Rio
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Translational Medicine


Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.


Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.



Privatization In Latin America


Privatization In Latin America
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Author : Alberto Chong
language : en
Publisher: World Bank Publications
Release Date : 2005-03-15

Privatization In Latin America written by Alberto Chong and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-15 with Business & Economics categories.


Privatization is under attack. Beginning in the 1980s, thousands of failing state-owned enterprises worldwide have been turned over to the private sector. But public opinion has turned against privatization. A large political backlash has been brewing for some time, infused by accusations of corruption, abuse of market power, and neglect of the poor. What is the real record of privatization and are the criticisms justified? 'Privatization in Latin America' evaluates the empirical evidence on privatization in a region that has witnessed an extensive decline in the state's share of production over the past 20 years. The book is a compilation of recent studies that provide a comprehensive analysis of the record of and accusations against privatization, with important recommendations for the future. Seven countries are investigated: Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, and Peru. This book will be vital to anyone interested in the privatization debate but especially to those involved in civil service reform, corporate governance, economic policy, finance, and anticorruption efforts. 'Privatization is important but controversial. While economists typically favor it, others are skeptical. This book provides strong scientific evidence that privatization has been beneficial for many Latin American countries, although some privatizations failed and some groups in society lost out. As usual, the devil is in the details: how privatization is carried out and what reforms accompany it are crucial to its success. The book is definitely an invaluable contribution to the privatization debate.' --Oliver Hart, Andrew E. Furer Professor of Economics, Harvard University



Emerging Market Economies And Financial Globalization


Emerging Market Economies And Financial Globalization
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Author : Leonardo E. Stanley
language : en
Publisher: Anthem Press
Release Date : 2018-03-15

Emerging Market Economies And Financial Globalization written by Leonardo E. Stanley and has been published by Anthem Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-15 with Business & Economics categories.


In the past, foreign shocks arrived to national economies mainly through trade channels, and transmissions of such shocks took time to come into effect. However, after capital globalization, shocks spread to markets almost immediately. Despite the increasing macroeconomic dangers that the situation generated at emerging markets in the South, nobody at the North was ready to acknowledge the pro-cyclicality of the financial system and the inner weakness of “decontrolled” financial innovations because they were enjoying from the “great moderation.” Monetary policy was primarily centered on price stability objectives, without considering the mounting credit and asset price booms being generated by market liquidity and the problems generated by this glut. Mainstream economists, in turn, were not majorly attracted in integrating financial factors in their models. External pressures on emerging market economies (EMEs) were not eliminated after 2008, but even increased as international capital flows augmented in relevance thereafter. Initially economic authorities accurately responded to the challenge, but unconventional monetary policies in the US began to create important spillovers in EMEs. Furthermore, in contrast to a previous surge in liquidity, funds were now transmitted to EMEs throughout the bond market. The perspective of an increase in US interest rates by the FED is generating a reversal of expectations and a sudden flight to quality. Emerging countries’ currencies began to experience higher volatility levels, and depreciation movements against a newly strong US dollar are also increasingly observed. Consequently, there are increasing doubts that the “unexpected” favorable outcome observed in most EMEs at the aftermath of the Global Financial Crisis (GFC) would remain.



Cooperatives Grassroots Development And Social Change


Cooperatives Grassroots Development And Social Change
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Author : Marcela Vásquez-Léon
language : en
Publisher: University of Arizona Press
Release Date : 2017-03-14

Cooperatives Grassroots Development And Social Change written by Marcela Vásquez-Léon and has been published by University of Arizona Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-14 with Business & Economics categories.


"Provides a cross-country comparison of smallholder agricultural cooperatives in Paraguay, Brazil and Colombia, revealing immense opportunities and challenges for community development, empowerment, and social change"--Provided by publisher.



Open Veins Of Latin America


Open Veins Of Latin America
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Author : Eduardo Galeano
language : en
Publisher: NYU Press
Release Date : 1997

Open Veins Of Latin America written by Eduardo Galeano and has been published by NYU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with History categories.


[In this book, the author's] analysis of the effects and causes of capitalist underdevelopment in Latin America present [an] account of ... Latin American history. [The author] shows how foreign companies reaped huge profits through their operations in Latin America. He explains the politics of the Latin American bourgeoisies and their subservience to foreign powers, and how they interacted to create increasingly unequal capitalist societies in Latin America.-Back cover.



The Land Within


The Land Within
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Author : Pedro García Hierro
language : en
Publisher: IWGIA
Release Date : 2005

The Land Within written by Pedro García Hierro and has been published by IWGIA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.


By describing the fabric of relationships indigenous peoples weave with their environment, The Land Within attempts to define a more precise notion of indigenous territoriality. A large part of the work of titling the South American indigenous territories may now be completed but this book aims to demonstrate that, in addition to management, these territories involve many other complex aspects that must not be overlooked if the risk of losing these areas to settlers or extraction companies is to be avoided. Alexandre Surralls holds a doctorate in anthropology from the School for Higher Studies in Social Sciences and is a researcher on the staff of the National Centre for Scientific Research. Pedro Garca Hierro is a lawyer from Madrid Complutense University and the Pontifical Catholic University of Peru. He has worked with various indigenous organizations, on issues related to the identification and development of collective rights and the promotion of intercultural democratic reforms.



Icts And Sustainable Solutions For The Digital Divide Theory And Perspectives


Icts And Sustainable Solutions For The Digital Divide Theory And Perspectives
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Author : Steyn, Jacques
language : en
Publisher: IGI Global
Release Date : 2010-09-30

Icts And Sustainable Solutions For The Digital Divide Theory And Perspectives written by Steyn, Jacques and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-30 with Computers categories.


ICTs and Sustainable Solutions for the Digital Divide: Theory and Perspectives focuses on Information and Communication Technologies for Development (ICT4D), which includes any technology used for communication and information. This publication researches the social side of computing, the users, and the design of systems that meet the needs of "ordinary" users.



The American Institute For Free Labor Development


The American Institute For Free Labor Development
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Author : American Institute for Free Labor Development
language : en
Publisher:
Release Date : 1970

The American Institute For Free Labor Development written by American Institute for Free Labor Development and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Labor unions categories.




The Challenge Of Slums


The Challenge Of Slums
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Author : United Nations Human Settlements Programme
language : en
Publisher: Routledge
Release Date : 2012-05-23

The Challenge Of Slums written by United Nations Human Settlements Programme and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-23 with Political Science categories.


The Challenge of Slums presents the first global assessment of slums, emphasizing their problems and prospects. Using a newly formulated operational definition of slums, it presents estimates of the number of urban slum dwellers and examines the factors at all level, from local to global, that underlie the formation of slums as well as their social, spatial and economic characteristics and dynamics. It goes on to evaluate the principal policy responses to the slum challenge of the last few decades. From this assessment, the immensity of the challenges that slums pose is clear. Almost 1 billion people live in slums, the majority in the developing world where over 40 per cent of the urban population are slum dwellers. The number is growing and will continue to increase unless there is serious and concerted action by municipal authorities, governments, civil society and the international community. This report points the way forward and identifies the most promising approaches to achieving the United Nations Millennium Declaration targets for improving the lives of slum dwellers by scaling up participatory slum upgrading and poverty reduction programmes. The Global Report on Human Settlements is the most authoritative and up-to-date assessment of conditions and trends in the world's cities. Written in clear language and supported by informative graphics, case studies and extensive statistical data, it will be an essential tool and reference for researchers, academics, planners, public authorities and civil society organizations around the world.



Pulping The South


Pulping The South
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Author : Ricardo Carriere
language : en
Publisher: Zed Books
Release Date : 1996-08-15

Pulping The South written by Ricardo Carriere and has been published by Zed Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-15 with Business & Economics categories.


The expansion of the pulp and paper industry is one of the most important causes of land and water conflicts in the South. This book examines the threat to livelihood, soil and biodiversity generated by large-scale pulpwood plantations in the South.