Macrocycles

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Practical Medicinal Chemistry With Macrocycles

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Author : Eric Marsault
language : en
Publisher: John Wiley & Sons
Release Date : 2017-09-12

Practical Medicinal Chemistry With Macrocycles written by Eric Marsault and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-12 with Science categories.

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations

Host Guest Chemistry Of Macrocycles

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Author : Tangxin Xiao
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-22

Host Guest Chemistry Of Macrocycles written by Tangxin Xiao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-22 with Science categories.

Macrocycles In Drug Discovery

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Author : Jeremy I Levin
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015

Macrocycles In Drug Discovery written by Jeremy I Levin and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.

This book will review macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. A variety of macrocyclic natural products have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds in the context of their broad chemotype as compounds composed of large rings. The medicinal chemistry of natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, is now informing the design of fully synthetic drug candidates against a variety of targets. Furthermore, as more and more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are becoming increasingly important as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. An indication of this growing importance is the fact that several companies now provide libraries of macrocyclic molecules produced by proprietary chemical technology to use for lead generation. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

Macrocycles

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Author : E. Weber
language : en
Publisher: Springer
Release Date : 1992

Macrocycles written by E. Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Chemistry, Organic categories.

Macrocycles

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Author : Frank Davis
language : en
Publisher: John Wiley & Sons
Release Date : 2011-02-23

Macrocycles written by Frank Davis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-23 with Technology & Engineering categories.

Macrocyclic molecules contain rings made up of seven or more atoms. They are interesting because they provide building blocks for synthesizing precise two or three dimensional structures – an important goal in nanotechnology. For example, they can be used to develop nanosized reaction vessels, cages, switches and shuttles, and have potential as components in molecular computers. They also have applications as catalysts and sensors. Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction this important class of molecules and describes how to synthesise them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as “pumpkins”, interlocking chains and knots. Topics covered include: principles of macrocycle synthesis simple ring compounds multi-ring aromatic structures porphyrins and phthalocanines cyclophanes crown ethers, cryptands and spherands calixarenes, resorcinarenes, cavitands, carcerands, and heterocalixarenes cyclodextrins cucurbiturils cyclotriveratylenes rotaxanes catenanes complex 3D architectures, including trefoils and knots Macrocycles: Construction, Chemistry and Nanotechnology Applications distills the essence of this important topic for undergraduate and postgraduate students, and for researchers in other fields interested in getting a general insight into this increasingly important class of molecules.

Macrocycles

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Author : Edwin Weber
language : en
Publisher: Springer
Release Date : 2013-10-03

Macrocycles written by Edwin Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-03 with Science categories.

1. P. Knops, N. Sendhoff, H.-B. Mekelburger, F. Voegtle, Bonn/FRG HighDilution Reactions - New Synthetic Applications 2. A. Ostrowicki, E. Koepp, F. Voegtle, Bonn/FRG The "Cesium Effect": Syntheses of Medio- and Macrocyclic Compounds 3. J. Dohm, F. Voegtle, Bonn/FRG Synthesis of (Strained) Macrocycles by Sulfone Pyrolysis 4. Q. Meng, M. Hesse, Zurich/Switzerland Ring Closure Methods in the Synthesis of Macrocyclic Natural Products 5. J.L. Sessler, A.K. Burrell, Austin, TX/USA Expanded Porphyrins

New Macrocycles And Their Supramolecular Perspectives

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Author : Carmine Gaeta
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-25

New Macrocycles And Their Supramolecular Perspectives written by Carmine Gaeta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with categories.

Macrocycles

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Author : Edwin Weber
language : en
Publisher: Springer
Release Date : 1991-11-29

Macrocycles written by Edwin Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-11-29 with Science categories.

Peptide Macrocycles

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Author : Matthew B. Coppock
language : en
Publisher: Humana
Release Date : 2022-10-02

Peptide Macrocycles written by Matthew B. Coppock and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-02 with Technology & Engineering categories.

This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.

Aza Crown Macrocycles

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Author : Jerald S. Bradshaw
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-17

Aza Crown Macrocycles written by Jerald S. Bradshaw and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-17 with Science categories.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Macrocycles

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