Macrolides

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Macrolide Antibiotics

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Author : W. Schönfeld
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06

Macrolide Antibiotics written by W. Schönfeld and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro lactone structures, giving historic background, basic structure-activity relation ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.

Macrolide Antibiotics

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Author : Satoshi Omura
language : en
Publisher: Academic Press
Release Date : 2002-06-10

Macrolide Antibiotics written by Satoshi Omura and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-06-10 with Medical categories.

Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.

Macrolides

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Author : Biljana Arsic
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2018-03-19

Macrolides written by Biljana Arsic and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-19 with Science categories.

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.

Macrolides As Immunomodulatory Agents

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Author : Bruce K. Rubin
language : en
Publisher: Springer Nature
Release Date : 2024-01-04

Macrolides As Immunomodulatory Agents written by Bruce K. Rubin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-04 with Medical categories.

For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.

Macrolide Antibiotics Advances In Research And Application 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Macrolide Antibiotics Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.

Macrolide Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Macrolide Antibiotics in a compact format. The editors have built Macrolide Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Macrolide Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Macrolide Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Macrolides

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Author : Biljana Arsić
language : en
Publisher:
Release Date : 2018

Macrolides written by Biljana Arsić and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

Macrolides Advances In Research And Application 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Macrolides Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.

Macrolides: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Macrolides. The editors have built Macrolides: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Macrolides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Macrolides: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The New Macrolides

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Author : Harold C. Neu
language : en
Publisher: CRC Press
Release Date : 1993-02-23

The New Macrolides written by Harold C. Neu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-02-23 with Medical categories.

This timely reference addresses the important aspects of the chemistry of the macrolides, azalides, and streptogramins; illustrates how the compounds are related; and details what structural changes are essential to achieve improved antibacterial activity and pharmacology.;Explains the in vitro activity of the new agents and compounds them to other compounds used to treat outpatient infections. Presenting the proceeding of the first international conference on the topic, The New Macrolides, Azalides, and Streptogramins discusses the intracellular activity of azalides and new macrolides against Chlamydia, Staphyloccus aureus, Listeria monocytogenes, Legionella species, etc., demonstrates the potential uses of clarithromycin, roxithromycin, and azithromycin through animal models, reviews the safety of the newly developed macrolides and macrolide-like antibiotics and summarizes drug interactions.;Describes the use of macrolides for treating respiratory infections, skin and skin structure infections, sexually transmitted diseases, and gastriontestinal infections, contains clinical trial findings of eight macrolides used to treat significant infections in children, considers the use of macrolides to manage difficult-to-treat conditions associated with HIV infection, revels the dramatic results of using clarithromycin in combination with minocycline to clear lepromatous lesions....and much more!;The New Macrolides, Azalides, and Streptogramins serves as an excellent source for infectious disease specialists and pulmonologists, internists, pharmacologists and pharmacists, microbiologists, pediatricians, epidemiologists, and medicinal and biological chemists.

Macrolides

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Author :
language : en
Publisher:
Release Date : 1993

Macrolides written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Macrolide antibiotics categories.

New Considerations For Macrolides Azalides Streptogramins And Ketolides

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Author : Stephen H. Zinner
language : en
Publisher: CRC Press
Release Date : 1999-11-22

New Considerations For Macrolides Azalides Streptogramins And Ketolides written by Stephen H. Zinner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-22 with Medical categories.

Contains plenary papers, summaries of workshop symposia, and selected extended abstracts from over 300 contributors to the Fourth International Conference on Macrolides, Azalides, Streptogramins, and Ketolides (MASK) recently held in Barcelona, Spain. This compendium traces the progress in research and development of MASK antibiotics, identifying key interactions with other drugs and important evidence concerning microbial resistance to these compounds. Highlights in vitro antibacterial activity of novel ketolide antibiotics and presents timely data on studies utilizing newly developed injectable streptogramins! With over 1280 references, tables, drawings, and photographs, New Considerations for Macrolides, Azalides, Streptogramins, and Ketolides focuses on the pharmacodynamic and pharmacokinetic behavior of azithromycin, clarithromycin, and roxithromycin clarifies the role of antibiotics in combating conditions such as atherosclerosis and Chlamydia pneumoniae surveys MASK products currently available and assesses drugs under investigation examines infections caused by resistant strains of Gram-positive cocci showcases the efficacy of antibiotics to treat respiratory infections, sexually transmitted diseases, mycobacterial infections, gastritis and ulcer diseases, and pediatric infections gives an overview of treatment for S. aureus, S. pneumoniae, and S. pyogenes, reporting on susceptibility, susceptibility testing, and the epidemiology of resistant strains and more! Evaluating the tolerability, safety, and effectiveness of the latest treatment regimens, New Considerations for Macrolides, Azalides, Streptogramins, and Ketolides is an exceptional reference for infectious disease specialists, pulmonologists, internists, microbiologists, pediatricians, epidemiologists, medicinal and biological chemists, and medical students in these disciplines.