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Macromolecules For Drug Delivery

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Targeted Delivery Of Small And Macromolecular Drugs

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Author : Ajit S. Narang
language : en
Publisher: CRC Press
Release Date : 2010-05-12

Targeted Delivery Of Small And Macromolecular Drugs written by Ajit S. Narang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-12 with Medical categories.

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou

Macromolecular Drug Delivery

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Author : Mattias Belting
language : en
Publisher: Humana Press
Release Date : 2008-10-23

Macromolecular Drug Delivery written by Mattias Belting and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-23 with Medical categories.

Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.

Advancements In Controlled Drug Delivery Systems

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Author : Verma, Shekhar
language : en
Publisher: IGI Global
Release Date : 2022-03-25

Advancements In Controlled Drug Delivery Systems written by Verma, Shekhar and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-25 with Medical categories.

The many drawbacks of conventional dosage forms and delivery systems are overcome by designing and developing controlled release drug delivery systems, and pharmaceutical and other scientists have carried out extensive and intensive investigations in the field to explore their applications. A controlled-release drug formulation can improve product efficacy and extend patent protection. As controlled drug delivery systems continue to play a vital role in delivering various types of therapeutic agents in a controlled manner, researchers are only just scratching the surface of their full potential. Advancements in Controlled Drug Delivery Systems supplies information on translating the physicochemical properties of drugs into drug delivery systems, explores how drugs are administered via various routes, and discusses recent advancements in the fabrication and development of controlled drug delivery systems. It also underlines the methodology of controlled drug delivery system preparation and the significance, disadvantages, detailed classifications, and relevant examples. Covering topics such as machine learning and oral-controlled drug delivery, this book is ideal for pharmacists, healthcare professionals, researchers, academicians, research centers, health units, students, and pharmaceutical and scientific laboratories.

The Synthesis And Characterisation Of Dendritic Macromolecules For Drug Delivery Application

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Author : Suriani Shamsudin
language : en
Publisher:
Release Date : 2012

The Synthesis And Characterisation Of Dendritic Macromolecules For Drug Delivery Application written by Suriani Shamsudin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Today, drugs used in treating disease are almost all hydrophobic, which makes them unattractive for applying to patients. To overcome this problem, an amphiphilic macromolecule was designed which can deliver drugs to the specific targeted area. Therefore, this study focuses on the synthesis of water soluble hyperbranched polymers and their application in drug delivery systems. The first part of the thesis describes the synthesis of water soluble hyperbranched polymers by the anionic-polymerisation technique, with p-nitrophenol as the core and glycidol as the monomer. The core is important to control the molecular weight of the hyperbranched polymer. We then produced five different molecular weights by varying the core to monomer ratio, which produced hyperbranched polymers with molecular weights of 4000 Da, 8000 Da, 12500 Da, 27000 Da and 50000 Da, and four different concentrations of each molecular weight, 1.00 x 10-4 M, 2.00 x 10-4 M, 4.00 x 10-4 M and 6.00 x 10-4 M. To investigate the performance of the hyperbranched polymers, four different hydrophobic molecules were studied. The molecules were naphthalene, ibuprofen, tetracarboxyphenyl porphyrin (TCPP) and anti-prion drug. Encapsulation studies showed the concentration of each molecule increased with an increase in molecular weight and concentration of the hyperbranched polymer The functionalisation of folic acid on the surface of the hyperbranched polymer would enhance the effectiveness of the polymer as a drug delivery agent for targeting in cancer treatment. The above macromolecule was synthesised by conjugation with folic acid through poly (ethylene glycol) as spacer. The final chapter of this work describes the encapsulation of two hydrophobic molecules, ibuprofen and tetracarboxyphenyl porphyrin with water soluble PAMAM dendrimers. PAMAM dendrimers from G0.5 to G2.5 were synthesised. The results showed that more drug solubilised, the concentration of both molecules increased with an increase in dendrimer concentration. Then a comparison was made between encapsulation with water soluble hyperbranched polymers and water soluble PAMAM dendrimers. Similar molecular weight was used for both polymers of 4000 Da. For both polymers, the result demonstrated that the concentration of drug rose at 2.00 x 10-4 M and plateaued at a polymer concentration of 6.00 x 10-4 M. It was suggested the above trend was due to the aggregation of polymer. The above studies make a valuable contribution to the development of good drug delivery systems.

Macromolecules As Drugs And As Carriers For Biologically Active Materials

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Author : David A. Tirrell
language : en
Publisher:
Release Date : 1985

Macromolecules As Drugs And As Carriers For Biologically Active Materials written by David A. Tirrell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Drug carriers (Pharmacy) categories.

Bioavailability Control By Drug Delivery System Design

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Author : Victor F. Smolen
language : en
Publisher: Wiley-Interscience
Release Date : 1985

Bioavailability Control By Drug Delivery System Design written by Victor F. Smolen and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.

Polymeric Drug Delivery

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Author : Sönke Svenson
language : en
Publisher:
Release Date : 2006

Polymeric Drug Delivery written by Sönke Svenson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.

Following an overview, this volume describes in twenty chapters the use of carriers such as liposomes, micelles, dendrimers, emulsion droplets, nanoparticles, and yeast cells in the (targeted) delivery of poorly water-soluble drugs, small organic molecules, macromolecules such as proteins and nucleic acids, and metal ions for molecular imaging purposes. Different routes of application are described, including oral and transepithelial delivery.