Magnetic Nanoparticle Hyperthermia As An Adjuvant Cancer Therapy With Chemotherapy
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Magnetic Nanoparticle Hyperthermia As An Adjuvant Cancer Therapy With Chemotherapy
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Author : Alicia Ailie Petryk
language : en
Publisher:
Release Date : 2013
Magnetic Nanoparticle Hyperthermia As An Adjuvant Cancer Therapy With Chemotherapy written by Alicia Ailie Petryk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical trials are being done using magnetic nanoparticle hyperthermia. The studies presented within this thesis examine several different aspects of the use of magnetic nanoparticles in hyperthermia therapies, particularly as an adjuvant treatment strategy with the chemotherapy cisplatinum. Magnetic nanoparticle (mNP) hyperthermia and microwave (915MHz) based hyperthermia were compared for treatment efficacy using induced murine flank tumors. Treatments were evaluated for normal tissue effects, cytotoxicity and resulting therapeutic ratio. In the case of the microwave comparison, mNPH demonstrated an improvement in treatment efficacy, although below statistical significance. However, there was less normal tissue damage with the mNP therapy. When examined as an adjuvant therapy with cisplatinum, it was determined that there is an enhancement of chemotherapy based therapeutic effect, when combined with magnetic nanoparticle hyperthermia. The importance of nanoparticle incubation, which results in changes in nanopartlcle distribution and cellular uptake, was also investigated. Optimization of nanoparticle distribution is essential for creating controlled and effective treatments. These studies indicated that when nanoparticles were allowed to incubate within the tumors of mice, the heating rate of the mNP was decreased. However, the tumor regrowth delay was similar to that seen with immediately activated nanoparticles. This was true both with and without cisplatinum adjuvant therapy. Systemically delivered nanoparticles for the treatment of metastatic cancer is also an attractive therapeutic approach. Cell pellets of different volumes were utilized to determine if cytotoxicity could be achieved with intracellular nanoparticles alone. Results indicate that a minimum number of cells/thermal mass is necessary to achieve intracellular nanoparticle based cytotoxic hyperthermia. In vivo, the use of cisplatinum to modify the tumor environment was investigated as a means to improve the nanoparticle concentration within the tumor. After pretreatment with cisplatinum, nanoparticle concentrations within the tumor increased as much as 3.1 times.
Nanomedicine For Cancer Therapy
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Author : Piyush Kumar
language : en
Publisher: Springer
Release Date : 2016-11-21
Nanomedicine For Cancer Therapy written by Piyush Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Technology & Engineering categories.
This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.
Nanomaterials For Magnetic And Optical Hyperthermia Applications
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Author : Raluca Maria Fratila
language : en
Publisher: Elsevier
Release Date : 2018-11-30
Nanomaterials For Magnetic And Optical Hyperthermia Applications written by Raluca Maria Fratila and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-30 with Science categories.
Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions. Explores the design of efficient nanomaterials for hyperthermia applications, allowing readers to make informed materials selection decisions Discusses the biofunctionalization of a range of nanomaterials and their interaction with living systems Provides an overview of the current clinical applications of nanomaterials in hyperthermia treatment
Magnetic Nanoparticles In Human Health And Medicine
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Author : Costica Caizer
language : en
Publisher: John Wiley & Sons
Release Date : 2021-09-08
Magnetic Nanoparticles In Human Health And Medicine written by Costica Caizer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Science categories.
Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Magnetic Nanomaterials For Hyperthermia Based Therapy Imaging And Drug Delivery
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Author : Constantin Mihai Lucaciu
language : en
Publisher:
Release Date : 2024-03-20
Magnetic Nanomaterials For Hyperthermia Based Therapy Imaging And Drug Delivery written by Constantin Mihai Lucaciu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-20 with Medical categories.
In the rapidly advancing field of nanomedicine, this Special Issue delves into the cutting-edge developments of magnetic nanoparticles (MNPs) that have revolutionized medical applications. Over the years, the remarkable progress in nanomaterials has especially paved the way for magnetic nanoparticles to emerge as key players in biomedical advancements. Magnetic nanoparticles have demonstrated exceptional properties, notably their responsiveness to external magnetic fields, enabling remote control and manipulation. This characteristic has led to their widespread adoption in biomedical applications, with a particular focus on Magnetic Resonance Imaging (MRI), Magnetic Particle Imaging (MPI), and magnetic hyperthermia (MH) for cancer treatment. This Special Issue explores the multifaceted capabilities of MNPs, showcasing their potential in hyperthermia-based therapy, medical imaging, and drug delivery. Authors contribute their latest findings on the development and application of magnetic nanomaterials, covering various aspects of medical applications, from theoretical insights to experimental breakthroughs. Researchers highlight the critical role of MNPs in cancer therapy, especially in hyperthermia-based treatments. When combined with chemotherapy, magnetic hyperthermia presents a promising strategy for cancer therapy by synergizing high temperatures with chemotherapeutic effects. The potential for MNPs to induce an immune response against tumors adds a new dimension to their therapeutic efficacy.
Clinical Applications Of Magnetic Nanoparticles
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Author : Nguyen TK Thanh
language : en
Publisher: CRC Press
Release Date : 2018-02-06
Clinical Applications Of Magnetic Nanoparticles written by Nguyen TK Thanh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-06 with Medical categories.
Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.
Superparamagnetic Materials For Cancer Medicine
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Author : Nanasaheb Thorat
language : en
Publisher: Springer Nature
Release Date : 2023-10-02
Superparamagnetic Materials For Cancer Medicine written by Nanasaheb Thorat and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-02 with Technology & Engineering categories.
This book delves into the methods of synthesis and functionalization of superparamagnetic materials, offering a deep understanding of their properties and applications. It explores the behavioral study of these materials and provides valuable insights into their diverse applications across various fields. A dedicated section focuses on in vitro and in vivo assessment, toxicology considerations, and post-application aspects. Furthermore, the book summarizes the current development of superparamagnetic materials, including an overview of ongoing clinical trials.
Antibody Targeted Magnetic Nanoparticle Hyperthermia For Cancer Therapy
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Author : B. Kozissnik
language : en
Publisher:
Release Date : 2013
Antibody Targeted Magnetic Nanoparticle Hyperthermia For Cancer Therapy written by B. Kozissnik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Antibody Targeted Magnetic Nanoparticle Hyperthermia For Cancer Therapy
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Author : Bettina Kozissnik
language : en
Publisher:
Release Date : 2013
Antibody Targeted Magnetic Nanoparticle Hyperthermia For Cancer Therapy written by Bettina Kozissnik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Complex Shaped Metal Nanoparticles
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Author : Tapan K. Sau
language : en
Publisher: John Wiley & Sons
Release Date : 2012-08-07
Complex Shaped Metal Nanoparticles written by Tapan K. Sau and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-07 with Technology & Engineering categories.
The past few years have witnessed the development of non-spherical metal nanoparticles with complex morphologies, which offer tremendous potential in materials science, chemistry, physics and medicine. Covering all important aspects and techniques of preparation and characterization of metal nanoparticles with controlled morphology and architecture, this book provides a sound overview - from the basics right up to recent developments. Renowned research scientists from all over the world present the existing knowledge in the field, covering theory and modeling, synthesis and properties of these nanomaterials. By emphasizing the underlying concepts and principles in detail, this book enables researchers to fully recognize the future research scope and the application potential of the complex-shaped metal nanoparticles, inspiring further research in this field.