Mass Spectrometry Of Peptides
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Protein And Peptide Mass Spectrometry In Drug Discovery
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Author : Michael L. Gross
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-26
Protein And Peptide Mass Spectrometry In Drug Discovery written by Michael L. Gross and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Medical categories.
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
Mass Spectrometry Of Proteins And Peptides
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Author : John R. Chapman
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Mass Spectrometry Of Proteins And Peptides written by John R. Chapman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.
Little more than three years down the line and I am already writing the Preface to a second volume to follow Protein and Peptide Analysis by Mass . What has happened in between these times to make this second venture worthwhile? New types of mass spectrometric instrumentation have appeared so that new techniques have become possible and existing techniques have become much more feasible. More particularly, however, the newer ionization te- niques, introduced for the analysis of high molecular weight materials, have now been thoroughly used and studied. As a result, there has been an en- mous improvement in the associated sample handling technology so that these methods are now routinely applied to much smaller sample amounts as well as to more intractable samples. Again, this particular community of mass spectrometry users has both increased in number and diversified. And, riding this wave of acceptance, leaders in the field have set their sights on more complex problems: molecular interaction, ion structures, quantitation, and kinetics are just a few of the newer areas reported in Mass Spectrometry of Proteins and Peptides. As with the first volume, one purpose of this collection, Mass Spectr- etry of Proteins and Peptides, is to show the reader what can be done by the application of mass spectrometry, and perhaps even to encourage the reader to venture down new paths.
Mass Spectrometry Of Peptides
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Author : Dominic M. Desiderio
language : en
Publisher: CRC Press
Release Date : 1990-11-14
Mass Spectrometry Of Peptides written by Dominic M. Desiderio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-14 with Science categories.
The purpose of this book is to collect into one volume the research done on the mass spectrometry of peptides. It balances a range of topics including theory, instrumentation, analytical techniques, and biological applications. The scope of the work contains three major sections: ionization methods, instrumental developments, and analysis of peptides. It describes 252Cf plasma desorption and laser-induced multiphoton ionization methodology. This exciting resource covers many new areas, including continuous flow FAB, quantification of human neuropeptides, and peptide mapping. It also discusses Q-FTMS, cross-links, and metal ions.
Mass Spectrometry Data Analysis In Proteomics
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Author : Rune Matthiesen
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Mass Spectrometry Data Analysis In Proteomics written by Rune Matthiesen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
This is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. The volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters.
Analysis Of Peptides And Proteins By Mass Spectrometry
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Author : C. J McNeal
language : en
Publisher:
Release Date : 1988-12-26
Analysis Of Peptides And Proteins By Mass Spectrometry written by C. J McNeal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-12-26 with Science categories.
Comprises the proceedings of the Fourth Texas Symposium on Mass Spectrometry, held at Texas A & M University, April 1988. Twenty-five papers, presented by an international gathering of mass spectroscopists and bioscientists, reveal the state of the art in the application of mass spectrometry to the life sciences. Discussed are instruments that are sensitive to femtomoles, how mass spectrometry can further peptide mapping, monitoring peptide synthesis, peptide sequencing, and much more.
The Analysis Of Peptides And Proteins By Mass Spectrometry
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Author : C. J. McNeal
language : en
Publisher:
Release Date : 1988
The Analysis Of Peptides And Proteins By Mass Spectrometry written by C. J. McNeal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.
Protein And Peptide Analysis By Mass Spectrometry
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Author : J. R. Chapman
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-08-19
Protein And Peptide Analysis By Mass Spectrometry written by J. R. Chapman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-19 with Medical categories.
Leading practitioners authoritatively describe the newest and most effective spectrometric techniques for the analysis of proteins and peptides. The areas covered range from the elucidation of primary and secondary protein structure and the rapid identification of proteins using database techniques to methods for sequencing, as well as methods for the quantitative determination of peptides. Other chapters provide detailed information on the analysis of glycoproteins and glycopeptides and on the use of mass spectrometry to probe the interactions of proteins, both covalent and noncovalent.
Mass Spectrometry Of Proteins And Peptides
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Author : Mary S. Lipton
language : en
Publisher: Humana Press
Release Date : 2008-11-01
Mass Spectrometry Of Proteins And Peptides written by Mary S. Lipton and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Science categories.
When the last edition of this book was published in 2000, the field of proteomics was in its infancy. At that time, multidimensional liquid chromatographic separations were being introduced as an alternative to traditional gel-based techniques for separating complex protein and peptide mixtures prior to mass spectrometric detection. Today, this approach – referred to as shotgun proteomics – is considered routine for lar- scale global analyses of protein mixtures. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. Much wider accessibility of hi- resolution and mass measurement accuracy instrumentation in recent years has ini- ated a new revolution in the field by providing more reliable data and shifting the focus from cataloging proteins to precisely quantifying changes in protein abundance over time and in response to stimuli. Advanced mass spectrometers and novel ion d- sociation schemes such as electron transfer/capture dissociation make it possible to venture boldly into the maze of protein posttranslational modifications, which are an integral component of understanding functional proteomics in the spatial and t- poral domains. Another area that has benefited from these advancements is top-down proteomics, an emerging method essential for characterizing various protein variants that has potentially high impact in biomedical research.
New Methods In Peptide Mapping For The Characterization Of Proteins
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Author : William S. Hancock
language : en
Publisher: CRC Press
Release Date : 1995-10-23
New Methods In Peptide Mapping For The Characterization Of Proteins written by William S. Hancock and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-23 with Medical categories.
This text is devoted to the characterization of recombinant DNA-derived proteins by peptide mapping. It describes new technological procedures including capillary electrophoresis, analysis of glycopeptides and the use of electrospray and matrix-assisted laser desorption mass spectrometry. The book presents practical procedures for preparing a protein sample, the enzyme digestion, choice of separation method and procedures for the structural analysis of the separated species. Many figures of peptide maps illustrate typical results. Tables of summary information about digestion, separation conditions, and analyses of important protein samples are also presented.
Introduction To Protein Mass Spectrometry
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Author : Pradip K. Ghosh
language : en
Publisher: Elsevier
Release Date : 2024-04-26
Introduction To Protein Mass Spectrometry written by Pradip K. Ghosh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-26 with Science categories.
Introduction to Protein Mass Spectrometry, Second Edition provides a comprehensive overview of this increasingly important, yet complex, analytical technique. This book enables readers to understand how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. This new edition is fully updated to include the latest developments in the field and will feature new content covering recent progress in the areas where there have been the most exciting advances. These include PNNL’s multilevel-PCB-based SLIM realization, SLIM-Agilent QQQ field trials; employment of SLIM-IMS-cryo-IR combination in molecular structure determination; proximity-labelling mass spectrometry, and applications in neuroscience. Offers up-to-date, introductory information for scientists and researchers new to the field, as well as advanced insights into the critical assessment of computer-analyzed mass spectrometric results and their current limitations Provides examples of commonly used MS instruments from a range of key manufacturers/developers, including Bruker, Applied Biosystems, JEOL, Thermo Scientific/Thermo Fisher Scientific, IU, Waters and PNNL Includes biological applications and exploration of analytical tools and databases for bioinformatics Features definitions, case studies, and recent developments in protein mass spectrometry Includes sections new to this edition on SLIM (Structures for Lossless Ion Manipulation) and mass spectrometry applications in neuroscience, including synaptic biology and Alzheimer’s disease