Mechanics Of Cellular Bone Remodeling
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Mechanics Of Cellular Bone Remodeling
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Author : Qing-Hua Qin
language : en
Publisher: CRC Press
Release Date : 2013-01-08
Mechanics Of Cellular Bone Remodeling written by Qing-Hua Qin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-08 with Medical categories.
Research on bone remodeling has resulted in much new information and has led to improvements in design and biomedical practices. Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects presents a unified exploration of recent advances, giving readers a sound understanding of bone remodeling and its mathematical representation. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads. Topics include: Fundamental concepts and basic formulations for bone remodeling Applications of formulations to multifield internal bone remodeling of inhomogeneous long cylindrical bone Theory and solution of multifield surface bone remodeling A hypothetical regulation mechanism on growth factors for bone modeling and remodeling under multifield loading The RANK–RANKL–OPG pathway and formulation for analyzing the bone remodeling process A model of bone cell population dynamics for cortical bone remodeling under mechanical and pulsed electromagnetic stimulus Recent developments in experiments with bone materials Readers will benefit from the thorough coverage of general principles for each topic, followed by detailed mathematical derivations and worked examples, as well as tables and figures where appropriate. The book not only serves as a reliable reference but is also destined to attract interested readers and researchers to a field that offers fascinating and technologically important challenges.
Multiscale Mechanobiology Of Bone Remodeling And Adaptation
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Author : Peter Pivonka
language : en
Publisher: Springer
Release Date : 2017-06-20
Multiscale Mechanobiology Of Bone Remodeling And Adaptation written by Peter Pivonka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Science categories.
The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
Bone Remodeling Process
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Author : Rabeb Ben Kahla
language : en
Publisher: Academic Press
Release Date : 2021-08-14
Bone Remodeling Process written by Rabeb Ben Kahla and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-14 with Technology & Engineering categories.
Bone Remodeling Process: Mechanics, Biology, and Numerical Modeling provides a literature review. The first part of the book discusses bones in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and the second discusses pathological conditions, highlighting the attack vectors of each bone disease. The third part is devoted to the mathematical descriptions of bone remodeling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics.This book creates an overall image of the complex communication network established between the diverse remodeling actors, based on overwhelming control evidence revealed over recent years, as well as visualizes the remodeling defects and possible treatments in each case. It also regroups the models allowing readers to analyze and assess bone mechanical and biological properties. This book details the cellular mechanisms allowing the bone to adapt its microarchitecture to the requirements of the human body, which is the main issue in bone biology and presents the evolution of mathematical modeling used in a bone computer simulation. Each chapter covers a core topic in bone biomechanics Provides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulation Draws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodeling process
Bone Adaptation
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Author : Yoshitaka Kameo
language : en
Publisher: Springer
Release Date : 2018-01-10
Bone Adaptation written by Yoshitaka Kameo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-10 with Technology & Engineering categories.
This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
Bone Remodeling And Mechanomics
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Author : Madge Martin
language : en
Publisher:
Release Date : 2019
Bone Remodeling And Mechanomics written by Madge Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Our skeleton, an essential structure for the human body, has multiple functions, among which are the regulation of metabolism and the protection of organs. We focus here on bone remodeling, a process by which the structure and chemical composition of bone evolve over time. The biochemical and structural changes of bone tissue are orchestrated by bone cells, able to synthesize bone matrix (osteoblasts), resorb mineralized bone (osteoclasts), and to regulate biochemical signaling pathways according to their mechanical environment (osteocytes). In this context, we are particularly interested in mechanomics, which is the description of the action of mechanics on biological tissues.We first study the mechanics of bone remodeling at the cellular level, where signaling pathways are essential. We therefore introduce a fine mathematical representation of bone remodeling by a system of differential equations describing the interactions between bone cells of osteoclastic and osteoblastic lineages, as well as the regulation of the biochemical environment by osteocytes. This model reproduces the bone loss in the contexts of micro-gravity during space flight and postmenopausal osteoporosis (PMO). The development of a pharmacokinetic-pharmacodynamic model coupled with biochemical dynamics makes it possible to link the dosage of an anabolic treatment of PMO (romosozumab) and the gain of bone mass, which would be beneficial for the design of a treatment specific to the patient.We also propose a macroscopic description of bone remodeling based on a generalized continuum mechanics model. First, this representation is introduced in the context of rotary remodeling of the bone microstructure. Indeed, bone is a material with a micro-architecture, composed of a mineralized collagen matrix and a fluid phase which hosts active bone cells. First, we propose an analytical identification of stable equilibrium states of rotary remodeling. This theory is then used in a 2D finite element study applied to the human femoral head. Finally, we enrich this theoretical framework by linking macroscopic mechanics to mechanobiology: the kinematics of bone remodeling is described through the evolution of macroscopic deformation, microstructural rotation, mineral fraction, porous fraction and cells concentrations. This description encompassing chemistry, biology and mechanics provides a structure for the study of interactions between these three fields in the context of remodeling. The promising results of our preliminary simulations enable an interpretation of remodeling on a small scale that can be compared with clinical data.Finally, we present in this thesis a first clinical application of our multi-scale theory with the study of bone remodeling in patients with idiopathic scoliosis of the adolescent (AIS), pathology of unknown origin characterized by a three-dimensional deviation of the spine. The analysis of the first vertebral body samples from AIS patients taken intraoperatively suggests a dependence of the properties of the material on the abnormal loading conditions due to the pathology. These observations motivate the prospect of a comparison of these results with simulations based on our mechanistic theory.In summary, we present in this thesis several bone remodeling modeling approaches, resulting in the development of a novel unifying theory whose purpose is to better understand and address the mechanisms of bone pathologies, which ultimately aim at the development of patient-specific therapeutic solutions.
Principles Of Bone Regeneration
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Author : Jona J. Sela
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-10
Principles Of Bone Regeneration written by Jona J. Sela and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-10 with Technology & Engineering categories.
Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
The Computational Mechanics Of Bone Tissue
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Author : Jorge Belinha
language : en
Publisher: Springer Nature
Release Date : 2020-02-11
The Computational Mechanics Of Bone Tissue written by Jorge Belinha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-11 with Science categories.
This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.
Bone Remodelling And Its Disorders
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Author : Gregory R Mundy
language : en
Publisher: CRC Press
Release Date : 1999-01-01
Bone Remodelling And Its Disorders written by Gregory R Mundy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Medical categories.
Abnormalities in bone remodelling occur in some of the most common diseases, including osteoporosis, cancer and Paget's disease, and cause considerable suffering This book bridges the gap between cellular and molecular biology, and pathophysiology and treatment This practical and succinct text will be of interest for all those involved in the study, diagnosis and treatment of bone disease
Investigating The Link Between Mechanics And Bone
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Author : Elliott Evan Goff
language : en
Publisher:
Release Date : 2016
Investigating The Link Between Mechanics And Bone written by Elliott Evan Goff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Bones categories.
Bone,the organic material which skeletons are comprised of, allows all species of vertebrates to support themselves against the forces of gravity, engage in locomotion,protect soft internal organs, and a wide variety of other functions depending on the species. The organ is composed of three cell types which work in harmony to continually renew and repair the bone tissue over a lifespan. When the metabolic process of bone remodeling is disturbed, the imbalance leads the organ to create or remove bone incorrectly. Currently it is believed that exercise, technically termed as mechanical loading, also plays a key role in the process of bone remodeling. While the detailed mechanics of exactly how this takes place are still unclear, numerous studies have shown that bone tissue is resorbed when loading is reduced, leading to structural instability and ultimately fracture. The aim of this thesis is to investigate a small portion of the mechano-regulated bone remodeling process at the cellular level and place it into a larger context of the organ.
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism
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Author : Juliet E. Compston
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-22
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism written by Juliet E. Compston and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-22 with Science categories.
EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.