Mechanisms Of Cell Toxicity
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Mechanisms Of Cell Toxicity
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Author : E. Edward Bittar
language : en
Publisher: JAI Press(NY)
Release Date : 1997
Mechanisms Of Cell Toxicity written by E. Edward Bittar and has been published by JAI Press(NY) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Cell-mediated cytotoxicity categories.
Cellular toxicology has entered a new era. No longer are we concerned only with necrotic cell death produced by severe, acute insult (often to multiple intracellular targets) leading to disruption of the cell membrane. New advances in molecular and cellular biology are allowing the dissection of mechanisms of cell death involving more subtle targets within the cell. Toxicology has been very important, not only in understanding the mechanisms, nature, and severity of toxicity and thereby helping in risk assessment, but toxicology has also played a very important role in helping to understand basic biological processes. Historically this has perhaps been most evident in the use of toxic agents to interfere with specific reactions in the body and hence help to dissect out the mechanisms of metabolic processes. For example, the use of chemical inhibitors was very important in understanding the process of oxidative phosphorylation, or the tricarboxylic acid cycle. More recent examples are seen herein where toxicology interfaces with, for example structural biology in the study of the cytoskeletal components and their interactions. Indirectly, an understanding of the mechanisms of endogenous protective systems also improves knowledge of basic cell biology. Toxic insult and manipulation of cell signalling and control mechanisms in cell growth and differentation also highlight how important the discipline of cell toxicity has been and will continue to be a major contributor to our understanding of basic issues in the biological and biomedical sciences. This book offers selected reviews of some of the principal molecular mechanisms of cell toxicity.
Mechanisms Of Cell Mediated Cytotoxicity
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Author : William R. Clark
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Mechanisms Of Cell Mediated Cytotoxicity written by William R. Clark and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, September 14-16, 1981. The Workshop brought together for the first time leading investiga tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity. Formal research presentations were held to a minimum, the emphasis being on open discussion of current knowledge about mechanisms of cytoxicity in each of the systems under consideration. The major objectives of the Workshop were 1) to compare and integrate what is known about the mechanism(s) of cytoxicity in each system; 2) to determine whether, on the basis of information in hand, it seems likely that the mechanisms of cytotoxicity in the various systems are the same or are unique; and 3) to stimulate thinking about new approaches to elucidating the fundamental mechanisms by which certain cells are able to kill other cells.
Molecular And Cellular Mechanisms Of Toxicity
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Author : Lewis L. Smith
language : en
Publisher: CRC Press
Release Date : 2019-06-04
Molecular And Cellular Mechanisms Of Toxicity written by Lewis L. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Mechanisms Of Cell Mediated Cytotoxicity Ii
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Author : Pierre Henkart
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Cell Mediated Cytotoxicity Ii written by Pierre Henkart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book is derived from contributions to the Second International Workshop on Mechanisms in Cell-Mediated Cytotoxicity, held in Annopolis, Maryland, June 10-13, 1984. This workshop was organized by an international committee of immunologists interested in lymphocyte cytotoxic mechanisms (G. Berke, W.R. Clark, P. Golstein, M. Hanna, P. Henkart, R. Herberman, H.R. MacDonald, E. Martz, and C. Nathan), who strove to invite participants who have made major contributions to this field. The Workshop was a follow-up to the highly successful 1981 Workshop, whose proceedings Workshop were published by Plenum as Mechanisms in Cell-Mediated Cytotoxicity, edited by W.R. Clark and P. Golstein. That volume has been much appreciated by researchers and students since it contains accounts of most of the current approaches to understanding cytotoxic lymphocyte mechanisms all in one volume. The present book may be viewed as a follow-up to the first one, and in our opinion fairly summarizes the varying current viewpoints on lymphocyte cytotoxic mechanism. It should be noted that the discussions have been transcribed directly by us, and the participants have not had an opportunity to edit their remarks. We have tried to maintain some of the style of the actual discussion in these transcripts. In some cases technical problems prevented usable transcriptions from being made, and hence not all of the actual discussion at the workshop is reproduced here.
Introduction To In Vitro Cytotoxicology
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Author : Frank A. Barile
language : en
Publisher: CRC Press
Release Date : 2019-06-04
Introduction To In Vitro Cytotoxicology written by Frank A. Barile and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
First Published in 1994, Introduction to In Vitro Cytotoxicology examines in vitro cytotoxicology, which offers new methodologies to toxicity testing. This important new discipline of modern toxicology is gaining increased acceptance as a viable alternative to traditional testing methods. The text discusses the application of in vitro cytotoxicology to toxicity testing and human risk assessment, and it analyzes the advantages and limitations of the tests performed under scientific and regulatory conditions. The book also reviews the optimum utilization of certain tests for specific groups of chemicals relevant to validation programs currently in progress. This book is a useful reference tool for students, researchers, and practitioners interested in academic, industrial, and regulatory toxicology; environmental health; cell biology; pharmacology; dentistry; or human and veterinary medicine.
Mechanisms Of Cell Injury
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Author : B. A. Fowler
language : en
Publisher: Wiley
Release Date : 1987-07-21
Mechanisms Of Cell Injury written by B. A. Fowler and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-07-21 with Science categories.
International experts evaluate mechanisms of chemically induced cell injury and cell death and their implications for human health. Among the wide variety of topics explored are the role of metabolism in mediating toxicity, molecular mechanisms of cell injury/cell death, approaches for estimating human exposure to toxic chemicals, and the known roles of toxic chemicals in human target organ toxicity. The discussions are intended to provide an overview of the most recent work in this area, to define and discuss research priorities in this field, and to indicate directions for future research.
Mechanisms Of Cell Death And Opportunities For Therapeutic Development
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Author : Diaqing Liao
language : en
Publisher: Academic Press
Release Date : 2021-10-26
Mechanisms Of Cell Death And Opportunities For Therapeutic Development written by Diaqing Liao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-26 with Science categories.
Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research
Mechanisms Of Cell Mediated Cytotoxicity Ii
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Author : Pierre Henkart
language : en
Publisher: Springer
Release Date : 2012-10-20
Mechanisms Of Cell Mediated Cytotoxicity Ii written by Pierre Henkart and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-20 with Medical categories.
This book is derived from contributions to the Second International Workshop on Mechanisms in Cell-Mediated Cytotoxicity, held in Annopolis, Maryland, June 10-13, 1984. This workshop was organized by an international committee of immunologists interested in lymphocyte cytotoxic mechanisms (G. Berke, W.R. Clark, P. Golstein, M. Hanna, P. Henkart, R. Herberman, H.R. MacDonald, E. Martz, and C. Nathan), who strove to invite participants who have made major contributions to this field. The Workshop was a follow-up to the highly successful 1981 Workshop, whose proceedings Workshop were published by Plenum as Mechanisms in Cell-Mediated Cytotoxicity, edited by W.R. Clark and P. Golstein. That volume has been much appreciated by researchers and students since it contains accounts of most of the current approaches to understanding cytotoxic lymphocyte mechanisms all in one volume. The present book may be viewed as a follow-up to the first one, and in our opinion fairly summarizes the varying current viewpoints on lymphocyte cytotoxic mechanism. It should be noted that the discussions have been transcribed directly by us, and the participants have not had an opportunity to edit their remarks. We have tried to maintain some of the style of the actual discussion in these transcripts. In some cases technical problems prevented usable transcriptions from being made, and hence not all of the actual discussion at the workshop is reproduced here.
Molecular Mechanisms Of Metal Toxicity And Carcinogenesis
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Author : Xianglin Shi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Mechanisms Of Metal Toxicity And Carcinogenesis written by Xianglin Shi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.
Mechanisms Of Cell Death
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Author : International Cell Death Society. Conference
language : en
Publisher:
Release Date : 2000
Mechanisms Of Cell Death written by International Cell Death Society. Conference and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Apoptosis categories.