Mechanisms Of Cerebral Hypoxia And Stroke
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Mechanisms Of Cerebral Hypoxia And Stroke
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Author : G. Somjen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Mechanisms Of Cerebral Hypoxia And Stroke written by G. Somjen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
The articles and short communications in this volume are based on papers pre sented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August of 1987. Besides participants at the meeting, three scientists who were invited but could not attend have also contributed chapters to this volume. A synopsis of the general discussion at the conference and a review chapter conclude this volume. To the readers of this book it will not be news that stroke is a worldwide problem. Efforts to cope with this often devastating condition are worldwide also, as attested by the international membership of the conference. It has been said of oxygen deficiency that it not only stops the machine, it also wrecks the machinery. The paramount question in stroke research is this: why can't the brain be restarted after a hypoxic episode in much the same manner as a motor car can when its gas tank is refilled after it stalled because it ran out of fuel? Participants at the Symposium had been requested in advance of the meeting to especially consider a series of specific questions in relation to this general problem. Among these specific questions were: the mechanism of synaptic blockade in hypoxic brain tissue; the transition from reversible to irreversible arrest of function; the nature of postischemic (delayed) cell death; the possible basic differences in the consequences of hypoxia and ischemia; and actual and potential approaches to the prevention and treatment of cell damage in hypoxia and stroke.
Mechanisms Of Cerebral Hypoxia And Stroke
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Author : G. Somjen
language : en
Publisher:
Release Date : 1988-11-01
Mechanisms Of Cerebral Hypoxia And Stroke written by G. Somjen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-11-01 with categories.
Brain Hypoxia And Ischemia
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Author : Gabriel G. Haddad
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-01-06
Brain Hypoxia And Ischemia written by Gabriel G. Haddad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-06 with Medical categories.
Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.
Cerebral Blood Flow
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Author : Michael Pinsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cerebral Blood Flow written by Michael Pinsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cerebral Blood Flow: Quantifying Consciousness Although the heart may be the source of energy needed to generate blood flow,and other organs absolutely essential for normal living,the brain is the reason we are alive. The collected book chapters are aimed at addressing this most fundamental organ and its blood flow. These papers reflect detailed descriptions of similar topics presented over a two-day period as part of the 5th International Symposium on Applied Physiology of the Peripheral Circulation held in Pittsburgh, Pennsylvania, in June 2000. The symposium and this volume were organized into four distinct groupings that follow in a logical fashion. The initial papers focus on the basic unique physiology and pathophysiology of the cerebral circulation, including a historical reviewof the means to measure cerebral blood flow and its implications of the past 30 years. Dr. Walter D. Obrist was one of the original investigators to use radiolabeled markers to assess cerebral blood flow. His equations and initial studies form an impressive introduction to where we are now. As with much of the body's special organs, the brain too has many circulatory features unique to itself.These include the unique blood-brain barrier function ofthe endothelium, local neural regulation control, and intracranial pressure effects. These special issues,plus genetic factors that may predispose individuals to developing cere bral aneurysm, make up the initial section of the monograph.
New Trends In Brain Hypoxia Ischemia Research
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Author : Eetu Hämäläinen
language : en
Publisher: Nova Publishers
Release Date : 2008
New Trends In Brain Hypoxia Ischemia Research written by Eetu Hämäläinen and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
This book presents recent and significant research from around the world dedicated to brain hypoxia-ischemia which is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.
Brain Hypoxia Ischemia Research Progress
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Author : Océane M. Roux
language : en
Publisher: Nova Publishers
Release Date : 2008
Brain Hypoxia Ischemia Research Progress written by Océane M. Roux and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Cerebral anoxia categories.
Brain hypoxia-ischemia is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain oedema; coma; and other conditions. This book presents the latest research in this field from around the world.
The Brain Without Oxygen
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Author : P.L. Lutz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
The Brain Without Oxygen written by P.L. Lutz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Medical categories.
It is well known and researched, that deprivation of oxygen to the brain can quickly result in irreversible damage and death. What is less well known, is that some vertebrate species are exceptionally tolerant of brain hypoxia. The Brain Without Oxygen: Causes of failure - Physiological and molecular mechanisms for survival, Third edition, discusses the mechanisms of brain hypoxia tolerance in these exceptional vertebrates, which include diving marine mammals, high altitude dwellers and the hibernating mammal. Special attention is given to the extraordinary adaptations that allow a few turtle and fish species to tolerate months of brain anoxia. This third, fully updated edition addresses the potential of these animal models as targets for human clinical intervention. Perhaps the most interesting of these, are those involved in the suppression of metabolic activities to new set points well below their normoxic minima or maintenance levels. This volume will be valuable reading for researchers in physiology, medicine and general biological sciences, and of great importance to pharmaceutical companies researching novel models for stroke and brain ischemia.
Brain Hypoxia
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Author : H. Penzholz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Brain Hypoxia written by H. Penzholz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains the papers presented at the 26th Annual Meeting of the Deutsche Gesellschaft fUr Neurochirurgie, held in Heidelberg, Western Germany, on May 1-3,1975. Since at recent meetings of the German Neurosurgical Society central pathophysiological problems such as "central dysregulation" and "brain edema" had been discussed extensively, it seemed appropriate to choose another major area of cerebral patho physiology for the meeting in Heidelberg. CEREBRAL HYPOXIA is, as LANGFITT once emphasized, "the final common denominator" of various cerebral lesions with which the neurosurgeon is confronted every day. Raised intracranial pressure, respiratory disorders and disturbances in systemic arterial blood pressure, etc. may lead, if not treated, to a focal or global lack of oxygen in the brain tissue. Anoxia finally results in cell death and thus in irreversible cerebral damage or even death. Main interest has therefore been focussed on disturbances in cerebral perfusion pressure ("ischemic hypoxia") and in arterial oxygenation ("hypoxic hypoxia"). The importance of cerebral autoregulatory mechanisms protecting the brain against tissue hypoxia, of patho morphological alterations of the cerebral vessels (e. g. the "no-reflow-phenomenon") in the course of severe hypoxia, and of changes in brain metabolism have been discussed on a large scale. The organizing committee was particularly happy to have obtained internationally well-known scientists who presented their work in the field of cerebral hypoxia.
Stroke
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Author : Jens Minnerup
language : en
Publisher: Biota Publishing
Release Date : 2013-08-01
Stroke written by Jens Minnerup and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-01 with Science categories.
Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.
Ischemic Stroke
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Author : Chung Y. Hsu
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1998
Ischemic Stroke written by Chung Y. Hsu and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Stroke is the third leading cause of death in industrialized countries and the number one cause of disability in adults. Ischemic strokes constitute approximately 80% of all strokes, and until recently, no effective therapies had been available. The successful tissue plasminogen activator (tPA) trials open a new era of stroke management with a proven therapeutic now available to patients if they arrive at the hospital within hours of the onset of symptoms. Recent advances in our understanding of the molecular mechanisms of ischemic brain injury and vascular pathology have opened up new avenues for the development of novel therapeutic strategies. The premise that substantial reduction of brain damage after ischemic stroke by therapeutic intervention has now been confirmed in animal stroke models, sets a realistic goal for future treatment of stroke patients. This book covers topics ranging from fundamental molecular mechanisms of ischemic brain injury to the most current views on the clinical stroke trials and academic and industrial efforts to develop new drugs. The authors are leading authorities in their own fields in basic and clinical stroke research. As a timely and comprehensive volume, it will be of immense value to basic and clinical investigators, neurologists and neurosurgeons who manage stroke patients, neuroscientists interested in various aspects of brain injury, and researchers in the pharmaceutical industry who are engaged in new drug development.