Mechanisms Of Progression To Hormone Independent Growth Of Breast And Prostatic Cancer
DOWNLOAD
Download Mechanisms Of Progression To Hormone Independent Growth Of Breast And Prostatic Cancer PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Mechanisms Of Progression To Hormone Independent Growth Of Breast And Prostatic Cancer book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Mechanisms Of Progression To Hormone Independent Growth Of Breast And Prostatic Cancer
DOWNLOAD
Author : P. M. J. J. Berns
language : en
Publisher: Parthenon Publishing
Release Date : 1991
Mechanisms Of Progression To Hormone Independent Growth Of Breast And Prostatic Cancer written by P. M. J. J. Berns and has been published by Parthenon Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
As a contribution to the increasing interest in endocrine therapy to inhibit cancer growth, 13 papers from a workshop in Rotterdam, April 1990, explore possible factors associated with a tumor's progression from hormone-dependent to hormone-independent, focusing on breast and prostatic cancer. Annotation c. by Book News, Inc., Portland, Or.
Advances In Rapid Sex Steroid Action
DOWNLOAD
Author : Gabriella Castoria
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-15
Advances In Rapid Sex Steroid Action written by Gabriella Castoria and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-15 with Medical categories.
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
Investigation Of The Akt Pkb Kinase In The Development Of Hormone Independent Prostate Cancer
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2005
Investigation Of The Akt Pkb Kinase In The Development Of Hormone Independent Prostate Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Our laboratory has been interested in the role of Akt in the development of hormoneindependent cancers. Using a breast cancer cell model, we previously demonstrated that tumors with a constitutively active Akt are resistant to anti-hormone therapy. In this study we have expanded upon our preliminary observations in the breast model into in vitro prostate cancer models to determine the molecular and biological mechanisms underlying these findings. In our first year of this study, we found that treatment with an Akt inhibitor prevented the progression of LNCaP cells to a state of androgen-independence. The results of these studies could have a significant impact on clinical approaches for the treatment of recurrent prostate cancer. Currently, progression of prostate cancer to androgen independence remains the primary obstacle to improved survival with this disease. In order to improve overall survival, novel treatment strategies that are based upon specific molecular mechanisms that prolong the androgen-dependent state and that are useful for androgen-independent disease need to be identified. The results of our studies suggest that targeting the Akt pathway may provide such a strategy, resulting in increased survival among patients with recurrent disease.
Influence Of The Nuclear Hormone Receptor Axis In The Progression And Treatment Of Hormone Dependent Cancers
DOWNLOAD
Author : Janet K. Hess-Wilson
language : en
Publisher:
Release Date : 2007
Influence Of The Nuclear Hormone Receptor Axis In The Progression And Treatment Of Hormone Dependent Cancers written by Janet K. Hess-Wilson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Due to its pivotal role in prostatic growth and survival, the androgen receptor (AR) is the primary target of disseminated prostate cancer (CaP), as achieved via androgen deprivation therapy (ADT). Unfortunately, ADT is circumvented by restoration of AR activity, resulting in ADT resistant tumors for which there is no alternate treatment option. Through multiple mechanisms, reactivation of the AR specifically underlies the progression to therapy resistant tumors. The environmentally prevalent endocrine disrupting compound (EDC), bisphenol A (BPA) is able to activate specific somatically mutated ARs commonly found in CaP, resulting in androgen-independent proliferation of CaP cells. To directly assess the effect of BPA on ADT, we used an in vivo xenograft model of CaP that expresses a BPA-sensitive mutant AR, and mimics standard human cytotoxic response to ADT, followed by subsequent tumor re-growth. When tumor-bearing animals were exposed to environmentally relevant levels of BPA during ADT, the tumors failed therapy more rapidly (compared to placebo controls), with AR reactivation and concomitant increased tumor cell proliferation. These data suggest that environmentally relevant exposure to EDCs may reduce the efficacy of mainline ADT for CaP. We next determined that the environmentally persistent pesticide, DDE, was able to activate select AR mutants, and in in vitro models of CaP, DDE induces cellular proliferation in the absence of androgen, demonstrating that this observed response was not unique to BPA. Strikingly, the mechanism of DDE impact on CaP cells was distinct from BPA, in that at low doses this agent also activated the MAPK pathway, and requires this activation for mitogenesis. Given the context specific impact of AR activation by EDCs, and the deleterious effect of exposure to BPA on ADT in vivo, we next addressed the impact of AR action on taxane-based therapy. These cytotoxic agents have recently been shown to improve survival outcome for patients with advanced CaP, and are potentially new second line therapies, however the impact of AR action on this cytotoxic modality had yet to be assessed. Contrary to the stigma of AR as a survival factor, we found that AR activation by both endogenous and exogenous agonists (i.e. DHT and BPA), synergized with taxanes to decrease cell survival, through p53-mediated, caspase dependent apoptosis. This synergistic action was attributed directly to the AR-dependent mitogenic capacity of these agents. Importantly, these data further support the conclusion that the environmental impact on AR action and CaP therapeutic outcome is context specific. We further evaluated the complexity of EDC affects by assessing the impact of these agents under clinically relevant conditions in another hormone-dependent tissue, breast cancer. BPA and the phytoestrogen, coumestrol (COU), were able to activate the estrogen receptor (ERalpha), but this activation was restricted to estrogen-depleted conditions, and could be blocked by the standard ER antagonist, tamoxifen. Additionally, BPA and COU have disparate affects in multiple analyses including mutant ERalpha activation, and specific coactivator deregulation. In conclusion, the environmental impact on nuclear receptor signaling and hormone dependent cancer progression and treatment is highly molecular context specific. Therefore, the impact of EDCs on hormone dependent cancer treatment needs to be identified under specific and well defined, clinically relevant, molecular contexts.
Prostate Cancer
DOWNLOAD
Author : Leland W. K. Chung
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-10
Prostate Cancer written by Leland W. K. Chung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-10 with Medical categories.
Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.
Do Soy Isoflavones Provide Protection Against Prostate Cancer Via A Classical Estrogen Receptor Alpa Er Independent Mechanism
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1999
Do Soy Isoflavones Provide Protection Against Prostate Cancer Via A Classical Estrogen Receptor Alpa Er Independent Mechanism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Male populations, which consume soy foods as a major component of their diet, have reduced incidence of prostate cancer. The anti-sex hormone activity in soy has been proposed, but not proven, to provide protection from prostate cancer. Among the soy isoflavones, genistein and daidzein have been found to be the most effective in suppression of breast cancer growth and in vitro prostate cancer cell proliferation. We are testing the hypothesis that soy isofiavones, specifically genistein and daidzein, will provide protection from development and progression of prostate cancer in mice lacking functional estrogen receptor-alpha protein and containing the PBTag transgene (TRAMP mice). We are testing if the phytoestrogens are working through ERalpha and/or ERbeta and other non-ERalpha estrogen response proteins. The latency of tumor development, tumor size and number, biochemical markers, and histological features will be determined on selected tumors to characterize the progression from normal prostate to neoplastic and metastatic prostate cancer. Through these innovative experiments, we can establish which soy isoflavones are protective against prostate cancer, and we can establish which estrogen receptor pathways are involved.
Molecular Biology Of Prostate Cancer
DOWNLOAD
Author : Manfred Wirth
language : en
Publisher: Walter de Gruyter
Release Date : 2013-05-22
Molecular Biology Of Prostate Cancer written by Manfred Wirth and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.
Signal Transduction In Cancer
DOWNLOAD
Author : David A. Frank
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-31
Signal Transduction In Cancer written by David A. Frank and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-31 with Medical categories.
One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
The Basic Science Of Oncology
DOWNLOAD
Author : Ian Tannock
language : en
Publisher: McGraw Hill Professional
Release Date : 2005
The Basic Science Of Oncology written by Ian Tannock and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.
Physical Activity And Cancer
DOWNLOAD
Author : Kerry S. Courneya
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-26
Physical Activity And Cancer written by Kerry S. Courneya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-26 with Medical categories.
This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.